ABSTRACT
Objective To study the effect of sufentanil combined with nalbuphine on patient-controlled intravenous analgesia (PCIA)management after cesarean section.Methods The obj ects of study included 150 primiparas who underwent cesarean section in our hospital from January 2016 to March 2017,aged 20-35 years,weighing 54-89 kg,ASA physical status Ⅰ or Ⅱ.The primiparas were randomly divided into three groups,50 in each group.Sufentanil group (group S):sufentanil 2 μg/kg+tropisetron 10 mg;Nalbuphine group (group N):nalbuphine 2 mg/kg+tropisetron 10 mg;Sufentanil combined with nalbuphine group (group SN):sufentanil 1 μg/kg+nalbuphine 1 mg/kg+tropisetron 10 mg.The VAS scores,Ramsay scores and the incidence of respiratory depression of pain (rest,coughing)and Ramsay sedation scores were observed at 1,3,6,9,12,24,36 h after the caesarean section.Actual pressing times of PCIA were further evaluated.Adverse reactions were ob-served,such as nausea and vomiting,respiratory depression.Results There was no statistical differ-ence in VAS scores,Ramsay scores and the incidence of respiratory depression of patients at rest a-mong the three groups.However,when coughing,the VAS scores in patients of group SN were sig-nificantly lower than those of groups S and N (P<0.05).The incidence of nausea and vomiting in group N and group SN was significantly lower than that in group S (P<0.05).The actual pressing times of PCIA were significantly less in group SN than those in group S and group N (P<0.05). Conclusion Sufentanil combined with nalbuphine can achieve satisfactory analgesic effect on PCIA management after cesarean section.
ABSTRACT
OBJECTIVE:To investigate the effects of preemptive analgesia of parecoxib-sodium for radical mastectomy of breast cancer. METHODS:A total of 60 female patients underwent selective radical mastectomy of breast cancer under general anes-thesia were randomly divided into observation group(40 cases)and control group(20 cases). 15 min before anesthesia induction, observation group was given intravenous injection of Parecoxib-sodium for injection 40 mg. Control group was given intravenous in-jection of 0.9% Sodium chloride injection 5 mL. The pain visual analogue scale(VAS),the frequency of patient controlled intrave-nous analgesia(PCA)and ADR were observed between 2 groups at different time points after surgery. RESULTS:VAS scores of observation group were significantly lower than those of control group 2,4,6,8 h after operation,and the frequency of PCA 0-4, 4-12,12-24,24-36 h after operation was significantly lower than control group,with statistical significance(P0.05). CONCLUSIONS:The preemptive analgesia of parecoxib-sodium can effectively reduce pain degree of patients with breast cancer after radical mastectomy,the frequency of PCA, and do not increase the occurrence of ADR.