ABSTRACT
Objective: To prepare hydrophobic nano-CaCO3 modified by stearic acid and to study its application in spray drying power of angelica. Methods: The stearic acid was used on the surface characteristic of nano-CaCO3, and the modified and unmodified nano-CaCO3 was analyzed and investigated by means of oil absorption value, activation index (H), angle of repose, transmission electron microscopy (TEM), and Fourier transforms infrared (FTIR). The effect of modified nano-CaCO3 on moisture absorption, fluidity, and in vitro dissolution of ferulic acid in spray drying power of angelica were investigated, comparing with silicon dioxide and unmodified nano-CaCO3. Results: FTIR analysis showed that stearic acid has attached to CaCO3 surface. Powder flow and powder moisture absorption were improved in modified nano-CaCO3 and the effect was better than silica dioxide and unmodified nano-CaCO3. The in vitro dissolution of ferulic acid was not affected. Conclusion: The application of the nano-CaCO3 modified by stearic acid in the spray drying power of Chinese materia medica deserves to be studied further.
ABSTRACT
OBJECTIVE: To prepare hydrophobic nano-CaCO3 by nano-CaCO3 and stearic acid. And to prepare tripterine solid dispersion using the new material as a carrier by solvent method. METHODS: The structure of modified nano-CaCO3 was characterized by TEM, DSC, XRD and FTIR. Meanwhile the solid dispersions were characterized by SEM, DSC, XRD and FTIR, and the in vitro dissolution test of tripterine was performed. RESULTS: When the ratio of drug to modified nano-CaCO3 was 1:4, tripterine could be dispersed amorphously in the carrier. And the accumulative drug-release percentage in vitro at 0.5 h was 7.05%. With the time increasing, the accumulative drug-release percentage also increased to 90.03% at 12 h. Moreover, tripterine solid dispersion had a better sustained release effect. CONCLUSION The nano-CaCO3 modified by stearic acid can be used as controlled-release carrier for tripterine.