Desordens hiperostóticas em American Bully / Hiperostotic disorders in american bully

O complexo de desordens hiperostóticas é uma condição rara e autolimitante, que tem as mesmas características histopatológicas, que cursa com proliferação óssea de caráter não neoplásico. Acomete cães jovens de raças distintas, com variabilidade quanto ao tipo de proliferação óssea e quanto aos ossos acometidos. O complexo é composto pela osteopatia craniomandibular, hiperostose da calota craniana e osteodistrofia hipertrófica. Podendo estar presente nos ossos da calota craniana, mandíbulas, coluna cervical e esqueleto apendicular. O presente relato, descreveu o quadro de uma cadela, da raça American Bully, não castrada, três meses de idade, que foi atendida com queixa de aumento de volume doloroso das mandíbulas, hiporexia e sialorreia há 15 dias, apresentando ao exame físico, amplitude de movimento diminuída e sensibilidade dolorosa da articulação temporomandibular, espessamento firme bilateral do crânio em região de fossa temporal, espessamento palpável de consistência firme das mandíbulas e crepitação respiratória. Após avaliação clínica e realização de exames complementares, chegou-se ao diagnóstico presuntivo, de complexo de desordens hiperostóticas. Foi instituído como conduta terapêutica o suporte analgésico, sendo eficaz para a manutenção das necessidades fisiológicas até a paciente alcançar a fase adulta. O prognóstico para esta paciente foi considerado bom, uma vez que não havia indícios de anquilose da articulação temporomandibular e/ou manifestações neurológicas.

The complex of hyperostotic disorders is a rare and self-limiting condition, which has the same histophatological characteristics, which courses with non-neoplastic bone proliferations. It affects young dogs of different breeds, with variability the bones affected. The complex is composed of craniomandibular osteopathy, calvarial hyperostotic syndrome and hypertrophic osteodystrophy. It may be present in the bones of the skullcap, jaws, cervical spine and appendicular skeleton. The present report describes the condition of a female dog, American Bully breed, entire, three months old, with a complaint of painful swelling of the jaws, hyporexia and drooling for 15 days, presenting on physical examination, reduced amplitude and pain of the temporomandibular joint, bilateral firm thickening of the skull in the temporal fossa region, palpable firm-consistent thickening of the mandibles and respiratory crackle. After clinical evaluation and complementary tests, a presumptive diagnosis of hyperostotic disorders complex was reached. It was instituted pain management as a treatment, being effective for the maintenance of physiological needs until the patient reaches the adulthood. The prognosis for this patient was considered good, since there was no evidence of temporomandibular joint ankylosis and/or neurological manifestations.

Research Progress on Relationship Between Intestinal Flora and Osteoporosis and Regulation of Traditional Chinese Medicine： A Review / 中国实验方剂学杂志

With the gradual aggravation of aging in China， the prevalence of osteoporosis is increasing year by year. Osteoporosis has become a major public health problem threatening the health of middle-aged and elderly people， especially middle-aged and elderly women. There are many predisposing factors and complex pathogenesis of osteoporosis. The interpretation of osteoporosis has been the focus of clinical research in recent years. How to prevent and treat osteoporosis more effectively has also become a major problem faced by researchers. In recent years， the balance and homeostasis of calcium and phosphorus regulated by intestinal absorption， renal excretion and bone have become one of the hot topics， and the balance and homeostasis of calcium and phosphorus in vivo are the key to normal bone homeostasis. At the same time， as a complex microbial community living in the gastrointestinal tract， intestinal flora can produce a variety of regulators affecting metabolism. It has been widely confirmed that it acts on the body indirectly or directly， in multiple ways and targets to prevent and treat osteoporosis. Therefore， further exploring the role and mechanism of intestine kidney bone axis in osteoporosis plays a far-reaching significance for the prevention and treatment of osteoporosis. In recent years， scholars have made a lot of exploration on the prevention and treatment of osteoporosis with traditional Chinese medicine （TCM）， and found that TCM can intervene the expression of intestinal flora and play the effect of prevention and treatment of osteoporosis. Based on the "intestine kidney bone axis"， this paper briefly discusses the integrated traditional Chinese and western medicine of kidney and osteoporosis， intestine and osteoporosis， intestine kidney axis， the treatment of kidney from intestine， intestine and osteoporosis， and the application of TCM in regulating intestinal flora in osteoporosis， in order to provide new ideas for the prevention and treatment of osteoporosis.

