Skin flap transplantation combined with membrane induction technique for repair of long bone defects and soft tissue defects / 中国组织工程研究

BACKGROUND: Membrane induction technique for treating long bone defects has advantages of few complications, significant treatment efficacy and ease in operation. In previous studies, membrane induction technique was used to treat bone defect patients with good cartilage tissue, but there are few reports regarding bone defects with large area of cartilage tissue defect or accompanying infection. OBJECTIVE: To analyze the efficacy of flap transplantation combined with membrane induction technique for repairing long bone defects and soft tissue defects. METHODS: Fifteen patients with long bone defects and soft tissue defects who were treated in Affiliated Nanhua Hospital, University of South China from October 2016 to August 2018 were selected. They were aged (47.15±8.16) years. The soft tissue defect area was 5.1 cm x 3.4 cm-21.8 cm x 9.4 cm. The length of bone defect was 5.8-19.5 cm, with an average of (11.4±2.3) cm. The patients with mildly polluted wounds underwent debridement, external fixation of fracture, and filling bone cement in the bone defect area. Wounds were covered with local pedicle flaps or free flaps. Wound infection patients underwent vacuum sealing drainage, bone cement filling and flap surgery after infection was controlled. The second graft surgery was performed at 8 to 12 weeks after primary intention, and patients were followed up for 12 months. This study was approved by the Institutional Ethics Committee of Affiliated Nanhua Hospital, University of South China. RESULTS AND CONCLUSION: (1) Nine patients with mildly contaminated wounds were treated with external fixation after debridement, bone cement filling and flap transposition. No infection occurred. (2) Six patients with infection were treated with vacuum sealing drainage for 1 to 2 weeks. After the infection was controlled completely, bone cement filling and flap transplantation were conducted. All wounds were healed. (3) Fifteen patients achieved bone healing after second bone grafting. The healing time was between 8 and 12 months, with an average of (9.18±2.10) months. (4) These results suggest that skin flap transplantation combined with membrane induction technique can effectively treat patients with long bone defects and soft tissue defects.

Fractura expuesta de pierna con defecto óseo segmentario: reconstrucción con técnica de inducción de membrana tipo masquelet. A propósito de un caso / Exposed fracture of leg with a segmentary bone defect: reconstruction with masquelet or induced membrane technique. A clinical case

Las fracturas expuestas de tibia por alta energía se asocian a conminución, pérdida de stock óseo y daño de partes blandas. El manejo inicial debe incluir el aseo quirúrgico con desbridamiento adecuado. La evidencia actual sugiere realizar un manejo por etapas, conforme el estado de cobertura de partes blandas permita realizar la reconstrucción ósea definitiva. Los defectos óseos segmentarios críticos agregan el problema de requerir de una técnica de reconstrucción ósea para disminuir riesgo de infección, retardo en la consolidación y no unión. Se presenta un caso clínico con defecto óseo crítico de tibia con falta de cobertura de partes blandas, tratado con colgajo de sural anterógrado y técnica de inducción de membrana tipo Masquelet.

High energy, exposed fractures of the tibia are associated with comminution, bone loss, and soft tissue damage. It should be managed initially with surgical cleaning and debridement. If the soft tissue envelope permits definitive osseus reconstruction, the evidence at present suggests managing it in stages. Critical segmentary bone defects require osseous reconstruction for reduction of infection risk, consolidation delay and nonunion. We present a clinical case with a critical bone defect and significant soft tissue loss treated with an anterograde sural flap and induced membrane or Masquelet technique.