Genetic polymorphism of interleukins 6 and 17 correlated with apical periodontitis: A Cross-sectional study

Abstract Interleukins 6 and 17 act in bone resorption in the presence of infections of endodontic origin for host defense. Genetic polymorphisms may be associated with increased bone loss, represented by areas of large periapical lesions. This study aimed to verify the frequency of interleukin 6 and 17 gene polymorphism in patients with asymptomatic apical periodontitis or chronic apical abscess and to verify the existence of correlations between periapical lesion area with age, gender, and presence of the polymorphism, in the studied population, in the state of Pernambuco. A population consisting of thirty diagnosed individuals was included. The area of the lesions was measured in mm². Genomic DNA was extracted and genotyping was performed by Polymerase Chain Reaction Restriction Fragment Length Polymorphism for interleukin 6 (rs 1800795) and interleukin 17 (rs 2275913). Fisher's exact, chi-square, and odds ratio tests were used. A logistic regression analysis was also performed using sex, age, and the presence of polymorphism as covariates, in addition to linear regression to test the relationship between age and lesion area. All tests used a significance level of 0.05% (p ≤0.05%). There was no statistical significance in the occurrence of large areas of periapical lesions correlated with age, sex, and diagnosis, nor in the distribution of alleles in the polymorphism of interleukins 6 and 17 in the studied groups. The frequency of homozygous and heterozygous polymorphism was high. The polymorphism of these interleukins is not correlated with the increase in the areas of asymptomatic periapical inflammatory lesions.

Resumo As interleucinas 6 e 17 atuam na reabsorção óssea na presença de infecções de oriegem endodôntica para defesa do hospedeiro. Polimorfismos genéticos podem estar associados ao aumento da perda óssea, representada por áreas de lesões periapicais grandes. O objetivo deste estudo foi verificar a frequência do polimorfismo dos genes interleucina 6 e 17 em pacientes com periodontite apical assintomática ou abscesso apical crônico e verificar a existência de correlações entre área de lesão periapical com idade, sexo e presença do polimorfismo, na população estudada, no estado de Pernambuco. Foi incluída uma população constituída por trinta indivíduos diagnosticados. A áreas da lesões foram medidas em mm². O DNA genômico foi extraído e a genotipagem realizada por Polimorfismo de Comprimento de Fragmento de Restrição de Reação em Cadeia da Polimerase para interleucina 6 (rs 1800795) e interleucina 17 (rs 2275913). Os testes exato de Fisher, qui-quadrado e odds ratio foram utilizados. Uma análise de regressão logística também foi realizada usando sexo, idade e presença de polimorfismo como covariável, além de regressão linear para testar a relação da idade e área da lesão. Todos os testes utilizaram um nível de significância de 0,05% (p ≤0.05%). Não houve significância estatística na ocorrência das áreas grandes de lesões periapicais correlacionadas com idade, sexo e diagnóstico nem nas distribuições de alelos no polimorfismo das interleucinas 6 e 17 nos grupos estudados. A frequência de polimorfismo homozigoto e heterozigoto foi alta. O polimorfismo dessas interleucinas não está correlacionado ao aumento das áreas das lesões inflamatórias periapicais assintomáticas.

Clinical Approach of Extensive Periapical Lesion with Periradicular Regenerative Surgery: A Case Report with 7 Year Follow Up

The aim of this study is to report a case of two maxillary incisors with chronic apical abscess and through-and-through lesion submitted to periradicular regenerative surgery, with clinical follow-ups and evaluation through cone-beam computerized tomography for 7 years. In the presentation, there was a persistent sinus tract in the palate and sensibility to touch at the apical region of the central and left lateral maxillary incisors. The initial tomography revealed the presence of an extensive radiolucent area in the apical third of the referred teeth, with loss of the buccal and palatal cortic es. For the treatment, a periradicular regenerative surgery was performed, an association of endodontic surgery with Guided Tissue Regeneration technique, using bovine bone xenograft and bioabsorbable membrane. The clinical and radiographic evaluations, including cone-beam computerized tomography, at seven years postoperatively, showed absence of symptomatology and sinus tract, probing depth within normal standards and apical bone neoformation.