Research Progress on Relationship Between Intestinal Flora and Osteoporosis and Regulation of Traditional Chinese Medicine： A Review / 中国实验方剂学杂志

With the gradual aggravation of aging in China， the prevalence of osteoporosis is increasing year by year. Osteoporosis has become a major public health problem threatening the health of middle-aged and elderly people， especially middle-aged and elderly women. There are many predisposing factors and complex pathogenesis of osteoporosis. The interpretation of osteoporosis has been the focus of clinical research in recent years. How to prevent and treat osteoporosis more effectively has also become a major problem faced by researchers. In recent years， the balance and homeostasis of calcium and phosphorus regulated by intestinal absorption， renal excretion and bone have become one of the hot topics， and the balance and homeostasis of calcium and phosphorus in vivo are the key to normal bone homeostasis. At the same time， as a complex microbial community living in the gastrointestinal tract， intestinal flora can produce a variety of regulators affecting metabolism. It has been widely confirmed that it acts on the body indirectly or directly， in multiple ways and targets to prevent and treat osteoporosis. Therefore， further exploring the role and mechanism of intestine kidney bone axis in osteoporosis plays a far-reaching significance for the prevention and treatment of osteoporosis. In recent years， scholars have made a lot of exploration on the prevention and treatment of osteoporosis with traditional Chinese medicine （TCM）， and found that TCM can intervene the expression of intestinal flora and play the effect of prevention and treatment of osteoporosis. Based on the "intestine kidney bone axis"， this paper briefly discusses the integrated traditional Chinese and western medicine of kidney and osteoporosis， intestine and osteoporosis， intestine kidney axis， the treatment of kidney from intestine， intestine and osteoporosis， and the application of TCM in regulating intestinal flora in osteoporosis， in order to provide new ideas for the prevention and treatment of osteoporosis.

Resultados de una cohorte de pacientes tratados con osteopatía en un hospital polivalente / Results of a cohort of patients treated with osteopathy in a polivalent hospital

Introducción: la osteopatía aborda al paciente de manera global y aplica técnicas de tratamiento manual. Se realizó una evaluación retrospectiva sobre 447 pacientes para conocer los resultados del tratamiento del dolor lumbar y cervical. Material y métodos: fueron incluidos en este estudio 447 pacientes con diagnóstico de lumbalgia y cervicalgia (77,4% de sexo femenino). Los pacientes atendidos ya habían realizado tratamientos convencionales sin haber conseguido resultados satisfactorios. Se evaluó a los pacientes con la escala de valor numérico de dolor (EVN), y los puntajes (scores) de Oswestry (ODI) y el índice de discapacidad de la región cervical (NDI). Los 4 osteópatas intervinientes son profesionales certificados en esta disciplina. Resultados: el 42,8% de los pacientes fueron derivados por el Servicio de Traumatología y el 41,3% por el Servicio de Medicina Familiar. El 34,2% tuvieron diagnóstico de dolor lumbar y al 20,81% se le diagnosticó dolor cervical. Tanto en la valoración del dolor como en los scores utilizados se encontraron diferencias estadísticamente significativas entre la primera y la última sesión. Discusión: en pacientes con diagnóstico de lumbalgia y cervicalgia que no habían obtenido resultados satisfactorios con tratamientos convencionales previos, el tratamiento osteopático derivó en mejoras significativas en todos los parámetros estudiados. (AU)

Introduction: osteopathy addresses the patient globally and applies manual treatment techniques. A retrospective evaluation was carried out on 447 patients to know the results of the treatment of lumbar and cervical pain. Material and methods: 447 patients with a diagnosis of low back pain and cervical pain (77.4% female) were included in this study. The patients already had undergone conventional treatments without having achieved satisfactory results. The patients were evaluated with the numerical value of pain scale (VNS), and Oswestry scores (ODI) and the index of disability of the cervical region (NDI). The 4 intervening osteopaths are certified professionals in this discipline. Results: 42.8% of the patients were referred by the Traumatology Service and 41.3% by the Family Medicine Service. 34.2% had a diagnosis of lumbar pain and 20.8% were diagnosed with neck pain. Statistically significant differences were found between the first and last sessions in both the pain assessment and the scores used. Discussion: in patients with low back pain and neck pain who had not obtained satisfactory results with previous conventional treatments, osteopathic treatment resulted in significant improvements in all the parameters evaluated. (AU)

Mechanism of Modified Liuwei Dihuangtang in Bone Protection of CKD-MBD Model Rats： An Exploration Based on Klotho-FGF23 Axis / 中国实验方剂学杂志

