ABSTRACT
@#Introduction: The optimal level of total 25(OH)D in Malaysian postmenopausal women that is necessary to ameliorate the combined effects of decreased bone mineral and muscle mass, and increase in adiposity, as seen in osteosarcopenic obesity, is unknown. Given that these are common pathologies existing in bone, muscle and excess fat-related disorders, this study investigated the association between body composition, functional capacity and total 25(OH)D levels. Methods: This was a cross-sectional study involving 117 postmenopausal Malaysian women aged 50-88 years. Total 25(OH)D was analysed by chemiluminescent microparticle immunoassay CMIA on Siemens® platforms. Bone mineral was measured by broadband ultrasound attenuation. Functional performance was assessed using modified components of short physical performance battery test. Statistical analysis was performed using the Statistical Package for Social Sciences (SPSS Version 25.0). Results: Overall, 47% women were vitamin D deficient; 3% had none, 22% had one, 65% had two, and 10% had all three adverse body composition indicators (osteosarcopenic obesity). Individuals without any adverse body composition indicator had higher total 25(OH) D (74.7±7.0nmol/L, p=0.004) compared to all the other groups [1 (53.0±3.8nmol/L); 2 (48.7±1.9nmol/L) and 3 (58.3±5.4nmol/L)]. The single inflection point (ROC curve) for total 25(OH)D in predicting osteosarcopenic obesity was 58.9nmol/L. Conclusion: Higher vitamin D levels were associated with lower body fat, enhanced bone quality, and improved functional capacity. Maintaining vitamin D levels above >58.9nmol/L may protect Malaysian postmenopausal women against the combined pathologies of bone, muscle and excess fat.
ABSTRACT
BACKGROUND: Studies have shown that osteoporosis, sarcopenia and obesity are important factors affecting metabolic diseases such as fracture, hypertension and dyslipidemia. OBJECTIVE: To describe the prevalence and influencing factors of osteosarcopenic obesity and its effects on racture and dyslipidemia, and to explore the role of diet and exercise in preventing osteosarcopenic obesity, so as to provide theoretical basis for the prevention and treatment of osteosarcopenic obesity METHODS: The related articles Included In PubMed and WANFANG database published from 1990 to 2018 were searched using the following keywords: Osteosarcopenlc obesity, sarcopenlc obesity, osteoporosis, sarcopenla, obesity, fracture, dysllpldemla, osteosarcopenlc obesity syndrome. The language was limited to “English” or “Chinese.” A total of 71 articles were Included for analysis and discussion. RESULTS AND CONCLUSION: (1) The age, sex, nationality or race differences in prevalence of osteosarcopenlc obesity have been found. The diagnostic criteria of osteosarcopenlc obesity, not international standard, have been established in the United States, Europe, Asia and others continents or countries; (3) Osteosarcopenlc obesity is affected not only by living and eating habits, but also by genes, cytokines and metabolic hormones. (4) Osteosarcopenic obesity exerts greater impact on fracture and dyslipidemia compared with osteoporosis, sarcopenia and obesity alone.
ABSTRACT
The ageing process is accompanied by osteoporosis,sarcopenia and obesity,which are named as osteosarcopenic obesity(OSO)syndrome.It is a recently identified syndrome characterized by simultaneous presence of osteopenia/osteoporosis,sarcopenia and increased adiposity(obesity),with a potential interconnection within these diseases via common pathophysiology.OSO is harmful for the elderly's physical-mental health and living quality,especially for bone fracture.Therefore,we reviewed a research progress on the relationship between OSO and fractures in the elderly.