ABSTRACT
OBJECTIVE: To provide a review of the research progresses of the multivesicular liposomes as a carrier of the protein and peptide drugs. METHODS: To summarize and analyze the researches of the protein/peptide drugs encapsulated in multivesicular liposomes according to the related articles. RESULTS AND CONCLUSION: A major problem in the clinical usage of protein and peptide drugs is frequent injection, for they have poor stability, short half-life time and high clearance. This challenge has been successfully met by the multivesicular liposomes encapsulating the peptide and protein drugs. The new liposome uses depot foam technology to achieve high loading sufficient and encapsulation, and they are very competent carriers of the compounds, especially the water-soluble drugs.
ABSTRACT
Objective:To perform in vitra MR imaging and compare the differences between DepoGd and Gd-DTPA in signal intensity using multivesicular liposome(DepoFoam)as the carrier of rutine magnetic resornance contrast media.Methods:Lipos ome such as cholesterol was mixed with Gd-DTPA,and rotation speed of centrifuge was adjusted to get DepoGd particles with certain diameter.The three different liquors named X,Y and Z(Gd-DTPA liquor,17 ?m DepoGd liquor and 22 ?m DepoGd liquor) were prepared into 4 kinds of concentrations spectively.Signal intensity of these liquors was measured with MR scanner,and statistical analysis was done consequently.Results:Diameters of most of the DepoGd particles got through the forementioned method with the envelop rate of 50%.Signal intensity of different liquors with the same concentration showed no statistical difference,which means signal intensity of DepoGd and Gd-DTPA active compound with the same mole concentration showed no statistical difference in vitra MR test.Conclusion:DepoFoam can carry conventional MR contrast agent with high envelop rate and no obvious difference was showed in signal intensity.