Objective:To observe the effects of modified Liuwei Dihuangtang on serum fibroblast growth factor 23 （FGF23）， full-length intact parathyroid hormone （iPTH）， and 1，25-dihydroxyvitamin D₃［1，25（OH）₂D₃］ levels and Klotho and FGF23 protein expression in renal and bone tissues of rats exposed to high phosphorus combined with adenine， so as to explore the mechanism of modified Liuwei Dihuangtang against renal osteopathy. Method:One hundred and thirty healthy adult SD rats were randomly divided into five groups， namely normal group（<italic>n</italic>=10），high phosphorus group（<italic>n</italic>=30），model group（<italic>n</italic>=30），modified Liuwei Dihuangtang group（<italic>n</italic>=30） ， and calcitriol group（<italic>n</italic>=30），and rats in each group were further classified based on three time points， namely 8，10， and 12 weeks. Rats in the normal group were fed with normal diet， the ones in the high phosphorus group with high phosphorus diet， and those in the other groups with adenine and high phosphorus diet for inducing renal osteopathy. Rats in the normal group，high phosphorus group， and model group were intragastrically administered with distilled water （10 mL·kg^-1·d^-1），the ones in the modified Liuwei Dihuangtang group with modified Liuwei Dihuangtang （2.556 g·kg^-1·d^-1） ， and those in the calcitriol group with calcitriol （0.09 μg·kg^-1·d^-1）. Result:Compared with the normal group and high phosphorus group at the weeks of 8，10 and 12，the model group displayed significantly elevated blood urea nitrogen（BUN），serum creatinine（SCr），serum phosphorus，iPTH，FGF23，renal interstitial fibrosis score， and FGF23 expression in renal and bone tissues， but lowered serum calcium and 1，25（OH）₂D₃ and Klotho protein expression in renal and bone tissues（<italic>P</italic><0.05 ，<italic>P</italic><0.01）. Compared with the model group at the weeks of 8，10 and 12， the modified Liuwei Dihuangtang and calcitriol both significantly decreased the serum BUN，SCr，serum phosphorus，iPTH， FGF23， tubulointerstitial semi-quantitative score， and FGF23 expression in renal and bone tissues， while increased the serum calcium，1，25（OH）₂D₃， and Klotho protein expression in renal and bone tissues （<italic>P</italic><0.05，<italic>P</italic><0.01）. There was no significant difference in the above-mentioned indexes between the modified Liuwei Dihuangtang group and the calcitriol group at the same time point. Conclusion:Klotho-FGF23 axis is probably involved in renal osteopathy. The modified Liuwei Dihuangtang effectively improves renal function，alleviates pathological changes in renal and bone tissues，and regulates calcium and phosphorus metabolism to protect the bone， which is related to its regulation of Klotho-FGF23 axis.

Mongolian osteopathy in the treatment of ulna-radius fractures: Finite element analysis of mechanical principle / 中国组织工程研究

BACKGROUND: Mongolian osteopathy is famous for the complicated manipulation and theoretical complexity. Combined with the finite element model of ulna-radius fractures, the analysis on the manipulation of osteopathy has not been reported at home and abroad. OBJECTIVE: To simulate the force of various ulna-radius fractures and establish the model of ulna-radius fractures, to analyze the effect, and to analyze the manipulation mechanism of Mongolian osteopathy on the corresponding fractures. METHODS: One 35-year-old volunteer was selected to obtain the CT image data of the right forelimb after signed the informed consent. The geometric model of the radius and ulna was established based on the parameters of bone tissue. The material mesh was divided, and the load parameters were assigned for analysis and calculation. Based on the common causes of Colles and Smith fractures, the osteopathy manipulation was evaluated by combined with “force to force” of Mongolian osteopathy. RESULTS AND CONCLUSION: (1) The stress distribution of the model of ulna-radius fractures is highly consistent with previous studies of the forearm. The mechanical models of Colles and Smith fractures were obtained in the direction of stress. After adjusting the mechanical parameters of bone, the fracture models of four different ages could be simulated. (2) These results indicate that the finite fracture model is feasible. Meta-analysis could simulate the ulna-radius fractures, and provide a manual reference for treating ulna-radius fractures with “force-to-force” theory in Mongolian osteopathy.

Involvement and significance of large transmembrane protein piezo1 in orthopedic related diseases / 中国组织工程研究