El objetivo de este estudio fue reportar un caso de dos incisivos superiores con absceso apical crónico y lesión transversal sometidos a cirugía regenerativa perirradicular, con seguimiento clínico y evaluación mediante tomografía computarizada de haz cónico durante 7 años. En la presentación, había un trayecto sinusal persistente en el paladar y sensibilidad al tacto en la región apical de los incisivos maxilares laterales central y lateral izquierdo. La tomografía inicial reveló la presencia de una extensa zona radiolúcida en el tercio apical de los dientes referidos, con pérdida de las cortezas bucal y palatina. Para el tratamiento se realizó una cirugía regenerativa perirradicular, asociación de cirugía endodóntica con técnica de Regeneración Tisular Guiada, utilizando xenoinjerto óseo bovino y membrana bioabsorbible. Las evaluaciones clínicas y radiográficas, incluida la tomografía computarizada de haz cónico, a los siete años del posoperatorio, mostraron ausencia de sintomatología y tracto sinusal, profundidad de sondaje dentro de los estándares normales y neoformación ósea apical.

Absceso dentoalveolar agudo en escolares de Tuinucú / Acute dentoalveolar abscess in pupils from Tuinucú

RESUMEN Fundamento: Los abscesos dentoalveolares agudos constituyen causa frecuente de las visitas de los niños a la consulta estomatológica. Objetivo: Identificar los dientes afectados por absceso dentoalveolar agudo y sus factores de riesgo en escolares de en la Escuela Primaria Melanio Hernández de Tuinucú. Metodología: Se realizó un estudio descriptivo, transversal en la Escuela Primaria de Tuinucú en el período comprendido entre septiembre de 2020 y abril de 2021. Se seleccionaron 30 escolares de 2do grado con absceso dentoalveolar agudo. Se utilizaron métodos del nivel teórico, empírico y estadístico. Se estudiaron las variables: sexo, diente afectado y factores de riesgos del absceso dentoalveolar agudo. Resultados: El 53.3 % de los escolares presentó absceso dentoalveolar agudo en los primeros molares temporales y el 43.3 % en los segundos. El 97 % tiene desconocimiento del absceso alveolar agudo y el 70 % estuvo afectado por caries dental. Conclusiones: Los primeros y segundos molares temporales fueron los dientes con mayor afectación por absceso alveolar agudo, sobre todo los inferiores, con predominio de la caries dental y el desconocimiento sobre el absceso dentoalveolar agudo como principales factores de riesgo.

ABSTRACT Background: Acute dentoalveolar abscesses are a frequent cause for children to visit the dentist. Objective: To identify the teeth affected by acute dentoalveolar abscess and their risk factors in pupils at the Melanio Hernández Elementary School in Tuinucú. Methodology: A descriptive, cross-sectional study was conducted at the Primary School in Tuinucú from September 2020 to April 2021. 30 2nd grade pupils with acute dentoalveolar abscess were selected. Methods of the theoretical, empirical and statistical level were used. The variables studied were: sex, affected tooth and risk factors for acute dentoalveolar abscess. Results: 53.3 % of pupils presented acute dentoalveolar abscess in the first primary molars and 43.3 % in the second. 97 % are unconscious of the acute alveolar abscess and 70 % were affected by dental caries. Conclusions: The first and second primary molars were the teeth mostly affected by acute alveolar abscess, especially those lower part, with prevalence of dental caries and lack of knowledge about acute dentoalveolar abscess as the main risk factors.

Chronic inflammatory periapical diseases: a Brazilian multicenter study of 10, 381 cases and literature review

Abstract The aim of this study was to investigate the epidemiological and clinical characteristics of chronic inflammatory periapical diseases in different regions of Brazil and to compare with data from the literature. A multicenter study was carried out in four Brazilian referral centers in oral diagnosis. Histopathological records were reviewed, and all cases diagnosed microscopically as periapical granuloma, radicular cyst, and periapical abscess were included. Demographic and clinical data were collected. Descriptive statistics and Pearson's chi-square test were performed. A total of 10,381 cases of chronic inflammatory periapical diseases were found (13.8% of 74,931 archived specimens) over a period of 65 years. Radicular cysts were the most common lesion (59.9%). Women (56.1%) with a mean age of 37.01 years old (range 13 to 100 ± 14.42) and people of white skin color (59.2%) were the most affected individuals by chronic inflammatory periapical diseases. The lesions were generally asymptomatic (28.1%), located in the maxilla (60.1%), and posterior region (49.8%). The radicular cysts were larger when compared to periapical granulomas (p < 0.001). The disagreement between the clinical and histopathological diagnoses was higher when the final diagnosis was a periapical granuloma (p < 0.001). Chronic inflammatory periapical diseases continue to be common lesions affecting mainly adults. This should be a consequence of the burden of untreated caries in permanent teeth. Women are more affected and radicular cyst was the most common lesion.

