ABSTRACT
AIM: To analyze the clinical and histopathological composition of orbital tumors and tumor-like lesions.METHODS: Retrospective case-series study. The clinical histopathological data of 699 cases(707 eyes)with orbital tumor and tumor-like lesions who treated in the orbital disease and ophthalmic plastic department of Tianjin Eye Hospital between January 2010 and December 2020 were collected. All the pathology diagnosis results were divided into three categories which were benign tumor, borderline tumor and malignant tumor according to the eighth edition of the American Joint Committee on Cancer staging system and the 2018 World Health Organization Classification of tumors of the eye. All cases were divided into four groups according to age, including 0～17 years old, 18～39 years old, 40～59 years old, 60 years and above. The histological composition of each group was analyzed.RESULTS: Among the 699 cases(707 eyes), 311 patients(316 eyes)were male and 388 patients(391 eyes)were female. The patient's age at diagnosis ranged from 1 to 84 years(mean 39.9±2.2)years. The right orbit was involved in 307 patients, the left orbit in 384 patients, and 8 patients in bilateral orbit. There were 598 patients(604 eyes, 85.6%)with benign tumor and tumor-like lesions, 7 patients(7 eyes, 1.0%)with borderline tumor, and 94 patients(96 eyes, 13.4%)with malignant tumors. The top 5 benign tumor and tumor-like lesions were cavernous hemangioma(110 cases, 15.7%), dermoid cysts(96 cases, 13.7%), pleomorphic adenomas(54 cases, 7.7%), inflammatory pseudotumors(38 cases, 5.4%), and schwannomas(29 cases, 4.1%)respectively. The top 5 borderline and malignant tumors were non-Hodgkin lymphomas(42 cases, 41.6%), solitary fibrous tumors(12 cases, 11.9%), adenoid cystic carcinomas(11 cases, 10.9%), metastatic tumor(9 cases, 8.9%), and rhabdomyosarcoma(8 cases, 7.9%), respectively. Among the common orbital benign tumors and tumor-like lesions, cavernous hemangioma and pleomorphic adenoma showed a female predominance. Among the common borderline and malignant tumors, non-Hodgkin lymphoma and mesenchymal chondrosarcoma showed a male predominance. The most common benign and malignant tumors were dermoid cysts, rhabdomyosarcomas respectively in group under 18 years old. And dermoid cysts and solitary fibrous tumors were the most common benign and malignant tumors respectively in patients between 18 and 39 years old. Cavernous hemangioma and non-Hodgkin lymphomas were the most common benign and malignant tumors respectively in patients between 40 and 59 years old. While cavernous hemangioma and non-Hodgkin lymphomas were the most common benign and malignant tumors respectively in cases over 60 years old.CONCLUSION: Most orbital tumors and tumor-like lesions are benign. The most common benign orbital tumor is cavernous hemangioma, followed by dermoid cyst. Non-Hodgkin lymphoma is the most common malignant orbital tumor.
ABSTRACT
@#Heme oxygenase-1(HO-1)is one of the most widely distributed antioxidant enzymes in the body, which can catalyze the metabolism of heme to biliverdin, iron ion and carbon monoxide, and finally exert anti-inflammatory and anti-inflammatory effects. Oxidation and the like. In diseases such as corneal disease, cataract, glaucoma, and diabetic retinopathy, HO-1 expression is up-regulated to protect tissues from oxidative damage, and its overexpression is closely related to the occurrence and development of ocular tumors. This article reviews the recent research progress between HO-1 and its metabolic end products and ophthalmic diseases.
ABSTRACT
The clinical value of whole body positron emission tomography/computed tomography (PET/CT) as an imaging tool in diagnosis of ophthalmic tumors was investigated.The retrospective observational case series were performed on the patients with suspected ophthalmic tumors who underwent whole body PET/CT.The golden standard of diagnosis was the final pathological diagnosis or the results of long-term follow-up for patients without surgery/ biopsy.PET/CT findings were compared with the golden standard.The sensitivity,specificity,accuracy and positive likelihood ratio of PET/CT in the detection of ophthalmic tumors were calculated.The clinical application of PET/CT in different types of ophthalmic tumors was evaluated.The results showed that 30 patients (18 males and 12 females) with a mean age of 43.0 years (range 4-63 years) were collected.The mean sizes of orbital tumors and intraocular tumors were 26.8 mm×17.8 mm and 11.2 mm×6.1 mm,respectively.The overall sensitivity,specificity,accuracy and positive likelihood ratio of whole body PET/CT in ophthalmic tumors were 76.5％,71.4％,75.0％ and 2.67,and were 62.5％,100％ and 70.0％ in intraocular tumors,and those were 100％,60.0％ and 84.6％ in orbital tumors,respectively.PET/CT findings were applied to help make appropriate treatment options in 27 out of 30 patients (90.0％),and 12 (40.0％) patients changed the treatment strategy.False negative results in 4 cases and false positive results in 2 cases were observed in this series.It was suggested that PET/CT was an effective imaging modality in detecting,diagnosing and developing therapeutic schedule for patients with ophthalmic tumors.It was more sensitive and accurate for detecting orbital tumors than for detecting intraocular tumors.