BACKGROUND: Recent studies found that mesenchymal stem cells, osteoblasts and osteoclasts, cartilage cells, nucleus pulposus cells, and osteosarcoma cells can receive mechanical stimulation from extracellular environment through Piezo1 protein so as to activate cell signal transduction pathways, affecting cell proliferation, differentiation, migration and apoptosis, which determines physiological and pathological processes of physiological structure of bone, joint degeneration, and fracture healing. OBJECTIVE: To review Piezo1 related to osteoporosis and degenerative osteoarthropathy, summarize the latest advances by reviewing the latest discovery of Piezo1 in other orthopedic diseases, and provide ideas for novel treatment strategies for orthopedic related diseases. METHODS: A computer search was conducted on the literatures related to the research progress of Piezo1 in orthopedic diseases in CNKI and PubMed from inception to January 2020. The Chinese keywords were “mechanically sensitive ion channel proteins, osteoporosis, degenerative osteoarthropathy, orthopedic diseases”, and the English keywords were “Piezo1, osteoporosis, degenerative osteoarthropathy, orthopedic diseases”. A full web search was conducted, and finally 60 literatures were included for review and discussion. RESULTS AND CONCLUSION: (1) Piezo1 can release biological signals and regulate osteoclast activity during the development of osteoporosis by directly detecting the mechanical load in osteoblastic lineage cells. (2) In the progression of degenerative osteoarthropathy, Piezo1 on the cartilage cell membrane was able to effectively recognize stimuli of different strengths and types of external mechanical stress and eventually induce chondrocyte apoptosis. (3) In bone metabolic diseases, degenerative arthritis of joints and other orthopedic diseases, Piezo1 is involved in the pathological process of the disease. The emergence of Piezo1 provides a more specific molecular basis for the application of mechanical stimulation in orthopedics, opens a new thinking and perspective, and also lays a “hint” for the future dual drug administration and precision medicine.

Chronic multifocal osteomyelitis: A case report and literature review / 北京大学学报(医学版)

A case of chronic multifocal osteomyelitis was described in terms of its clinical manifestations, serological and imaging examinations, diagnostic criteria, treatment options, and follow-up evaluation after discharge. The pathogenesis, diagnosis, differential diagnosis and treatment of chronic multifocal osteomyelitis were reviewed, and the characteristics of autoinflammatory osteopathy were reviewed. The patient with onset from youth had developed severe skin lesions, progressive arthralgia and rachialgia. The clinical manifestation and the auxiliary examination of the patient accorded with the diagnosis of chronic multifocal osteomyelitis. After poor anti-inflammatory and analgesic effects, the switch to tumor necrosis factor alpha (TNF-α) inhibitor resulted in pain relief, normalization of inflammation indexes, and significant improvement in rash and imaging examination. Chronic recurrent multifocal osteomyelitis was a kind of autoinflammatory bone disease of multiple genes in disease with low incidence, unknown mechanism and unified diagnostic criteria. It was also known as chronic nonbacterial osteomyelitis, which was a rare, noninfectious inflammatory disorder that caused multifocallytic bone lesions characterized by periodic exacerbations and remissions. The exact pathophysiology or mechanism of the sterile bone inflammation was poorly understood, although chronic nonbacterial osteomyelitis was probably an osteoclast-mediated disease. In addition, an imbalance between pro- and anti-inflammatory cytokines was suspected to play a role. The available data so far pointed to the interplay among genetics, environmental, and immunologic factors as the causes of chronic nonbacterial osteomyelitis. Infectious etiology did not seem to play a crucial role in the pathogenesis of chronic nonbacterial osteomyelitis. It was often confused with metabolic bone disease, infection, tumor and other diseases. Its clinical manifestations were bone pain, fever, rash, fracture and so on. Laboratory examination showed significant increase in inflammatory markers. Radiographic examination revealed osteolytic or sclerosing changes. Magnetic resonance imaging was very useful for identifying bone lesions and tissue edema and was more accurate than bone emission computed tomography (ECT). Most of the patients begin to use non-steroidal anti-inflammatory drugs (NSAIDs) for treatment, but they are prone to relapse and new lesions appear. Other treatment options can be selected, including glucocorticoids, TNF-α inhibitors, bisphosphonates, methotrexate and other disease-modifying anti-rheumatic drugs (DMARDs). Early diagnosis and treatment can prevent and reduce complications and improve prognosis.

Australian osteopathic practitioners' perceptions of the clinical relevance of anatomy / Percepciones de los practicantes de osteopatía australianos de la relevancia clínica de la anatomía