Infecção cervicofacial grave de origem odontogênica: relato de caso / Severe cervicofacial infection of odontogenic origin: case report

Introdução: as infecções odontogênicas tem como principal origem a necrose pulpar com invasão bacteriana no tecido periapical e periodontal, podendo levar à formação de quadros de celulite e posteriormente de abscesso, além disso, possuem o potencial de disseminar-se pelos espaços faciais profundos e comprometer a vida do paciente. Complicações graves, decorrentes dos quadros de infecções odontogênicas, podem ocorrer, se o tratamento instituído não for adequado, como: trombose do seio cavernoso, abscesso cerebral, mediastinite e até óbito. Objetivo: discutir o manejo das infecções odontogênicas disseminados em espaços faciais profundos, através do relato de caso clínico. Caso clínico: paciente de 52 anos, portador de diabetes mellitus tipo 2, com infecção odontogênica, no exame clínico inicial apresentava trismo, disfonia, dispneia, disfagia, hiperemia e edema em lado esquerdo da face, envolvendo os espaços canino, bucal, submandibular e cervical além de unidades dentárias com foco infeccioso. Em exame de tomográfica computadorizada, observou-se desvio da via área, presença de um grande volume de gás e de lojas de infecção. Optou-se como tratamento a remoção dos focos dentários e drenagem intraoral foi realizada pela equipe da CTBMF com anestesia local e posteriormente drenagem sob anestesia geral, intubação com uso de fibroscopia pela equipe de cirurgia cabeça e pescoço. Considerações finais: as infecções odontogênicas que envolvem espaços faciais profundos devem ser tratadas com urgência e o tratamento de escolha dessa condição deve ser remoção imediata do foco infeccioso, exploração e drenagem rápida e agressiva dos espaços faciais envolvidos e associação com antimicrobianos de amplo espectro com características bactericidas.(AU)

Introduction: the main origin of odontogenic infections is pulp necrosis with bacterial invasion in the periapical and periodontal tissue, which may lead to the formation of cellulitis and later abscess, besides having the potential to spread to the deep facial spaces and compromise the patient's life. Severe complications from dental infections may occur if the treatment is not appropriate, such as cavernous sinus thrombosis, brain abscess, mediastinitis and even death. Objective: to discuss the management of disseminated odontogenic infections in deep facial spaces through a case report. Case report: a 52-year-old patient with type 2 diabetes mellitus, with odontogenic infection, presented at the initial clinical examination trismus, dysphonia, dysphagia, dysphagia, hyperemia and edema on the left side of the face involving the canine, buccal, submandibular and cervical spaces. of dental units with infectious focus. CT scan revealed deviation of the airway, presence of a large volume of gas and infection stores. The treatment was chosen to remove dental foci and intraoral drainage was performed by the CTBMF team under local anesthesia and subsequently under general anesthesia drainage, intubation with fibroscopy by the head and neck surgery team. Final considerations: odontogenic infections involving deep facial spaces should be treated urgently and the treatment of choice for this condition should be immediate removal of the infectious focus, rapid and aggressive exploration and drainage of the involved facial spaces and association with broad-spectrum antimicrobials with bactericidal characteristics.(AU)

The Therapeutic Protocols and Endodontic Management of Acute Apical Abscess in Adults: A systematic Review

Objective: The current review aims to compile all the up-to-date and available studies including imperative information concerning the therapeutic protocols and endodontic management available for the diagnosticated acute apical abscess cases. Material and methods: The electronic databases PubMed and Google Scholar were searched in this review using specific inclusion and exclusion criteria. The search was performed in December 2018 and updated in October 2019. Among 6328 studies, thirty-one studies satisfied the eligibility criteria and were included in the review to be analyzed. Results: The thirty-one studies showed the therapeutic Protocols and Endodontic Management of dentoalveolar abscesses in removing infections within the root canal system and their effect in periapical tissue healing. These studies investigated different aspects of an acute apical abscess, including endodontic management, antibiotic therapy, and therapeutic protocols. Conclusion: The compiled data observed that the decision for which treatment should be accomplished changes by patient manifestations when the exceptional acute apical abscess can show local and systemic causes, which can diversify the indicated therapy. At long last, a suitable finding is critical to characterize the patient’s best treatment approach and life support. When it improves the determination of the best treatment approach to manage to be used and avoid medicine aimless use, mainly antibiotics, and maximally decreasing malpractice or potentially superfluous methods.

