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Avaliar o perfil lipídico no pré e pós-operatório de pacientes submetidos ao bypass gástrico em Y de Roux. Métodos: Trata-se de um estudo retrospectivo com pacientes que se submeteram ao bypass gástrico em Y de Roux no Hospital das Clínicas da Universidade Federal de Pernambuco. Foram coletados dados de peso, índice de massa corporal (IMC), circunferência da cintura (CC), razão cintura-quadril (RCQ), colesterol total (CT), lipoproteína de alta densidade (HDL-c), lipoproteína de baixa densidade (LDL-c) e triacilgliceróis (TG) antes e após 3 meses de cirurgia. A presença de dislipidemia foi definida como alteração em pelo menos um dos parâmetros lipídicos avaliados. Resultados: Foram estudados 30 pacientes, sendo 83,3% do sexo feminino. A média de idade foi de 42,4 ± 9,6 anos. A dislipidemia, presente em 83,3% dos pacientes, diminui para 63,3% após 3 meses. No pré-operatório 6,7% apresentaram hipercolesterolemia isolada, 13,3% hipertrigliceridemia isolada e 63,3% HDL-c baixo ou em associação com aumento de TG ou LDL-c. Após 3 meses, essas prevalências foram de nenhum caso, 3,3% e 60%, respectivamente. O risco cardiovascular, mensurado através da razão TG/HDL-c, foi encontrado em 23,3% da população e em 10% após 3 meses. Houve redução significativa nas médias de peso, IMC, CC, CT, LDL-c, TG e TG/HDL-c (p<0,05). Conclusão: Em apenas três meses de pós-operatório, a cirurgia bariátrica mostrou-se efetiva em melhorar o perfil lipídico e, consequentemente, alguns fatores de risco cardiovascular.
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Humans , Male , Female , Young Adult , Middle Aged , Lipids , Blood , Bariatric Surgery , Obesity, MorbidABSTRACT
JUSTIFICATIVA E OBJETIVOS: Identificar o perfil lipídico dos pacientes renais crônicos e analisar a prevalência das alterações lipídicas nesses pacientes. MÉTODOS: Realizado um estudo retrospectivo em 136 pacientes portadores de doença renal crônica (DRC) não dialítica atendidos em um único ambulatório. Foram coletados os seguintes dados: sexo, idade, comorbidades, medicações em uso, exame físico e exames laboratoriais. Calculou-se a prevalência das principais dislipidemias e as variáveis foram analisadas por meio das estatísticas descritivas: média aritmética e mediana. Foram utilizados os testes t de Student, Mann-Whitney, qui-quadrado e Exato de Fisher. As variáveis foram comparadas entre os grupos com e sem dislipidemia. RESULTADOS: A prevalência de dislipidemias foi de 75,7%, sendo a média dos valores de colesterol total (CT) de 179,6±41,0mg/dl, HDL-colesterol de 46,1±12,6mg/dl,LDL-colesterol de 101,7±34,5mg/dl e de triglicerídeos de 160,0±87,2mg/dl. O grupo com dislipidemia apresentou níveis superiores de triglicerídeos e inferiores de HDL-colesterol. CONCLUSÕES: Observamos elevada prevalência de dislipidemia neste estudo.
BACKGROUND AND OBJECTIVES: Identify the lipid profile of chronic renal patients and the prevalence of lipid disorders in these patients. METHODS: A retrospective study was performed in 136 patients with chronic kidney diseases (CKD) not dialytic, treated in a unique clinic. The following data were collected: gender, age, comorbidities, medications in use, physical examination and laboratory tests. It has been estimated the prevalence of dyslipidemias and main variables were analyzed through descriptive statistics: arithmetic mean and median. The Student's t-tests, Mann-Whitney, chi-squareand Fisher exact were used. Variables were compared between groups with and without dyslipidemia. RESULTS: The prevalence of dyslipidemias was 75.7%, with an average of the total cholesterol of 179.6±41.0mg/dl, HDL-cholesterol of 46.1±12.6mg/dl, LDL cholesterol of 101.7±34.5mg/dl and triglyceride levels of 160.0±87.2mg/dl. The group with dyslipidemia showed increased levels of triglycerides and lower HDL cholesterol. CONCLUSIONS: We observed a high prevalence of dyslipidemia in this study.
