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Aim To investigate the effect of Li-Zhong-Tang (LZT) in the treatment of gastric ulcer (GU) with pattern of spleen-stomach vacuity cold in rats based on Raf/MEK/ERK signaling pathway and the underlying molecular mechanism. Methods SD rats were randomly divided into normal group, GU model group, esomeprazole (ESO) group, LZT low dose and high dose groups. The morphological changes of gastric mucosa were observed by naked eyes and HE staining. The activities of gastric acid and pepsin were measured. The contents of prostaglandin E
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ObjectiveTo assess the effect of Fuzi-Lizhongdecoction for the diarrhea irritable bowel syndrome (IBS-D) with the Chinese pattern of spleen kidney yang deficiency.MethodsA total of 98 patients diagnosed IBS-D with spleen kidney yang deficiency Chinese patternwere included from April,2014 toMarch, 2015 in our hospital,and were randomly divided into the control group and Traditional Chinese Medicine (TCM) group at ratio of 1:1, 9 paitents in each group, two groups were administrated with the convetional treatment such as correct water, electrolyte disorders. Besides, the control group was added withsulfasalazine treatment, and TCM group withFuzi-Lizhongdecoction. Outcomes includedchanges of symptoms scores, questionnaire scores, TCM syndrome scores, endoscopic scoresand adverse events.Results After treatment, the TCM group showed significantly lower scores of symptoms (1.80 ± 0.19vs. 490 ± 2.24,t=9.653), questionnaire (14.01 ± 7.11vs.31.44 ± 12.91,t=8.278), TCM syndrome (2.33 ± 0.10 vs.4.86 ± 0.93,t=18.934), endoscopic assessment (0.89 ± 0.03 vs.1.60 ± 1.14, t=4.358) than those of the control group (P<0.01). The TCM group showed significantly higher effective rate (93.88%vs.75.51%) than the control groupa (χ2=6.376,P=0.012). The adverse events of TCM group and control group were 0% (0/49) and 12.24% (6/49), and the difference was statistically significant (χ2=6.391,P=0.012).Conclusion Fuzi-Lizhong decoction is safe and effective therapy for IBS-D with Chinese pattern of Yang deficiency of spleen and kidney.
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Objective To compare the clinical efficacy of different doses of ultrafine extracted granule preparation (EGP) and traditional herbal decoction (THD) of Li Zhong Tang in treatment of epigastric pain. Methods Sixty cases of epigastric pain patients in accordance with the diagnostic criteria of deficiency and cold pattern of spleen and stomach in TCM were randomly divided into THD group, 1/3 dose group and 1/5 dose group, and were given THD, 1/3 dose of ultrafine EGP and 1/5 dose of ultrafine EGP, respectively. The clinical efficacy of the three groups after one course of medication was comparatively analyzed. Results There were no significant differences in age, course of disease, symptom score before treatment, epigastric pain efficacy and syndrome curative effect among the three groups, the differences had no statistical significance (P>0.05). The severity, frequency and duration of epigastric pain were all reduced in the three groups, with significant differences between before and after treatment (P<0.05). Conclusion There are no significant differences in the clinical efficacy on epigastric pain among THD, 1/3 dose of ultrafine EGP and 1/5 dose of ultrafine EGP. In addition, the effect of 1/3 dose group is very close to the THD group.