Effect of Phyllanthus Amarus on Haloperidol Induced Catalepsy in Experimental Animal Models.

Objectives: The aim of the study was to investigate the anticataleptic effect of Phyllanthus amarus ethanolic extract in Swiss albino mice. Methods: The ethanolic extract of leaves of Phyllanthus amarus [PAEE] at a dose of 100mg/kg/body weight was administered orally for ten days. On tenth day, one hour later Haloperidol [1 mg/ kg IP] was administered to induce catalepsy. Results: The results indicate that induction of catalepsy by Haloperidol in Swiss albino mice was significantly prevented by PAEE. Conclusions: The anticataleptic activity of Phyllanthus amarus can be due to its effect on brain neurotransmitters or due to antioxidant property.