Abscesso dentoalveolar crônico em paciente pediátrico com drenagem rara / Absceso dentoalveolar crónico en paciente pediátrico con drenaje raro / Chronic dentoalveolar abscess in a pediatric patient with rare drainage

RESUMO Introdução: As infecções do complexo maxillomandibular são corriqueiras na odontologia, podendo ser um quadro facilmente revertido, a depender da habilidade do profissional de diagnosticar e tratar precocemente, bem como da imunocompetência do paciente. Seu fator etiológico na grande maioria das vezes é de origem dentária, possuindo microbiota mista com presença de Streptococos e Peptostreptococos. Estas bactérias estão associadas ao processo de necrose pulpar e formação de abscesso dentoalveolar. Quando este quadro se desenvolve a partir dos molares inferiores, a disseminação ocorre normalmente pelo espaço vestíbulo bucal. No entanto, há casos que evadem o padrão, podendo um molar disseminar através dos espaços mastigador, mandibular, submandibular, sublingual e submentoniano. Objetivo: Relatar um caso de infecção odontogênica do dente 36, com disseminação atípica para o espaço submandibular em paciente pediátrico. Relato de caso clínico: Paciente do sexo feminino, 8 anos de idade, constou em seu histórico odonto-médico, junto a sua genitora, episódio de internamento para diagnóstico e tratamento da infecção em face. O diagnóstico de celulite foi determinado e a origem dentária descartada. Iniciou antibióticoterapia e após regressão teve alta. Após 9 meses apresentou reagudização do processo com disseminação para região submandibular. Através da história da doença atual, exame físico e radiográfico foi definido o diagnóstico de abscesso dentoalveolar crônico com disseminação e drenagem para o espaço submandibular, optando-se pela exodontia e antibióticoterapia. Conclusões: Faz-se importante o diagnóstico e tratamento precoce, afim de evitar a progressão para complicações mais severas, como a mediastinite e fasciíte necrosante(AU)

RESUMEN Introducción: Las infecciones del complejo maxilo-mandibular son comunes en la odontología, pudiendo ser un cuadro fácilmente revertido, que depende de la habilidad del profesional de diagnosticar y tratar precozmente, así como de la inmunocompetencia del paciente. Su factor etiológico en la gran mayoría de las veces es de origen dental, con microbiota mixta y presencia de Streptococos y Peptostreptococos. Estas bacterias están asociadas al proceso de necrosis pulpar y formación de absceso dentoalveolar. Cuando este cuadro se desarrolla a partir de los molares inferiores, la diseminación ocurre normalmente por el espacio vestíbulo bucal. Sin embargo, hay casos que evaden el estándar, pudiendo un molar diseminar a través de los espacios masticador, mandibular, submandibular, sublingual y submentoniano. Objetivo: Describir un caso de infección odontogénica proveniente de necrosis pulpar del diente 36, con diseminación atípica para el espacio submandibular en paciente pediátrico. Caso clínico: Paciente de sexo femenino, de 8 años, constó en su historia médica-dental, episodio de internamiento para diagnóstico y tratamiento de la infección en el rostro. Se determinó el diagnóstico de celulitis y tuvo el origen dental descartado. Se inició antibioticoterapia y se dio alta hospitalaria. Después de 9 meses presentó exacerbación del proceso con diseminación para región submandibular. A través de la historia de la enfermedad actual, examen físico y radiográfico se definió el diagnóstico de absceso dentoalveolar crónico con diseminación y drenaje para el espacio submandibular, y entonces fue posible optar por la exodoncia y antibioticoterapia. Conclusiones: Se hace importante el diagnóstico y tratamiento precoz, a fin de evitar la progresión para complicaciones más severas, como la mediastinitis y fasciitis necrosante(AU)

