Syringocystadenoma Papilliferum arising from a nevus sebaceus mimicking squamous cell carcinoma in a Filipino female: A case report

Introduction@#Syringocystadenoma papilliferum (SCAP) is a relatively rare benign adnexal skin tumor which can manifest in a variety of clinical forms. Nearly one-third of cases are known to develop within a pre-existing nevus sebaceus (NS). The peculiar feature of this case was the appearance of a large exophytic tumor within a congenital verrucous plaque, which raised the suspicion of a malignant transformation. This is a case of a young Filipino adult with an unusual presentation of syringocystad- enoma papilliferum in a nevus sebaceus mimicking squamous cell carcinoma.@*Case report@#A 27-year-old Filipino female presented a persistently enlarging exophytic pedunculated cribriform tumor within a congenital verrucous plaque on the left temporal area. The tumor started to appear when she was 20 years old. One month prior to consult, it rapidly increased in size and bled on gentle manipulation. She has neither comorbidities nor any family history of a similar condition. Her physical examination was normal, with no palpable lymphadenopathies. The biopsy showed syringo- cystadenoma papilliferum on a nevus sebaceus. She underwent carbon dioxide (CO2 ) laser excision under local anesthesia. The procedure was uneventful and the patient is on regular follow-up and close monitoring for any possible malignant change or recurrence.@*Conclusion@#A case of syringocystadenoma papilliferum on a nevus sebaceus mimicking squamous cell carcinoma in a Filipino female treated with carbon dioxide laser excision was presented. The unusual presentation of SCAP can mimic malignancy and histopathologic evaluation is warranted to rule out malignant transformation for proper management.

Trichoblastoma and Compound Nevus Arising from Nevus Sebaceus / 대한피부과학회지

Nevus sebaceous is a common congenital cutaneous hamartoma occurring mainly on the face and scalp. It is well known that secondary neoplasms can be easily observed in the primary lesion. However, a case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous has not been previously reported. A 26-year-old woman presented with a well-demarcated atrophic skin-colored plaque on her scalp from birth. On the plaque, a black dome-shaped round nodule and a brownish nodule with irregular margins were found one week previously without subjective symptoms. Histopathological examination of the central plaque lesion revealed epidermal hyperplasia and hyperplasia of the sebaceous glands and eccrine glands. In addition, ectopic, dilated apocrine glands were revealed in the lower dermis, and the hair follicles remained small and primordial, consistent with nevus sebaceous. A section of the black nodule showed palisading basaloid cells surrounded by abundant fibrous stroma. Nests of nevus cells were found at the dermo-epidermal junction and dermis in the brownish nodule. Based on these findings, the black nodule and brownish nodule were diagnosed as trichoblastoma and compound nevus, respectively. Herein, we report an interesting case of trichoblastoma and compound nevus concurrently arising from nevus sebaceous, which is, to our knowledge, the first such report in the dermatologic literature.

A Case of Trichoblastoma, Tumor of the Follicular Infundibulum, Sebaceoma, and Sebaceous Hyperplasia Arising from Nevus Sebaceus / 대한피부과학회지

Nevus sebaceus is a congenital hamartoma with epidermal, follicular, and apocrine elements. Several skin appendage tumors can evolve secondarily from nevus sebaceus. Two different tumors often develop simultaneously on a nevus sebaceus lesion, but the growth of more than two tumors is rare. Herein, we report a case of four appendage tumors including trichoblastoma, tumor of the follicular infundibulum, sebaceoma, and sebaceous hyperplasia within a single nevus sebaceus lesion on the face of a 76-year-old female.

Clear Cell Basal Cell Carcinoma Arising in Pre-existing Nevus Sebaceus / 대한피부과학회지

No abstract available.

Basal Cell Carcinoma Arising in an Agminate Nevus Sebaceous / 대한피부과학회지

No abstract available.

Comments to "A Case of Squamous Cell Carcinoma Developing in a Nevus Sebaceus of the Scalp" / 대한피부과학회지

No abstract available.

Two Concurrent Facial Epidermal Nevi without Systemic Abnormalities: Nevus Sebaceus and Nevus Comedonicus

Epidermal nevi (EN) are hamartomatous lesions derived from epidermal components originating from pluripotent cell mutations. They have been categorized according to their predominant component. The existence of >2 types of EN concurrently within a single area or within contiguous areas has been rarely reported. This report describes the case of simultaneous presence of a yellowish plaque on the left medial canthus and an aggregation of closed comedo-like papules on the right side of the cheek of a 15-year-old girl.

A Case of Squamous Cell Carcinoma Developing in a Nevus Sebaceus of the Scalp / 대한피부과학회지

Nevus sebaceus is frequently complicated by development of a variety of other benign skin tumors. On the other hand, malignant skin tumors are rarely observed in associated with nevus sebaceous. The most common benign skin tumor developing in nevus sebaceus is trichoblastoma, while the most common malignant skin tumor is basal cell carcinoma. However, cases of squamous cell carcinoma developing within nevus sebaceous are rare. A 42-year-old man presented a solitary 3x3-cm sized hemorrhagic, crusted, verrucous mass on the left occipital scalp, which was congenital. He visited our clinic due to the mass rapidly enlarging over the past 3 years and due to bleeding of the mass in the past 3 months. Histopathologically, the tumor showed typical findings of well-differentiated nevus sebaceus and squamous cell carcinoma. We herein report a case of squamous cell carcinoma developing in nevus sebaceous.