ABSTRACT
The clinical value of whole body positron emission tomography/computed tomography (PET/CT) as an imaging tool in diagnosis of ophthalmic tumors was investigated.The retrospective observational case series were performed on the patients with suspected ophthalmic tumors who underwent whole body PET/CT.The golden standard of diagnosis was the final pathological diagnosis or the results of long-term follow-up for patients without surgery/ biopsy.PET/CT findings were compared with the golden standard.The sensitivity,specificity,accuracy and positive likelihood ratio of PET/CT in the detection of ophthalmic tumors were calculated.The clinical application of PET/CT in different types of ophthalmic tumors was evaluated.The results showed that 30 patients (18 males and 12 females) with a mean age of 43.0 years (range 4-63 years) were collected.The mean sizes of orbital tumors and intraocular tumors were 26.8 mm×17.8 mm and 11.2 mm×6.1 mm,respectively.The overall sensitivity,specificity,accuracy and positive likelihood ratio of whole body PET/CT in ophthalmic tumors were 76.5％,71.4％,75.0％ and 2.67,and were 62.5％,100％ and 70.0％ in intraocular tumors,and those were 100％,60.0％ and 84.6％ in orbital tumors,respectively.PET/CT findings were applied to help make appropriate treatment options in 27 out of 30 patients (90.0％),and 12 (40.0％) patients changed the treatment strategy.False negative results in 4 cases and false positive results in 2 cases were observed in this series.It was suggested that PET/CT was an effective imaging modality in detecting,diagnosing and developing therapeutic schedule for patients with ophthalmic tumors.It was more sensitive and accurate for detecting orbital tumors than for detecting intraocular tumors.
ABSTRACT
AIM: To investigate the application value of contrast -enhanced ultrasound ( CEUS) and analysis software for intra-ocular tumor diagnosis. METHODS:Retrospective analysis for 90 cases (90 eyes) with intra- ocular tumor with CEUS examination, and all cases were confirmed by pathology after surgery or clinical comprehensive diagnosis and follow-up. RESULTS: Choroidal hemangioma, choroidal melanoma, choroidal metastatic carcinoma had obvious different CEUS enhancement pattern, quantitative analysis indexes of those tumors by imaging analysis software were significantly different (PCONCLUSION: The CEUS can provide quantitative analysis for intra - ocular tumor with preferable clinical application value.
ABSTRACT
The purpose was to evaluate the effectiveness of beta-radiation with strontium-90 as single modality treatment of canine third eyelid squamous cell carcinoma (SCC). Nine dogs diagnosed with third eyelid SCC were treated with strontium-90. Radiation therapy was administered in four fractions of 100cGy per site every four days and at a depth of 0.2cm (Strontium-90 build' up) in each fraction. Radiation with beta therapy was well tolerated in all animals with no occurrence of radiation induced cataracts. In all cases, there were increased signs of conjunctival inflammation around the mass, which subsided with topical anti-inflammatory. Two dogs required surgical treatment for local tumor recurrence at 150 days and 352 days. In the remaining seven cases, disease free interval ranged from 1239 days to 2555 days. Beta therapy using 90Sr may be a valid alternative for the treatment of third eyelid SCC in dogs.
O objetivo foi avaliar a eficácia da betaterapia com estrôncio-90 como modalidade única de tratamento em carcinomas de células escamosas (CEC) da terceira pálpebra de cães. Nove cães foram diagnosticados com CEC de terceira pálpebra, que foram tratados com estrôncio-90. A radioterapia foi administrada em quatro frações de 100cGy por local, a cada quatro dias e a uma profundidade de 0,2cm em cada fração. A betaterapia foi bem tolerada por todos os animais, sem ocorrência de catarata induzida pela radiação. Em todos os casos, houve um aumento dos sinais de inflamação da conjuntiva ao redor da neoformação, as quais cederam com o uso de anti-inflamatório tópico. Em dois cães houve a necessidade de tratamento cirúrgico, pois houve recorrência local do tumor aos 150 dias e aos 352 dias. Nos outros sete casos, o intervalo livre de doença variou entre 1.239 dias e 2.555 dias. Betaterapia usando 90Sr pode ser uma alternativa válida para o tratamento do CEC da terceira pálpebra em cães.