ABSTRACT Introduction: Infections of the maxillomandibular complex are common in dentistry and may be easily reversed, depending on the professional's ability to diagnose and treat promptly, as well as the patient's immunocompetence. In most cases their etiology is dental, i.e. a mixed microbiota with presence of Streptococci and Peptostreptococci. These bacteria are associated to the process of pulp necrosis and dentoalveolar abscess formation. When this condition develops from the lower molars, dissemination usually occurs through the buccal vestibular space. However, there are cases that do not follow this pattern, allowing a molar to spread through the buccal, mandibular, submandibular, sublingual and submental spaces. Objective: Report a case of odontogenic infection from pulp necrosis of the lower first molar (36) ​​with atypical dissemination to the submandibular space in a pediatric patient. Clinical case: Female 8-year-old patient with an episode of hospitalization for diagnosis and treatment of a facial infection, according to her medical / dental record. The infection was diagnosed as cellulitis and dental origin was discarded. Antibiotic therapy was started and the patient was discharged. After 9 months, the infection underwent a process of exacerbation with dissemination to the submandibular region. Analysis of the antecedents of the current condition, alongside physical and radiographic examination, led to the diagnosis of chronic dentoalveolar abscess with dissemination and drainage to the submandibular space, and the consequent indication of dental extraction and antibiotic therapy. Conclusions: Early diagnosis and treatment are vital to avoid progression to severer complications such as mediastinitis and necrotizing fasciitis(AU)

Consecuencias clínicas de caries dental no tratada en preescolares y escolares de instituciones educativas públicas / Clinical consequences of untreated dental caries in preschool and school children of public educational institutions

Objetivos: Evaluar la prevalencia y severidad de las consecuencias de la caries dental no tratada empleando el índice PUFA/pufa en preescolares y escolares de instituciones educativas públicas en una población urbano marginal del Callao. Material y métodos: El estudio fue descriptivo y observacional. Se empleó una base de datos generada que fue procesada con el programa Epi Info® y se exportó al programa estadístico IBM SPSS Statistics v. 19,0 (SPSS Inc.). Se realizó el análisis univariado y bivariado. Resultados: Se evaluaron 1085 niños entre 3 y 16 años. La mayor proporción fue del sexo masculino 557 (51,34%). La frecuencia del índice PUFA/pufa fue 25,71% y el promedio fue de 0,63 ± 1,48. El componente P+p representa el 24,70%, siendo las piezas deciduas las de mayor prevalencia. El grupo de 6-7 años y 8-10 años tuvieron la mayor frecuencia. El maxilar inferior fue el más afectado. Conclusiones: Las consecuencias clínicas de caries no tratada en la población estudiada son altamente frecuentes y severas.

Objectives: To evaluate the prevalence and severity of the consequences of untreated dental caries using the PUFA/pufa index in preschool and school children of public educational institutions in a marginal urban population of Callao. Material and methods: the study was descriptive and observational. A database was used and processed with the Epi Info® program and exported to the statistical program IBM SPSS Statistics v. 19.0 (SPSS Inc.). The univariate and bivariate analysis were performed. Results: 1085 children between 3 and 16 years old were evaluated. The highest proportion was male 557 (51.34%). The frequency of the PUFA/pufa index was 25.71% and the average was 0.63 ± 1.48. The P + p component represents 24.70%, the deciduous teeth was the most prevalent. The group of 6-7 and 8-10 years had the highest frequency. The lower jaw was the most affected. Conclusions: The clinical consequences of untreated caries in the studied population are highly frequent and severe.

Common pitfall of plastic surgeon for diagnosing cutaneous odontogenic sinus

Dental origins are a common cause of facial cutaneous sinus tracts. However, it can be easily overlooked or misdiagnosed if not suspected by a surgeon who is not familiar with dental origins. Cutaneous odontogenic sinuses are typically nodulocystic lesions with discharge and are most frequently located on the chin or jaw. This article presents two cases of unusual cutaneous odontogenic sinus presentations, as deep dimpling at the middle of the cheek. The patients were undergone surgical excision of sinus tract and dimpling immediate before and after treatment of causal teeth and the lesions resolved without recurrence. Surgeons should consider dental origins of facial dimpling lesions with discharge and provide appropriate treatment.