Squamous Cell Carcinoma and Basal Cell Carcinoma Simultaneously Arising in a Nevus Sebaceus: A Case Report

PURPOSE: Nevus sebaceus is a congenital hamartomatous lesion, typically involving head and neck. Various benign and malignant neoplasms can develop in association with nevus sebaceus. We report a case of simultaneous occurrence of squamous cell carcinoma and basal cell carcinoma in nevus sebaceus. METHODS: A 73-year-old man presented with erythematous to black verrucous nodules on the right subauricular area. The upper part was accompanied with inflammation and ulceration, and no specific findings suspicious for malignant degeneration were found in the lower part preoperatively. The mass was totally excised and the defect was directly closed. Lymph nodes were not involved on concomitant neck dissection. RESULTS: Histopathologic examination confirmed the presence of squamous cell carcinoma in the upper part and basal cell carcinoma in the lower part of a nevus sebaceus. Negative margins were achieved on resection. No clinical problems were found during the 3-month follow-up period. CONCLUSION: We experienced a rare case of simultaneous occurrence of squamous cell carcinoma and basal cell carcinoma within the same nevus sebaceus. Because patients with nevus sebaceus have risk of malignant changes, surgical excision and work-up for recurrence and metastasis should be considered in suspicious cases. And even in a totally asymptomatic case, the possibility of occult secondary cancer should be informed before surgery in aged patients.

Multiple Nevus Sebaceous Occurring on the Scalp and on the Contralateral Side of the Face

Nevus sebaceous (NS) is a benign neoplasm occurring mainly on the face and scalp. It commonly occurs as a solitary, well-demarcated lesion. This paper presents a case of multiple nevus sebaceous, which presented as multiple lesions occurring on the temporal scalp and on the contralateral side of the chin. Multiple NS have only rarely been reported.

A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus

Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp.

A Case of Nevus Sebaceus Associated with Sebaceous Adenoma, Basal Cell Epithelioma, and Eccrine Poroma / 대한피부과학회지

Nevus sebaceous (NS) is a congenital hamartomatous disorder of the skin and its adnexa, usually involving the scalp or the face. It characteristically evolves and changes morphology with time. Various benign and malignant neoplasms can develop in association with NS. Most common benign or malignant tumors developed within the NS are syringocystadenoma papilliferum and trichoblastoma or basal cell epithelioma. We now report a case of NS associated with sebaceous adenoma, basal cell epithelioma, and eccrine poroma in a 63 year old male.

A Case of Nevus Sebaceus Associated with Sebaceous Adenoma, Basal Cell Epithelioma, and Eccrine Poroma / 대한피부과학회지

Nevus sebaceous (NS) is a congenital hamartomatous disorder of the skin and its adnexa, usually involving the scalp or the face. It characteristically evolves and changes morphology with time. Various benign and malignant neoplasms can develop in association with NS. Most common benign or malignant tumors developed within the NS are syringocystadenoma papilliferum and trichoblastoma or basal cell epithelioma. We now report a case of NS associated with sebaceous adenoma, basal cell epithelioma, and eccrine poroma in a 63 year old male.

A Case of Extraocular Sebaceous Carcinoma Arising from Nevus Sebaceus / 대한피부과학회지

Sebaceous carcinoma (SC) is a slow-growing, locally aggressive tumor with the high potency of metastatic spread. This neoplasm frequently arises from the sebaceous glands of the eyelid and exceptionally from extraocular sites. Approximately one-quarter of all reported cases of SC are extraocular. We observed a 42-year-old woman with an crusted erythematous to brownish plaque on her scalp. The biopsy specimen showed that multiple lobules were composed of foamy-cytoplasmic cells and sebocytes which show pleomorphism and atypia. For the immunohistochemistry, abundant tumor cells (with the expressions of epithelial membrane antigens and cytokeratin) were found within the masses. We present here a case of SC of the scalp arising from a previous lesion clinically compatible with a nevus sebaceous.

Desmoplastic Trichilemmoma Arising in a Nevus Sebaceus

PURPOSE: Desmoplastic trichilemmoma is a rare variant of trichilemmoma. Histologically, it has a typical characteristic of trichilemmoma with epithelium of central portion and dense fibrous interstitium. There are only 4 reported cases of desmoplastic trichilemmoma arised in a nevus sebaceus, so we present a case of desmoplastic trichilemmoma arised in a nevus sebaceus with literature review. METHODS: A 46-year-old female was clinically diagnosed as nevus sebaceous on left side of the forehead. Considering the facial contour, the mass was totally excised elliptically and direct closure was feasible with undermining subcutaneous layer. RESULTS: Pathology report confirmed desmoplastic trichilemmoma developed from a nevus sebaceus and all tumor margins were negative. There were no evidences of tumor recurrence after surgical treatment. CONCLUSION: Desmoplastic trichilemmoma developed from a nevus sebaceus is a very rare tumor. Variant tumors can be developed from nevus sebaceus, so surgeon should be cautious in excising the mass totally and confirm the final pathology report.