ABSTRACT
Se presentan dos casos de pacientes jóvenes VIH negativos, clínicamente inmunocompetentes, sin antecedentes de exposición actínica prolongada ni riesgo ocupacional, con diagnóstico de carcinoma escamoso de conjuntiva. Presentación inusual en este tipo de lesión que se caracteriza por ser más frecuente a partir de la sexta década de vida, en personas expuestas a las radiaciones ultravioletas o con inmunocompromiso. Su incidencia varía entre 0,13 y 1,9 casos por 100 000 habitantes y ocupa el segundo lugar en frecuencia de los tumores malignos oculares. Se realizó biopsia excisional amplia con margen de 5 mm, crioterapia en las márgenes de la lesión e injerto de membrana amniótica en ambos casos, sin recidiva tumoral en dos años de evolución.
Two cases of young HIV-negative clinically immunocompromised patients, with no history of prolonged actinic exposure or occupational risk, and diagnosed with squamous cell carcinoma of the conjunctiva were presented. This is an unusual presentation in this type of injury that is more frequent after 60 years of age in people exposed to ultraviolet radiation or immunocompromised. Its incidence ranges 0,13 to 1,9 cases per 100,000 pop and ranks second infrequency of ocular malignancies. Excisional biopsy was performed with a 5 mm wide margin, cryotherapy in the borders of the lesion and amniotic membrane grafting were also performed in both cases, without tumor recurrence after two years of evolution.
Subject(s)
Humans , Adolescent , Biopsy/methods , Carcinoma, Squamous Cell/diagnosis , HIV , Eye Neoplasms/epidemiology , Amnion/injuriesABSTRACT
AIM: To analyze the composition, distribution and characteristics of the elderly primary ocular tumors. METHODS: This was a retrospective study and all 504 cases with primary ocular tumors aged 60 years or older were collected in Shanxi Eye Hospital, during the year 2000- 2012. The onset age, location and pathological pattern were analyzed. RESULTS: There were 346 cases of benign ocular tumors (68. 7%), and 158 cases of malignancy (31. 3%). Papillomas was the most common type of the benign with 83 cases (16. 5%), followed by a variety of inflammatory cysts and lesions with 69 cases ( 13. 7%) and 64 cases (12-7%) respectively. Among malignant tumors cases, eyelid basal cell carcinoma originated from epithelial was the most common with 72 cases (14. 3%), followed by skin appendages sources malignant tumors with 39 cases (7. 7%). Concerning the location of ocular tumors, there were 282 cases of eyelid tumor (56. 0%) occupied the first position followed by conjunctival tumor with 157 cases (31. 2%). CONCLUSION: The prevalence and type of primary ocular tumor in elderly people are significant differences from the general population and children's, and the proportion of malignant tumors tended to increase along with the increase of age.
ABSTRACT
PURPOSE: To report a case of subretinal hematoma secondary to polypoidal choroidal vasculopathy (PCV) misunderstood as a subretinal mass. CASE SUMMARY: A 73-year-old man with no specific medical history visited our clinic with decreased vision in the right eye. Slit-lamp examination revealed no specific findings for the anterior segment of the right eye. Upon fundus examination, an elevated macular lesion with some subretinal hemorrhages was observed, and a subretinal mass lesion was found on ultrasonography. After performing fluorescein angiography, indocyanine green angiography, and magnetic resonance imaging, we presumed that this lesion was a subretinal hematoma or ocular tumor and recommended observation. One month later, the subretinal mass had decreased in size. One year later, PCV with large retinal pigment epithelial detachment (RPED) was observed. After the intravitreal bevacizumab injection, RPED and macular edema were improved. CONCLUSIONS: We confirmed PCV with a subretinal hematoma and large RPED which seemed to be a subretinal mass and was difficult to differentiate from ocular tumors.
Subject(s)
Aged , Humans , Angiography , Antibodies, Monoclonal, Humanized , Choroid , Eye , Fluorescein Angiography , Hematoma , Hemorrhage , Indocyanine Green , Macular Edema , Magnetic Resonance Imaging , Retinal Detachment , Vision, Ocular , BevacizumabABSTRACT
Objective To observe the classification,clinical and pathological features of ciliary body tumors. Methods The clinical and pathological data of 11 cases of primary ciliary body tumors were analysed retrospectively. Results By pathological examination,the tumors of these cases were devided into malignant melanoma (2 cases), benign melanocytoma (3 cases),leiomyoma (2 cases), and angio- leiomyoma, neurilemoma, non-special granuloma and medulloepithelioma (1 case respectively). Both of the benign and malignant tumors of ciliary body tended to grow and enlarge progressively. The cardinal clinical manifestations of this series of 11 cases were as follows: elevation of intraocular pressure in 7, local scleral vascular dilatation in 5, secondary exudative retinal detachment in 5,and the signs of anterior uveitis in the early stage of tumor growth in 4. Conclusion The histopathological types of cilliary tumors are manifold,and the tumors are prone to enlarge progressively in developement either in benign or malignant ones, so that the rates of clinical misdiagnosis are relatively high.