Comparison of two combinations of opioid and non-opioid analgesics for acute periradicular abscess: a randomized clinical trial

Abstract Acute periradicular abscess is a condition characterized by the formation and propagation of pus in the periapical tissues and generally associated with debilitating pain. Objective: The aim of this study was to compare the overall analgesic effectiveness of two combinations of opioid and non-opioid analgesics for acute periradicular abscess. Material and Methods: This study included 26 patients who sought emergency care in a Brazilian dental school. The patients were randomly divided into two groups: Co/Ac - oral prescription of codeine (30 mg) plus acetaminophen (500 mg), every 4 h, for 3 days or Tr/Ac - oral prescription of tramadol hydrochloride (37.5 mg) plus acetaminophen (500 mg) on the same schedule. Two factors were evaluated: (1) pain scores recorded by the patients in a pain diary 6, 12, 24, 48, and 72 h after treatment, using the Visual Analogue Scale; and (2) the occurrence of adverse effects. Results: In both groups, there was a reduction in pain scores over time. For the Co/Ac group, there was a significant reduction in the scores 12, 24, 48, and 72 hours after treatment (P<0.05). In the Tr/Ac group, the scores significantly decreased over time from time point 6 h (P<0.05). Comparing the pain at each time point, the groups were not significantly different (P>0.05), i.e., both treatments were effective in controlling pain caused by APA; however, the combination of Tr/Ac caused more adverse reactions as two patients had to stop using the medication. Conclusion: This study suggests that, considering both analgesic efficacy and safety, the combination of codeine and acetaminophen is more effective to control moderate to severe pain from acute periradicular abscesses.

Association Between Apical Periodontitis and TNF- alpha -308 G>A Gene Polymorphism: A Systematic Review and Meta-Analysis

Abstract Currently, investigations have focused on the identification of Single Nucleotide Polymorphisms (SNP) involved in host response and its ability to generate an immunity deficiency. The aim of this study was to perform a systematic review (SR) and meta-analysis to evaluate the association between TNF-α -308 G>A polymorphism and apical periodontitis (AP) phenotypes. A broad search for studies was conducted. The following databases were used: PubMed, Scopus, Web of Science, and VHL (Medline, SciELO, Ibecs, and Lilacs). The MeSH terms "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide" were used. MeSH synonyms, related terms, and free terms were included. Clinical investigations of individuals with different AP phenotypes in permanent teeth were selected. After application of the eligibility criteria, selected studies were qualified by assessing their methodological quality. A fixed effect model was used for the meta-analysis. The initial search identified 71 references. After excluding duplicate abstracts, 33 were selected. From these, two were eligible for quality assessment and were classified as being of moderate evidence. The included studies did not demonstrate association between AP and TNF-α -308 G>A SNP. However, the meta-analysis demonstrated an association between the genotype distribution and AP phenotype (OR= 0.49; confidence interval= 0.25, 0.96; p=0.04). The role of TNF-α -308 G>A SNP in AP phenotypes is debatable. Further studies are needed to confirm and understand the underlying mechanisms of the identified association.

Resumo Atualmente as investigações têm focado na identificação de Polimorfismos de Núcleo Único (SNP) envolvidos na resposta do hospedeiro e sua capacidade de gerar uma deficiência de imunidade. O objetivo deste estudo foi realizar uma revisão sistemática (RS) e uma meta-análise para avaliar a associação entre o polimorfismo do gene TNF-α (-308 G> A) e os fenótipos de periodontite apical (PA). Esta RS foi registrada na base de dados PROSPERO, CRD42016035688, e foi conduzida seguindo o método PRISMA. Foi realizada uma ampla pesquisa de estudos. Foram utilizadas as seguintes bases de dados: PubMed, Scopus, Web of Science e BVS (Medline, SciELO, Ibecs e Lilacs). Foram utilizados os seguintes descritores (MeSH) "Periapical Periodontitis," "Periapical Abscess," "Polymorphism, Genetic," and "Polymorphism, Single Nucleotide". Sinônimos, termos relacionados e termos livres foram incluídos. Foram selecionadas investigações clínicas de indivíduos com diferentes fenótipos de PA em dentes permanentes. Após a aplicação dos critérios de elegibilidade, os estudos selecionados foram classificados através da avaliação da qualidade metodológica. Foi utilizado um modelo de efeito fixo para a metanálise. A pesquisa inicial identificou 71 referências. Após a exclusão de resumos duplicados, 33 foram selecionados. Destes, dois eram elegíveis para a avaliação da qualidade e foram classificados como sendo de evidência moderada. Os estudos incluídos não demonstraram associação entre PA e o TNF-α-308 G>A. No entanto, a metanálise demonstrou associação entre a distribuição do genótipo e os fenótipos da PA (OR = 0,49, intervalo de confiança=0,25, 0,96; p=0,04). O papel do TNF-α-308 G>A em fenótipos da PA é discutível. São necessários mais estudos para confirmar e compreender os mecanismos subjacentes à associação identificada.

