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1.
The Korean Journal of Parasitology ; : 295-302, 2006.
Article in English | WPRIM | ID: wpr-220309

ABSTRACT

Liver function tests were performed in 61 vivax, 54 malariae and 15 ovale malaria patients who were admitted to Bangkok Hospital for Tropical Diseases between 2001 and 2004. The objective of the study was to evaluate changes in hepatic biochemical indices before and after treatment with artemisinin derivatives. On admission and prior to treatment, hepatic dysfunction was found among the 3 groups. Serum liver function tests and physical examinations were performed weekly during the 28-day follow-up period. Initially elevated serum bilirubin and diminished albumin returned to normal within 2 weeks of treatment. Serum alkaline phosphatase and aminotransferases returned to within normal limits within 3 weeks. We conclude that patients with Plasmodium vivax, P. malariae and P. ovale infections had slightly elevated serum bilirubin, aminotransferase and alkaline phosphatase levels, and hypoalbuminemia. These minor abnormalities returned to normal within a few weeks after treatment with therapies based on artemisinin derivatives.


Subject(s)
Middle Aged , Male , Humans , Female , Animals , Adult , Adolescent , Treatment Outcome , Sesquiterpenes/therapeutic use , Serum Albumin , Plasmodium vivax/drug effects , Plasmodium ovale/drug effects , Plasmodium malariae/drug effects , Malaria, Vivax/drug therapy , Malaria/drug therapy , Liver Function Tests , Liver/physiopathology , Bilirubin/blood , Artemisinins/therapeutic use , Anti-Infective Agents/therapeutic use , Alanine Transaminase/blood
2.
Rev. colomb. gastroenterol ; 19(3): 171-177, sep. 2004. tab
Article in Spanish | LILACS | ID: lil-636182

ABSTRACT

Objetivos. Describir en pacientes que presenten dengue clásico o dengue hemorrágico los hallazgos, clínicos y pruebas de función hepática. Establecer si estas alteraciones pueden eventualmente servir para diferenciar dengue clásico de hemorrágico y de cuadro febriles que no sean dengue. Metodología. El diseño es descriptivo de corte transversal, en el que se observó el comportamiento de las pruebas hepáticas (AST, ALT, bilirrubinas, fosfatasa alcalina) en pacientes con diagnóstico de dengue clásico y dengue hemorrágico y además se hizo una exploración de asociación en estas pruebas. Análisis en Epiinfo 6.0. Resultados. Se ingresaron 32 pacientes que presentaban sintomatología compatible con dengue y la serología IgM positiva anti-dengue. Dengue hemorrágico: 13 (35%). Dengue clásico: 19 (51%). No dengue por serología negativa: 5 (14%) 18 (56%) femenino y 14 (44%) masculino. Los síntomas más frecuentemente hallados fueron fiebre 32 (100 %), cefalea 24 (75%), vómito 22 (69%). Manifestaciones hemorrágicas 4 (13%). No hubo síntomas de enfermedad hepática. El patrón de laboratorio de función hepática mostró: Bilirrubina total media: 0.56 mg/dl (0.44-0.68). Bilirrubina directa media: 0.27 mg/dl (0.20-0.34) Bilirrubina indirecta: Media: 0.31 mg/dl (0.20-0.42) Transaminasas AST: media: 165 U/L (101-229). ALT: media: 157 U/L (78-236). Fosfatasa alcalina: media: 300 U/l (254-346). La bilirrubina directa > 0.27 mg/dl, pudiera diferenciar entre dengue clásico y hemorrágico ya que el OR = 3.50. Sensibilidad: 53.8%. Especificidad: 94.7 y (VPP) = 87.5 %. También se observó que el valor de bilirrubina directa: > 0. 27 mg / dl puede diferenciar cuadro de dengue de aquellos que no son dengue con OR: 2.74. Sensibilidad: 40.6. Especificidad: 80 %. VPP: 92.9 %. Conclusiones. Las alteraciones en la función hepática en pacientes con dengue se presentan más en dengue hemorrágico y son moderadas. La bilirrubina directa pudiera ser un eventual predictor de dengue hemorrágico.


Objectives. This paper describes in patients with dengue fever or dengue hemorrhagic fever, the clinical findings and laboratory pattern of liver function. We’ll study if those abnormal levels differ between dengue fever and dengue hemorrhagic fever or use to show other non dengue fever. Methods. Design is cross sectional study in order to find pattern of liver involvement (AST, ALT, Bilirubins, Alkaline Phosphatase) in patients with dengue fever and dengue hemorrhagic fever, and explore association among that laboratory test. Results. We studied 32 patients who had classic dengue fever and serology IgM anti- dengue positive. Dengue hemorrhagic fever:13 (35%). Classic dengue fever: 19 (51%). Non dengue- serology negative: 5 (14 %). Female 18 (56%), male 14 (44%). The most common clinical findings were: fever 32 (100 %), headache 24 (75%), vomiting 22 (69%), bleeding 4 (13%).There were no clinical findings of liver disease. The laboratory pattern of liver function was: Bilirubin: mean 0.56 mg/dL (0.44-0.68), Direct Bilirubin: mean 0.27 mg/dL (0.20-0.34); Indirect Bilirubin: mean 0.31 (0.20-0.42); AST: mean 165 U/L (101-229); ALT: mean 157 (78-236); ALP: mean 300 (254-346). The Direct Bilirubin >0.27 can able to identify the infection as dengue hemorrhagic fever or classic dengue fever, OR = 3.50, Sensibility: 53.8 %, Specificity: 94.7 % and VPP =87.5%. The Direct Bilirubin: >0.27 mg /dL also can able to identify the infection as dengue fever or other fever causes no dengue. OR= 2.74, Sensibility: 40.6, Specificity: 80 %, VPP: 92.9 % Conclusions. The impact in liver function in patients with dengue was more important in dengue hemorrhagic fever, however liver profile showed that liver dysfunction was mildly elevated. The Direct Bilirubin should be useful to identify the infection as Dengue Hemorrhagic Fever or classic Fever.


Subject(s)
Humans , Male , Female , Dengue , Liver Function Tests , Severe Dengue
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