ABSTRACT
Traditional Chinese medicine(TCM) has the characteristics and complexities of multi-component, multi-target and multi-way. The study of TCM compound efficacy material basis is the core part in illuminating the effect and mechanism of TCM. So many methods were involved in the researches on material foundation including the effective part searching, compatibility and its disassembled prescriptions investigating based on pharmacological activity tracking in vivo; the association analysis between chemical fingerprints characterized by a variety of instruments and efficacy; serum pharmacochemistry and Chinmedomics based on metabolic processes in vivo; cell membrane chromatography and bionic technology based on activity discovering in vitro; and network pharmacology based on the computer simulation. The paper summarized the research methods in this field by consulting and concluding some document data of recent years, aiming to provide a theoretical foundation for studying on the effective material foundation of compound prescription of traditional Chinese medicine.
ABSTRACT
Qi-Gui-Yin (QGY) compound, which composes of five herbal medicines of Astragalus membranaceus (Fisch.) Bge., Angelica sinensis (Oliv.) Diels, Lonicera japonica Thunb., Artemisia annua L., and Polygonum cuspidatum Sieb.et Zucc., which is able to treat antibiotic-resistant bacteria with antibiotics, and also to delay or even reverse the bacterial resistance producing. However, QGY compound is a complex mixture. And it is very difficult to elaborate its material foundation. Therefore, chemical constituents in five herbal medicines were summarized through searching of the related literatures. And then, 170 kinds of bioactive ingredients were classi-fied in order to provide evidences for the study on chemical constituent of QGY compound and identify its mate-rial foundation of delaying drug resistance .