Chondroblastic osteosarcoma mimicking periapical abscess

Abstract Lesions of non-endodontic origin may mimic periapical abscess. Osteosarcoma is a rare malignant lesion. Case report The present report describes a case of chondroblastic osteosarcoma in the periapical region of teeth #29, #30, and #31 of an 18-year-old male. Clinical history showed self-reported discomfort in the right posterior gingiva for over a month. Physical examination showed a small expansion and redness of the right mandibular buccal and lingual cortical plates, but no signs of pain or inflammation were observed. All the teeth responded positively to pulp sensibility. Periapical and panoramic radiographs showed slight periapical radiolucency in the roots of teeth #29 and #30, clear periodontal ligament space widening, and evident loss of lamina dura. Incisional biopsy was performed, and based on microscopic findings the diagnosis of chondroblastic osteosarcoma was confirmed. Conclusions Non-endodontic diseases associated with tooth root apex, such as chondroblastic osteosarcoma, should be included in differential diagnosis of jaw lesions that resemble periapical abscess.

Paraendodontic surgery: case report / Cirurgia paraendodôntica: relato de caso

ABSTRACT Paraendodontic surgeries have been increasingly used to solve problems related to failures in conventional endodontic treatment. Better anatomical knowledge of the structures as well as the development of techniques and materials involved has resulted in substantial paraendodontic surgery increase and success. In some cases, teeth endodontic treatment highly benefits treatment accomplishment. This report describes a case of an endodontic treatment complemented by paraendodontic surgery in periapical region of 21, 22 and 23 of a female patient who had been treated at the clinic of the Brazilian Dental Association Dentistry - in the city of Cascavel, State of Parana, Brazil. The case presents a 12-month follow-up for the resolution of painful symptoms, lesion reduction, and bone formation. Literature review was performed regarding paraendodontic surgery in order to assess the determining factors, failure causes and procedure indications/contraindications, as well.

RESUMO A cirurgia paraendodôntica tem sido cada vez mais utilizada para sanar problemas inerentes aos insucessos no tratamento endodôntico convencional. O melhor conhecimento anatômico das estruturas envolvidas bem como a evolução das técnicas e dos materiais proporcionou um aumento significativo da utilização desta técnica e, por conseguinte seu maior sucesso. O tratamento endodôntico primário de um elemento dentário pode atingir altos índices de sucesso. Tornando-se, portanto, imprescindível para se atingir o sucesso do tratamento de alguns casos. Neste trabalho descreve-se um caso de tratamento endodôntico complementado por cirurgia paraendodôntica em região periapical dos elementos dentais 21, 22 e 23 de paciente do gênero feminino que foi tratada na Clínica de Odontologia da Associação Brasileira de Odontologia - Regional de Cascavel, Pr. O caso apresenta acompanhamento de 12 meses com resolução da sintomatologia dolorosa, redução da lesão e neoformação óssea. Foi realizada uma discussão com revisão da literatura sobre a cirurgia paraendodôntica avaliando os fatores determinantes, causas de insucessos, indicações e contraindicações do procedimento.