SUMMARY: Anatomy is a foundational discipline in the training of health care professionals. However, there is a paucity of literature on the relative importance of anatomy, especially in relation to the other biomedical sciences and clinical domains, in preparing osteopathic practitioners for clinical practice. This study aimed to examine Australian osteopathic practitioners' perceptions of the relative importance of anatomy in their professional training and clinical practice, especially in relation to other biomedical sciences and clinical domains within osteopathic curricula. The study also examined the perceived importance of the sub-disciplines of anatomy to professional practice. A questionnaire-based survey was carried out among Australian osteopathic practitioners at several national meetings in 2014 and 2015. Using a five-point Likert scale, all respondents were asked to rate the relevance of the following thirteen disciplines and subdisciplines to clinical practice: biomechanics, biochemistry, embryology, histology, gross anatomy, microbiology, neuroanatomy, neurology, pathology, pharmacology, physical examination, physiology and radiology. Out of 175 practitioners surveyed, 169 responded (i.e., 96.6 % response rate). Two of the sub-disciplines of anatomy were among the highest rated, with 98.2 % perceiving gross anatomy as "very important" while neuroanatomy being rated as "very important" by 84.6 % and "quite important" by 14.2 %. Similar high rating was also given to biomechanics and physical examination while the other two sub-disciplines, embryology and histology received lower ratings. No significant difference in ratings were identified with regard to participants' year and place of graduation. However, there was an association between gender and rating on Pathology and Pharmacology respectively, as well as age effects on the ratings of several sub-disciplines. These findings are generally consistent with the results from similar surveys carried out on the clinical importance of anatomy in other medical and allied health professionals in different countries. Overall, osteopathic practitioners have a positive perception of the relevance of anatomy, particularly gross and neuroanatomy, to clinical practice, and this should be taken into account when developing osteopathic curricula.

RESUMEN: La anatomía es una disciplina fundamental en la formación de profesionales de la salud. Sin embargo, hay poca literatura sobre la importancia relativa de la anatomía, especialmente en relación con las otras ciencias biomédicas y los dominios clínicos, en la preparación de profesionales de la osteopatía para la práctica clínica. Este estudio tuvo como objetivo examinar las percepciones de los médicos osteopáticos australianos sobre la importancia relativa de la anatomía en su formación profesional y práctica clínica, especialmente en relación con otras ciencias biomédicas y dominios clínicos dentro de los currículos osteopáticos. El estudio también examinó la importancia percibida de las subdisciplinas de la anatomía para la práctica profesional. Se realizó una encuesta basada en un cuestionario entre los profesionales osteopáticos australianos en varias reuniones nacionales en 2014 y 2015. Utilizando una escala Likert de cinco puntos, se pidió a todos los encuestados que calificaran la relevancia de las siguientes trece disciplinas y subdisciplinas para la práctica clínica: Biomecánica, bioquímica, embriología, histología, anatomía macroscópica, microbiología, neuroanatomía, neurología, patología, farmacología, exploración física, fisiología y radiología. De los 175 practicantes encuestados, 169 respondieron (es decir, una tasa de respuesta del 96,6 %). Dos de las subdisciplinas de la anatomía estaban entre las mejor calificadas, con un 98,2 % que percibían la anatomía general como "muy importante", mientras que la neuroanatomía se calificaba como "muy importante" en un 84,6 % y "muy importante" en un 14,2 %. También se dio una calificación alta similar a la biomecánica y el examen físico, mientras que las otras dos subdisciplinas, embriología e histología recibieron calificaciones más bajas. No se identificaron diferencias significativas en las calificaciones con respecto al año de los participantes y el lugar de graduación. Sin embargo, hubo una asociación entre el sexo y la calificación en Patología y Farmacología respectivamente, así como los efectos de la edad en las calificaciones de varias subdisciplinas. Estos hallazgos son generalmente consistentes con los resultados de encuestas similares realizadas sobre la importancia clínica de la anatomía, en otros profesionales de la salud médicos y afines en diferentes países. En general, los profesionales de la osteopatía tienen una percepción positiva de la relevancia de la anatomía, en particular la neuroanatomía general y la neuroanatomía, para la práctica clínica, lo que se debe tener en cuenta al desarrollar los currículos osteopáticos.

The efficacy of motion control technique based on mobility test in rehabilitation of patients with physiologi-cal sacroiliac joint dysfunction / 实用医学杂志

Objective To explore the short-term efficacy of individualized motion control training for the patients with physiological sacroiliac joint dysfunction. Methods 58 patients were diagnosed as sacroiliac joint dysfunction by standing and sitting stoop test and single leg test. All the patients were randomly divided into two groups. Rotation of the iliac bone was adjusted by muscle energy technique and impact technique in all the patients. The study group received additional exercise control training including local muscle drafting,flexibility and stability. The short-term efficacy was observed. Results VAS and ODI in the two groups were improved significantly after treatment,and there was significant difference between the two groups before treatment(P < 0.01). Three weeks after treatment,the VAS score and ODI in the control group increased,while those in the study group did not change significantly. There was a significant difference in the continuous efficacy of treatment between the two groups(P < 0.05). Conclusions Motion control training based on manipulative exercise test evaluation has a better continuous efficacy for patients with no-specific low back pain and sacroiliac joint dysfunction. It is worth clinically popularizing.

