ABSTRACT
Background: Patients with inflammatory bowel disease (IBD) often have associated conditions which may benefit from treatment with non-steroidal anti-inflammatory drugs (NSAIDs) or selective cyclo-oxygenase-2 (COX-2) inhibitors. However, evidence has suggested there may be an association between COX- inhibition and relapse in IBD, which leads to clinicians being reluctant to prescribe these agents. Aims: The aim of this review is to review the possible biological mechanisms, linking NSAIDs and IBD-relapse and current knowledge on the possible association of NSAIDs and clinical relapse in IBD. Results: IBD relapse due to NSAID use is most likely due to prostaglandin inhibition via dual COX inhibition, although the topical effect of NSAIDs on the intestine may also play a role. The evidence for an association between NSAIDs and IBD relapse is contradictory and generally weak, but it is likely a small percentage of patients relapse when taking NSAIDs, but it is not known which patients are at risk. Mixed results have also been obtained from studies examining COX-2 selective agents; although a single randomized controlled-trial showed that celecoxib is safe in ulcerative colitis in the short term. Conclusions: At present the data are contradictory and most published studies have serious flaws. Overall the association between use of NSAIDs and IBD-relapse seems rather weak, Cyclooxygenase inhibitors should not be withheld from stable IBD patients, if clinically indicated and appropriate cautions and monitoring are used. Celecoxib would seem a sensible first choice. Further studies are needed to help identify which patients are at risk of relapse with NSAIDs.
ABSTRACT
We evaluated the effect of 0.1% Pranoprofen,a non-steroidal antiinflammatory drug, and therapeutic contact lens in the pain control after refractive surgeries.One hundred and two patients undergone PRK were subdivided into 4 groups: 27 patients treated with placebo (Group 1), 28 patients with Pranoprofen (Group 2), 30 patients with therapeutic contactlens (Group 3) and 17 patients with Pranoprofen and contact lens (Group 4). Forty-seven patients undergone LASIK were subdivided into 2 groups: 27 patients treated with placebo (Group 5) and 20 patients with Pranoprofen (Group 6). We recorded and analyzed visual analogue scale, 6 questions about pain and pain scores during postoperative 48 hours to evaluate the degree of pain. In PRK groups, analgesic effect was evident in groups using Pranoprofen (Group 2,4) compared to the groups not using the drugs (Group 1,3). The analgesic effect was augmented by the combined use of therapeutic contact lenses along with Pranoprofen (Group 4). Pranoprofen did not have an adverse effect on corneal epithelial wound healing.In LASIK groups,pain control was more effective in Pranoprofen using groups. However, it was not statistically significant. In conclusion, 0.1%Pranoprofen can be used effectively to reduce postoperative pain following PRK and LASIK procedures and the analgesic effect of the drug can be augmented by the combined use of therapeutic contact lenses.
Subject(s)
Humans , Contact Lenses , Keratomileusis, Laser In Situ , Ophthalmic Solutions , Pain, Postoperative , Refractive Surgical Procedures , Wounds and InjuriesABSTRACT
Ferulof en ( FL, 45mg and 200mg/kg im ) showed marked antipyretic effect on rabbit fever induced by typho-paratyhoid vaccine and on rat fever induced by yeast powder suspension respectively. Their potency and action phase were similar to those of aspirin ( 35mg and 100mg/kg) . Furthermore, it blocked the action potential of sciatic nerve in toad to some extent and had a certain local anesthetic effect on guinea pigs in intradermic wheal test, but much weaker than procaine and lidocaine at the same concentration. It had no obvious influence on corneal reflex in rabbits.It can be concluded from these findings that together with the results of previous paper the findings of this paper further indicated FL may be proved to be a new antiinflammatory, antipyretic and analgesic drug.
ABSTRACT
Nimesulide is a new non-steroidal anti-inflammatory drug (NSAID). In this paper, its antiinflammatory, analgesic and antipyretic effects in mice rat or rabbit were evaluated. Nimesulide inhibited the ear oedema induced by croton oil in mice (ED50=49. 2 mg ? kg-1). It inhibitated rat hind paw oedema induced by carragreenin (ED50= 2.75 mg ? kg-1). Oral dose (0. 6 mg ? kg-1) showed sup-pressive effect on adjuvant arthritis in rat. Oraldose (100 mg ? kg-1) decreased writhing induced by acetic acid. Similar effect was observed in hot plate test on mice. Nimesulide (2 mg ? kg-1) decreased body tempreture elevated by injecting peptone in rabbit (P
ABSTRACT
Antiinf lammatory effects of Ferulofen ( FL ) were shown by im or ip on xylene-induced swellingof mice ear, carrageenin produced edema of hind paw in rats, and decreased volume of pleural exud- ate on carrageenin-induced acute pleurisy of rats, FL also inhibi-tied the proliferating granuloma by croton oil. The above dose r-ange in 50-100mg/kg im or ip which presented a good dose-effect relationship, FL also inhibited the mice writhing caused by H AC & tail-flick response to 1 light irradiation, suggesting its strong analgesic effect. In addition, its anticancer effect in vitro ( carcinoma of Ehlrich ascitis)was better than that in vivo ( Sl80 sarcoma) in mouse. So FL may be considered to be a promising new type of non-steroidal antiinflammatory & anticancer drug ,worthy of further reseaching & exploring in the future.