Suppressive Effects of Kambaku-taiso-to on the Yawning Induced by Dopaminergic Agonist in Rats / 日本東洋医学雑誌

The present experiments were performed to investigate the potential role of Kambaku taiso-to (Gan mai da zao tang) in modifying the occurrence of yawning in rats. Subcutaneous injection of talipexole, a selective dopamine D-2 receptor agonist, at 5-100μg/kg, elicits yawning behavior for over one hour, the maximal effect being observed at a dose of 25μg/kg. Kambaku-taiso-to significantly suppressed the incidence of yawning induced by talipexole. These results suggest that Kambaku-taiso-to exerts a suppressive effect on the incidence of yawning.