Three Cases Showing Combined Features of Syringocystadenoma Papilliferum andTubular Apocrine Adenoma Superimposed on Nevus Sebaceus / 대한피부과학회지

Both syringocystadenoma papilliferum and tubular apocrine adenoma are benign skin appendage tumors of apocrine differentiation. They may be isolated and easily discernible, but in some cases, it is difficult to differentiate them into separate entities or diseases with overlapping features. We herein report three cases showing features of both syringocystadenoma papilliferum and tubular apocrine adenoma simultaneously. They presented as a 20-year-old woman with linear verrucous erythematous plaque with grouped papules on the left sideburn area, a 64-year-old man with verrucous plaque on the right temporal scalp, a 48-year-old man with verrucous erythematous patch on the occipital scalp and commonly showed syringocystadenoma and tubular apocrine adenoma. All cases had been present since birth and also showed similar histopathologic features as follows; occasional fetal hair germ-like immature pilosebaceous structures or somewhat hypertrophied sebaceous glands directly connecting to surface epidermis, suggesting the association with nevus sebaceus in a variable degree.

A Case of Verrucous Epidermal Nevus Contiguous with Nevus Sebaceus / 대한피부과학회지

During normal development of skin, pluripotential cells give rise to keratinocytes, sebaceus glands, hair follicles, apocrine glands, and eccrine glands. In epidermal nevi, these components emerge in an abnormal mixture within a circumscribed site. Many authors have categorized epidermal nevi according to their predominant component, however, there is often notable overlap which occurs within a single area or within contiguous areas. An 11-year-old female patient presented with linearly-arranged, multiple yellowish papules and a dark-brown colored verrucous plaque on the left occipital area, which had been present since birth. From the histopathological findings, the papules were diagnosed as nevus sebaceus and the plaque was diagnosed as verrucous epidermal nevus. Our present case gives support to the view that epidermal nevi have a spectrum of manifestations, including verrucous epidermal nevi and nevus sebaceus. To the best of our knowledge, this is the first report of a verrucous epidermal nevus contiguous to a nevus sebaceus in the Korean dermatological literature.

A Case of Trichilemmoma Arising in Nevus Sebaceus / 대한피부과학회지

In adulthood, nevus sebaceus is frequently associated with trichoblastoma and syringocystadenoma papilliferum. However, trichilemmoma rarely develops in nevus sebaceus. We report a case of nevus sebaceus associated with trichilemmoma in a 45-year-old female patient. She had three erythematous-to-normal skin-colored, well-demarcated verrucous-surfaced nodules on the right temporal area of the scalp, which were pea-to-bean sized. The histologic findings revealed characteristic features of nevus sebaceus. In the epidermis of the lesion, there were lobulated tumors consisting of clear cells with palisading columnar basal cells in the margin, and these were surrounded by a prominent basement membrane. The findings were consistant with trichilemmoma arising in nevus sebaceus.

Sebaceous Carcinoma Arising from Nevus Sebaceus / 대한피부과학회지

Nevus sebaceus is a hamartoma of both epithelial and non-epithelial components, which that undergoes age-related change. It commonly affects the head and neck, particularly the scalp. In 10-20% of nevus sebaceus cases, secondary benign or malignant neoplasms such as syringocystadenoma papilliferum, trichoblastoma or basal cell carcinoma occur between 40-80 years of age. In only rare instances does a sebaceous carcinoma develop within a nevus sebaceus. To our knowledge, only 3 cases of sebaceous carcinoma in nevus sebaceus have been reported in the Korean dermatologic literature. We present a case of a sebaceous carcinoma arising from nevus sebaceus in a 46-year-old Korean man.

A Case of Nevus Sebaceus, Accompanied by Syringocystadenoma Papilliferum, a Basal Cell Carcinoma-like Tumor, Sebaceous Epithelioma, Apocrine Adenoma and Tumor of Follicular Infundibulum, with Repair by Subgaleal-periosteal Fixation / 대한피부과학회지

Nevus sebaceus is well-known for its potential to develop both benign and malignant neoplasms of epidermal and adnexal origin. We found 5 tumors including syringocystadenoma papilliferum, a basal cell carcinoma-like tumor, sebaceous epithelioma, a tumor of follicular infundibulum and apocrine adenoma within a single nevus sebaceus lesion in a 37-year-old man. This is a rarely reported case of a nevus sebaceus lesion containing a basal carcinoma-like, trichoblastoma-like skin tumor and tumors of follicular infundibulum. The lesion was treated by wide excision and repaired with subgaleal-periosteal fixation which resulted in good wound healing.