A efetividade do tratamento osteopático na constipação intestinal: uma revisão sistemática / Effectiveness of the ostheopatic treatment in intestinal constipation: a systematic review

Introdução: a constipação intestinal é considerada uma doença funcional do intestino, caracterizada por uma desordem da motilidade gastrointestinal e por evacuações difíceis ou diminuídas. O tratamento e a prevenção devem ser individualizados, considerando as orientações comportamentais, além da possível intervenção farmacológica ou de terapias complementares como a osteopatia. Objetivos: revisar a literatura sobre os efeitos do tratamento osteopático na constipação intestinal. Metodologia: a pesquisa da literatura foi realizada nas bases de dados eletrônicas Portal CAPES, Bireme, Cochrane Library, Lilacs, Medline, PubMed e Scielo. Os 112 estudos utilizados nesta pesquisa seguiram os seguintes critérios de inclusão: publicações no período de 1989 a 2017; escritos em português, inglês e espanhol; artigos apresentados na íntegra, sem restrições sobre o tipo de estudo ou amostra. Resultados: a abordagem osteopática aplicada no tratamento da constipação tem como objetivo a melhora do funcionamento do intestino, influenciando o tônus do músculo liso e a mobilidade visceral, melhorando a função gastrointestinal e, indiretamente, normalizando o suprimento nervoso autossômico para a víscera. A fáscia é formada por uma matriz intracelular tridimensional de contiguidade, rica em mecanorreceptores, envolvendo e protegendo os tecidos e órgãos do corpo. Assim, resultados obtidos após a realização de técnicas osteopáticas, possivelmente, são compreendidos pelas propriedades mecânicas, autonômicas e neuromusculares. Conclusão: a osteopatia é um tratamento complementar para a constipação intestinal, melhorando os sintomas, reduzindo a gravidade dos quadros, diminuindo o tempo do trânsito colônico, aumentando a motilidade intestinal e a qualidade de vida dos pacientes.

Introduction: the intestinal constipation is considered a functional bowel disease, characterized by a gastrointestinal motility disorder and difficult or reduced evacuation. The treatment and prevention must be individualized, taking into consideration the behavioral orientation, besides a possible pharmacological intervention or complementary therapies such as osteopathy. Objective: review the literature on the effects of osteopathic treatment in intestinal constipation. Methodology: the research on literature was done using database of Portal CAPES, Bireme, Cochrane Library, Lilacs, Medline, PubMed and Scielo. The 112 studies used in this research followed these criteria of inclusion: publications from 1989 to 2017, in Portuguese, English and Spanish; articles presented in full, with no restrictions about the type of study or sample. Results: the osteopathic approach applied in the constipation treatment aims at a better functioning of the intestine, influencing the smooth muscle tonus and visceral mobility, thus improving the gastrointestinal function and indirectly normalizing the autosomal nervous supply for the viscera. A three-dimensional intracellular matrix forms the fascia in contiguity, which is abundant in mechanoreceptors, covering and protecting the tissues and organs in the body. Therefore, the results obtained after performing the osteopathic techniques are possibly understood by the mechanical, autonomic and neuro- muscular proprieties. Conclusion: osteopathy is a complementary treatment for intestinal constipation, improving the symptoms, reducing the severity of the condition, decreasing the time of colon transit and increasing the intestinal motility as well as the patients quality of life.

Discussion on LI Dong-yuan's Theory of "Atrophic Debility of Bones" and TCM Clinical Syndrome of Renal Osteopathy / 中国中医药信息杂志

LI Dong-yuan discussed the pathogenesis and treatment of "atrophic debility of bones" in his writings. This article explained and summarized the pathogenesis of atrophic debility of bones in LI's works. LI held that the pathogenesis of atrophic debility of bones is divided into damp-heat, overabundant yin leading to yang hyperactivity, and overabundant yin leading to insufficient yang. Combined with clinical observation, this article considered that the LI's atrophic debility of bones is similar to renal osteopathy in terms of disease name, clinical manifestation and pathogenesis. Therefore it put forward to the treatment of renal osteodystrophy from LI's theory. The methods of treatment were invigorating splenic yang and dehumidify, moistening dryness and tonifying kidney, replenishing qi, purging yin fire, raising yang and lifting prolapsed zang-fu organs, and expeling wind and removing dampness.

Research progress in metabolic bone disease of prematurity / 临床儿科杂志

Metabolic bone disease of prematurity (MBDP) is an important chronic disease in the neonates. The metabolic abnormalities of calcium, phosphorus, vitamin D and others in premature can lead to decline of bone mineral content, decrease of trabecular bone quantity, thinning of cortical bone, etc., which can cause rickets in severe cases and even fracture. Low gestational age and low birth weight of premature are important risk factors for metabolic bone disease. The diagnosis relies on clinical features as well as laboratory, radiological and ultrasonographic examinations. The treatment includes reinforcement of the passive movement, supplementiation of the calcium, phosphorus and vitamin D, better prevention and so on. Early detection, early diagnosis, and early treatment can reduce the incidence of sequelae of metabolic bone disease, and reduce the long-term impact on premature infants.

