ABSTRACT
Objective To study the clinical effect of Liushen mixture combined with hyperoxia solution to treat the pressure sores of advanced cancer patients. Methods 43 cases of advanced cancer patients with pressure sores were randomly divided into the experimental group (21 patients)and the control group (22 patients). All patients received conventional care after debridement, the experimental group was treated by 30 to 60 Liushen pills grinded into powder reconciled with 3～8 ml 2% lidocaine to cover the affected area as external fomentation by sterile gauze which was soaked by hyperoxia solution, fixed with cling film,regular replacement The control group was coated with silver sulfadiazine sterile gauze and regular replacement. The cure rate, efficiency rate, and healing time of pressure sores of the two groups were observed respectively. Results In the experimental group the cure rate and efficiency rate were respectively 76.19% and 90.48%, and the cure rate and efficiency rate of the control group were 45.45% and 63.64%, the difference was statistically significant. In the experimental group the phase Ⅲ pressure sores' healing time was ( 13.60± 4.92)days, the healing time of the control group was(20.76 ± 5.51 )days, the difference was statistically significant. Conclusions Liushen pills and lidocaine mixture combined with hyperoxia solution to treat the pressure sores of advanced cancer patients have significant effect and are worthy of clinical application.
ABSTRACT
AIM: To develop a GC/MS method for analyzing volatile compounds in Liushen Pill and Japanese(Jiuxin) Pill. METHODS: The gas chromatograph was fitted a fused-silica capillary column with a VF-5 ms stationary phase and dimensions:30 m?0.25 mm i.d.,0.25 ?m film thickness.The carrier gas was helium at a flow-rate of 1 mL/min.Injector temperature was at 280 ℃ and operated in the splitless mode.The temperature of the GC-MS transfer line was at 250 ℃.Full scan electron impact ionization data were acquired under the following condition:solvent delay 6 min.70 eV electron impact energy,scan time 0.87 sencond/scan,emission current 80 mA,manifold and trap temperatures 45 ℃ and 170 ℃. RESULTS: The quantitative method was accepted with good specificity,wide linear range and low LOD.At the same time,the content of isoborneol was determined by a semi-quantitative approach. CONCLUSION: The research is propitious to offer an effective and reliable pattern for analyzing volatile compounds in complex composite formulae.
ABSTRACT
AIM: To investigate the concentration of bufadienolides in Liushen Pill from two enterprises. METHODS: Four kinds of bufadienolides were simultaneously determined by using HPLC with DAD detector. RESULTS: Recoveries obtained from the four kinds of bufadienolides were higher than 96%,the linearity was in the range of 1 ?g/mL-100 ?g/mL.The concentration of bufadienolides in Liushen Pill was significantly higher than that in other related TCM compatibilities. CONCLUSION: The well-distributed compatibility in Liushen Pill has an influence on the solubilization of bufadienolides,may be in relation to eahancing to release.