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Humans , Male , Female , Middle Aged , Cardiovascular Diseases , Dyslipidemias , Hypolipidemic Agents/therapeutic use , Lipids/blood , Renal Insufficiency, ChronicABSTRACT
Background Bietti crystalline dystrophy (BCD) is a congenital and autosomal recessive hereditary eye disease characterized by multiple glistening intraretinal crystals scattered over the fundus.Studies determined abnormality of fatty acid metabolism probably is associated with BCD.However,the study on the alteration of blood lipid level in BCD patients is rare.Objective This trail was to study the change of serum lipids in BCD patients.Methods A total of 50 patients with bilateral BCD and 50 matched healthy volunteers were included from November 2011 to March 2013 in Beijing Tongren Eye Center with the approval of Ethic Committee of Beijing Tongren Hospital.Written informed consent was obtained from each subject before any medial examination.Peripheral blood of 3 ml was collected from the subjects.The serum concentrations of triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured and analyzed.The examination outcome was identified based on the criteria of China Adult Dyslipidemia Prevention Guideline (Version 2007).Results Abnormality of serum lipid content was detected in 58.00％ patients (29/50),and hypertriglyceridemia and hypercholesteremia were in 34.48％ (10/29),respectively,and mixed hyperlipidaemia was in 27.59 ％ (8/29).The serum levels of TG,TC and LDL-C were (1.63± 1.19) mmol/L,(5.10±1.05) mmol/L and (3.27±0.97) mmol/L in the BCD group,which were significantly higher than (0.93± 0.33) mmol/L,(4.33 ±0.56) mmol/L,(2.63 ±0.51) mmol/L of the normal group (t =4.036,4.496,4.095,all at P=0.000).Conclusions The serum lipid levels elevate in BCD patients,which might be related to the occurrence of BCD.
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Objective To explore the lipid metabolism in patients with hypertension and obstructive sleep apnea-hypopnea syndrome.Methods A total of 896 patients (655 cases of male; 241 cases of female) was recruited who were hospitalized in our department,and were classified into four groups based on the finding of polysomnography (PSG):hypertensive without obstructive sleep apnea-hypopnea syndrome (OSAS) (n =243),hypertensive with mild OSAS (n =245),hypertensive with moderate OSAS (n =195),and hypertensive with severe OSAS (n =213).Multiple indices including apnea-hypopnea index (AHI),lowest arterial oxygen saturation(lowest SaO2),body mass index (BMI),blood pressure,total cholesterol (TC),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDLC),triglycerides (TG),fasting blood glucose(FBG),uric acid (UA),and high-sensitivity C-reactive protein(hs-CRP) were assessed,and the relevant risk factors of lipid metabolism were analyzed.Results (1)Male patients had more opportunities to suffer OSAS than female (P ＜0.01).Compared with the group without hypertensive,patients in severe OSAS group had higher levels of AGE (48.09 ± 9.48,BMI (29.46 ±3.83),AHI[45.90(37.55,63.65)],MSpO2 (89.08 ±4.93),LSpO2 (67.36 ± 12.60),TC (4.68 ±1.00),TG[2.03(1.54,2.88)],UA (371.85 ±99.29),and hs-CRP[1.43(0.82,3.056)] (P ＜0.05),and had lower levels of HDL-C (1.09 ± 0.28).(2) Two and more than two lipids abnormal metabolic indices increased prevalence with the increase of the severity of OSAS.(3)The prevalence of high TG,high TC in AHI ≥ 15/h was significantly higher than AHI ＜ 15 group.(4) After adjustment for BMI,gender,age and other common risk factors,it confirmed that AHI was still related to lipid metabolism.AHI was an independent risk factor for abnormal lipid metabolism.Conclusions AHI was an independent risk factor for abnormal lipid metabolism.With increasing severity of OSAS,the levels TC,TG,and the category of abnormal lipid metabolism were also increased.
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Objective To study the prevalence of metabolic syndrome (MS) within the Uyghur people with abnormal glucose metabolism in Xinjiang province according to three different diagnostic criteria and effects of accumulation of MS components on blood lipid profile.Methods Components of MS and blood lipid profile were observed with 666 Uyghur people with abnormal glucose metabolism after cluster randomized sampling method for selecting in Xinjiang province,and analyzed with the recommended diagnostic criteria by the National Cholesterol Education Program-Adult treatment Panel Ⅲ(NCEP-ATP Ⅲ,2001),the Chinese Diabetes Society under Chinese Medical Association (CDS,2004) and the International Diabetes Federation (IDF,2005).Results Prevalence of MS was 21.92％ (14.67％),23.72％ (15.88％),57.51％ (38.48％) with the criteria by NCEP-ATPⅢ,CDS,and IDF,respectively.IDF was the best among three criteria.The most combination was the abnormal glucose metabolism,dyslipidemia and obesity.In the ATPⅢ (2001),with the increase of number of components of metabolic syndrome,highdensity lipoprotein cholesterol (HDL-C) drop,low density lipoprotein cholesterol (LDL-C) increased; there was not significant difference in the CDS.Conclusions The incidence of MS was high in the Uyghur people with abnormal glucose metabolism in Xinjiang province.Most of them complicated with dyslipidemia.One of common components of MS included the elevated triglycerides,decreased HDL-C,and increased size of LDL-C particles,which could easily cause cardiovascular disease.