Discussion on LI Dong-yuan's Theory of "Atrophic Debility of Bones" and TCM Clinical Syndrome of Renal Osteopathy / 中国中医药信息杂志

LI Dong-yuan discussed the pathogenesis and treatment of "atrophic debility of bones" in his writings. This article explained and summarized the pathogenesis of atrophic debility of bones in LI's works. LI held that the pathogenesis of atrophic debility of bones is divided into damp-heat, overabundant yin leading to yang hyperactivity, and overabundant yin leading to insufficient yang. Combined with clinical observation, this article considered that the LI's atrophic debility of bones is similar to renal osteopathy in terms of disease name, clinical manifestation and pathogenesis. Therefore it put forward to the treatment of renal osteodystrophy from LI's theory. The methods of treatment were invigorating splenic yang and dehumidify, moistening dryness and tonifying kidney, replenishing qi, purging yin fire, raising yang and lifting prolapsed zang-fu organs, and expeling wind and removing dampness.

Research progress in metabolic bone disease of prematurity / 临床儿科杂志

Metabolic bone disease of prematurity (MBDP) is an important chronic disease in the neonates. The metabolic abnormalities of calcium, phosphorus, vitamin D and others in premature can lead to decline of bone mineral content, decrease of trabecular bone quantity, thinning of cortical bone, etc., which can cause rickets in severe cases and even fracture. Low gestational age and low birth weight of premature are important risk factors for metabolic bone disease. The diagnosis relies on clinical features as well as laboratory, radiological and ultrasonographic examinations. The treatment includes reinforcement of the passive movement, supplementiation of the calcium, phosphorus and vitamin D, better prevention and so on. Early detection, early diagnosis, and early treatment can reduce the incidence of sequelae of metabolic bone disease, and reduce the long-term impact on premature infants.

Application and prospects of orthopedic robots / 军事医学

Orthopedic robotics is an emerging industry in the area of healthcare , mainly used for minimally invasive treatment and accurate treatment .It can provide accurate surgical navigation and planning .Orthopedic robots can be mainly used for articular surgery , osteopathy surgery , spine surgery and traumatic orthopedics .This paper outlines the development and characteristics of orthopedic robots at home and abroad , analyzes the developments of orthopedic robots by combining medical imaging technology with clinical feedback , and predicts the future of this field .

Efetividade do tratamento osteopático na qualidade de vida e na percepção dos sintomas de pacientes com doença de refluxo gastroesofágico refratária ao tratamento medicamentoso / Osteopathic treatment effectiveness in quality of life and perception of patients with symptoms of reflux disease refractory gastroesophageal treatment drug

A Doença do Refluxo Gastroesofágico (DRGE) é uma condição que se desenvolve quando o refluxo do conteúdo gastroduodenal provoca sintomas e/ou complicações esofágicos ou extra-esofágicos, afetando negativamente a qualidade de vida do indivíduo. A osteopatia evidencia uma relação entre a anatomofisiologia da região esôfago-cárdio-tuberositária com a DRGE, sugerindo também que a modalidade terapêutica baseada na osteopatia pode ajudar no alívio dos sintomas. Portanto, o objetivo deste estudo foi avaliar os efeitos do tratamento osteopático em indivíduos com diagnóstico de DGRE resistentes ao uso de medicamentos por meio dos questionários de qualidade de vida (HBQOL) e de percepção dos sintomas (QS-DRGE). Contou com uma amostra de 14 pacientes com diagnóstico de DRGE refratária. A metodologia se baseou, num primeiro momento, na aplicação dos questionários aos participantes. Posteriormente, o grupo amostral foi submetido ao diagnóstico e atamento osteopáticos. Foram realizados 12 atendimentos de 60 minutos para cada paciente, uma vez por semana, e finalmente aplicados novamente aos questionários. As respostas de cada questionário foram comparadas entre os momentos pré e pós-tratamento, utilizando-se o teste de Wilcoxon Signed Rank. A análise comparativa demonstrou diferença significativa na maioria das perguntas dos dois questionários, exceto pela primeira questão do questionário HBQOL e por três questões das onze que compõem o questionário QS-DRGE. Os resultados sugerem que o tratamento foi eficiente para os participantes e que o entendimento das regiões anatomicamente ligadas à DRGE e aos questionários QS-DRGE e HBQOL parecem ferramentas úteis que podem ajudar no estabelecimento de parâmetros para validar o tratamento osteopático. Apesar dos achados, não é possível generalizar os resultados.

