ABSTRACT
BACKGROUND: The ocular adnexal extranodal marginal zone B-cell lymphoma has been known as the 2nd most common extranodal marginal zone B-cell lymphoma, which presents as the dermatologic symptom and sign, such as orbital mass and swelling. However, the ocular adnexal extranodal marginal zone B-cell lymphoma has been few reported in the dermatologic literature. OBJECTIVE: We described the clinical and histopathological features of ocular adnexal extranodal marginal zone B-cell lymphoma from the perspective of dermatology. METHODS: Ninety-nine cases of ocular adnexal extranodal marginal zone B-cell lymphoma patients were included in this study, among the 352 patients, who were diagnosed with extranodal marginal zone B-cell lymphoma between March 1998 and February 2011. Their medical records and histopathologic slides were retrospectively reviewed. RESULTS: Among the 352 patient of extranodal marginal zone B-cell lymphoma, ocular adnexal extranodal marginal zone B-cell lymphoma occurred in 99 patients (28.1%). The ratio between male and female was 1:2, and the mean age was 50 years (range; 20~54 years). Ocular adnexal extranodal marginal zone B-cell lymphoma presented as orbital mass (39.1%), conjunctival injection (25.6%), orbital swelling (19.5%), and etc. In most patients, lesions were located in conjunctiva (63.8%) or orbit (14.5%). 76.7% of patients presented with Ann Arbor stage I disease. Relapses occurred in 8.4% of patients during the follow-up period. CONCLUSION: When dermatologists meet patients presenting with orbital mass and swelling, dermatologists consider the possibility of ocular adnexal extranodal marginal zone B-cell lymphoma and consultation with the ophthalmologists.