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Objective To investigate relationship between serum uric acid, blood lipids and blood pressure in obesity children.Methods 71 obese volunteers were selected as obesity group and 30 normal volunteers who matched obese volunteers in age and sex as control group from 13 702 children in Xiangtan city by sampling survey. Their body mass index(BMI), systolic and diastolic blood pressure(SBP,DBP),serum uric acid(UA), high-sensitive C-reactive protein(hs-CRP) and blood lipids were checked respectively. Then ,the difference between the two groups was compared and the relationship of all indexes was analyzed, then the difference between the two groups was compared and the relationship of all indexes was analyzed.Results The values of serum UA,hs-CRP, triglyceride(TG),low density lipoprotein cholesterol(LDL-C) and apolipoprotein B(apoB) in obesity group were significantly higher than those in control group (P
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Objective To discuss the application of serum hs-CRP and lipids detection and the correlations between them in type 2 diabetes mellitus.Methods The levels of serum hs-CRP,TC,TG, HDL-C,LDL-C,ApoA1,ApoB were all measured in 49 type 2 diabetic patients and 53 normal cases.Results The type 2 diabetic group had significantly higher hs-CRP, TC,TG, LDL-C, ApoB and lower HDL-C than the control group. The concentration of serum hs-CRP correlated positively with TG,ApoB and negatively with HDL-C.Conclusion Serum hs-CRP level is associated with serum lipid level and inflammatory response might play an important role in the pathogenesis of type 2 diabetes mellitus. In type 2 diabetic mellitus there is an increased risk of development of cardiovascular diseases.
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Aim To study the prevalence of blood- lipid level and abnormal lipdemia in Xinjiang pasturing area minority,and select high risk population.Methods A current investigation of 1 084 Mongol and Kazakan people with the methods of random sample, meanwhile, according to criterion to collect vein blood to measure blood TC,TG,LDL- C , to calculate HDL- C with numeration.Statistical analysis with SPSS software package. To take corresponding statistical methods according to characteristics of the documents.Results (1) Hyper LDL- C,low HDL- C are the key types in this pasturing area, the former prevalence was 51.0% and 32.1% among the male and female; and the later was 50.2% and 29.8% (χ 2=39.50,45.60,P< 0.01), both near average standard in our country.(2)Abnormal lipdemia was related to age and sex,that was more higher in the male group than that in female group, and increased with the age, but the female group was more higher than male group over 60 years old.(3)The general standard tendency of HDL- C in female group was higher than that in male group, but with no statistics difference.(4)Compared with other areas,TC,LDL- C standard on the higher level,but TG,HDL- C on the lower.(5)Compared with the blood- lipid level of the same minority ten years before,TC,TG,LDL- C showed an increasing trend,however,HDL- C which had protection to human body showed a decreasing trend.Conclusion The Mongol and Kazakan people in Xinjiang pasturing areas are the hyper prevalence of the abnormal blood- lipid level.The etiology may be connected with the heredity susceptibility, on the other hand,the dietetic structure and habits can not be ignored.
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Objective To observe the effects of aminoguanidine and Vitamin C on lipid of streptozotocin-induced didbetic rats.Methods Diabetic nephropathy rats were induced by intraperitoneal injection of streptozotocin.Fifty Sprague-Dawley(SD) rats were randomly divided into normal control group,model group,Vitamin C group,aminoguanidine group and Vitamin C associated with aminoguanidine group.All the rats were treated for 16 weeks.During and after the treatment,the general state of the rats was observed and the levels of blood sugar,triglyceride,total cholesterol,low density lipoprotein,high density lipoprotein,glycosylated hemoglobin,and glycated low density lipoprotein in different groups were detected.Results The rats in the four groups suffered diabetes mellitus and renal function lesion.Aminoguanidine and Vitamin C could improve the general state of the rats,but had no effect on the blood sugar.Vitamin C could decrease the levels of triglyceride,serum cholesterol,low density lipoprotein,glycosylated hemoglobin,and glycated low density lipoprotein,and increase the level of high density lipoprotein.There was a synergistic effect with the combination of the two drugs. Conclusion Aminoguanidine and Vitamin C have no effect in the decrease of blood sugar level but have a certain effect on regulating blood lipid.There is a synergistic effect with the combination of the two drugs.