1.
Chinese Traditional and Herbal Drugs
;
(24): 474-477, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-855651
ABSTRACT
Objective: Optimizing the formula and preparation of β-elemene- polybutylcyanoacrylate nanoparticles (β-ELE-PBCA-NP). Methods: With polybutylcyanoacrylate (PBCA) as the drug-loaded material, β-ELE-PBCA-NP was prepared by interfacial polycondensation. The preparation conditions were optimized by single factor design and the formula was optimized by orthogonal design with entrapment efficiency (EE) as index. EE of β-ELE-PBCA-NP was determinated by RP-HPLC. Results: Under the optimal conditions, the prepared NPs were round and regular in shape without adhesions with average particle size of 254 nm and EE of 90.17%. Conclusion: The optimized technology in this experiment is stable and feasible.