The Gastroesophageal Reflux Disease (GERD) is a condition that develops when the reflux of gastroduodenaln contents causes symptoms and / or complications esophageal and extra-esophageal. It adversely affects the quality of life of the individual. Osteopathy emphasizes a relationship between anatomy and physiology of the cardio - esophageal region tuberositária with GERD, also suggesting that the therapeutic modality based on osteopathy can help in relieving the symptoms. Therefore, aim of this study was to evaluate the effects of osteopathic treatment for individuals diagnosed with DGRE, resistant to drug use, through on Quality of Life Questionnaire (HBQOL) and Perception of Symptoms (Gastroesophageal Reflux Disease Questionnaire). It involved a sample of 14 people with a diagnosis of GERD. After applied questionnaires to participants, the group was subjected to the osteopathic diagnosis and treatment. 12 visits were performed 60 minutes each, once a week, and finally re-applied questionnaires. The responses from each questionnaire were compared between pre ?and post- treatment using the Wilcoxon Signed Rank test. Except for the first question of the questionnaire HBQOL, comparative analysis showed significant difference in all questions of the two questionnaires. The results suggest that the treatment was effective for the participants and that the understanding of the anatomically related to GERD and questionnaires for gastroesophageal reflux disease and HBQOL seem useful tools that can help establish parameters to validate the osteopathic treatment. However, it is not possible to generalize these results.

General Osteopathic Treatment is Associated with Postural Changes.

Aim: To investigate whether standard general osteopathic treatment can influence the static configuration of the vertebral column or pelvis. Material and Methods: One hundred thirteen persons, 72 females and 41 males, either symptomfree volunteers or patients with mild idiopathic back pain, were investigated using the DIERS formetric® system, before and immediately after a single session of general osteopathic treatment. Variables of static assessment of the thoraco-lumbar vertebral column and of the pelvis were compared before and after treatment, using paired statistics. Results: There was no difference between observations in the healthy controls and the symptomatic patients. The sagittal imbalance decreased significantly (two sided student’s t-test: P=0.034), apical deviation diminished (one sided student’s t-test: P= 0.047) after treatment and lordotic apex position increased (one sided student’s t-test: P=0.028). Since such changes have not been observed in a previous trial of repeat measurements without treatment, the observations in the present study suggest an effect of treatment. This effect was, however, limited to persons with sagittal imbalance not exceeding the 62nd percentile. Conclusion: General osteopathic treatment is associated with reduced sagittal imbalance and apical deviation and increased lordotic apex position, but this effect is demonstrable only in persons whose sagittal imbalance ranks in the lower or median tertile.

Sequential Proximal Tibial Stress Fractures associated with Prolonged usage of Methotrexate and Corticosteroids: A Case Report

Stress fractures of the proximal tibia metaphysis are rare in the elderly. We present a case of a 65-year old male who developed sequential proximal tibia stress fractures associated with prolonged usage of methotrexate and prednisolone within a span of 18 months. Magnetic Resonance Imaging revealed an incomplete stress fracture involving the medial proximal tibial region. The patient was treated with stemmed total knee arthroplasty (TKA) bilaterally. Stress fractures should be considered in patients with atypical knee pain who have a history of methotrexate and prednisolone usage. TKA is an effective treatment in stress fractures of the proximal tibia.

The therapeutic effect and nursing experience of different linked modes in hemodialysis combined with hemoperfusion on renal osteopathy disease in maintenance hemodialysis patients / 中国实用护理杂志

Objective To explore the therapeutic effect and nursing points of different linked modes in hemodialysis combined with hemoperfusion on renal osteopathy disease in maintenance hemodialysis (MHD) patients.Methods Sixty-four MHD patients with renal osteopathy disease were enrolled in the study.They were divided into two groups by random digits table method:the front connection group and the back connection group with 32 cases each.Their clinical data,serum parameters and complications were recorded.The therapeutic effect of two groups were compared.Results The serum level of intact parathyroid hormone(iPTH) was (191.36 ± 53.96) ng/L in the front connection group,while (133.02 ± 38.63) ng/L in the back connection group,and there was significant difference,t=3.517,P＜0.05.The incidence of lower blood pressure and blood coagulation were 8.85％(51/576),6.94％(40/576) in the back connection group,while 14.93％(86/576),15.97％(92/576) in the front connection group,and there were significant differences,x2=10.149,23.136,P＜0.01.Conclusion The back linked mode in hemodialysis combined with hemoperfusion can obviously decrease iP:TH of MHD patients combined with renal osteopathy disease and has less complications,worth clinical promotion.