Analysis of Interleukin 17A in periapical abscess and granuloma lesions

Abstract Interleukin 17A (IL-17A) is a proinflammatory cytokine responsible for the initiation and propagation of inflammation. One of its actions is the recruitment of neutrophils to the site of infection. The aim of this study was to investigate whether there is association between IL-17A expression and neutrophil infiltration in periapical abscesses and periapical granulomas, as well as to find which type of T lymphocyte effector (CD4+ or CD8+) expresses IL-17A in these lesions. Elastase, CD4, CD8, and IL-17A were analyzed by immunohistochemistry and immunofluorescence, in the biopsies of periapical lesions. Abscess lesions exhibited the highest labeling area for IL-17A (p = 0.011). During double immunofluorescence staining, there were significantly more CD4+/IL-17A+ cells compared to CD8+/IL-17A+ cells, both in the abscesses (p = 0.025) and granulomas (p = 0.011). In conclusion, IL-17A was intensively expressed in periapical abscesses rich in neutrophils. The high percentage of IL-17A in these cases suggests the participation of this cytokine particularly in the acute stages of the inflammatory process of the periapical lesions.

Complicaciones derivadas del absceso dentoalveolar agudo en pacientes pertenecientes al área VII, Cienfuegos (2013) / Complications caused by acute dentoalveolar abscess in patients from Health Area VII in Cienfuegos, 2013

Introducción: las complicaciones derivadas del absceso dentoalveolar agudo constituyen un tema de preocupación para el estomatólogo, debido al riesgo que generan para el estado de salud en general, a pesar de esto existen pocos estudios específicos sobre el tema. Objetivo: describir las complicaciones derivadas del absceso dentoalveolar agudo en pacientes pertenecientes al área VII, Cienfuegos. Métodos: se realizó investigación observacional, descriptiva, transversal en el periodo comprendido de enero a diciembre de 2013. El universo fue de 374 pacientes que acudieron con absceso alveolar agudo, y la muestra 87 que derivaron en alguna complicación. La fuente para obtener información fue la observación. El registro primario de datos y recolección de la información se obtuvo mediante la historia clínica individual, luego de obtener el consentimiento informado de los pacientes. Principales variables: edad, sexo, dientes afectados con mayor frecuencia, comportamiento de las complicaciones ante tratamiento de elección y automedicación, factores sistémicos asociados y complicaciones derivadas del absceso dentoalveolar agudo. Los resultados se expresaron en total y porcentajes. Resultados: el sexo femenino estuvo afectado con las complicaciones derivadas del absceso dentoalveolar agudo (72,41 por ciento), y el grupo de edad de 35-59 años en 34,48 por ciento. El segundo premolar superior se afectó en 28,74. El 71,26 por ciento respondió de manera positiva ante tratamiento de elección. La diabetes mellitus tipo I y II como factor sistémico se mostró en 53,33 por ciento; la celulitis facial odontógena leve apareció como complicación en 64,36 por ciento. Conclusión: Las complicaciones derivadas del absceso dentoalveolar agudo fueron la celulitis facial odontógena leve y moderada; las mujeres fueron las más afectadas. El padecimiento de enfermedades sistémicas agravó más el cuadro clínico; pero el rápido tratamiento indicado por el facultativo para impedir casos, fatales(AU)

Introduction: complications caused by acute dentoalveolar abscess are a reason for concern among dentists, due to the risk they pose for the patients' overall health status. However, few specific studies have been published on the subject. Objective: describe the complications caused by acute dentoalveolar abscess in patients from Health Area VII in Cienfuegos. Methods: a cross-sectional observational descriptive study was conducted from January to December 2013. The study universe was 374 patients attending the dental service with acute alveolar abscess, and the sample was 87 who had some sort of complication. Data were obtained by observation. Primary data and information were collected from the patients' medical records after obtaining their informed consent. The main variables analyzed were age, sex, teeth most commonly affected, behavior of complications vs. treatment of choice and self-medication, associated systemic factors and complications caused by acute dentoalveolar abscess. Results were expressed as total and percentages. Results: 72.41 percent of the female patients and 34.48 percent of the 35-59 age group were affected by complications caused by acute dentoalveolar abscess. The upper second premolar was affected in 28.74 percent of the cases. 71.26 percent of the patients responded positively to the treatment of choice. Diabetes mellitus types I and II as a systemic factor was found in 53.33 percent of the cases, whereas mild odontogenic facial cellulitis appeared in 64.36 percent. Conclusion: mild and moderate odontogenic facial cellulitis were the complications caused by acute dentoalveolar abscess. Women were more affected than men. Systemic diseases aggravated the clinical status of patients, but the swift action of dentists prevented the occurrence of fatal cases(AU)

El absceso dentoalveolar agudo como urgencia estomatológica en pacientes adultos / Acute dentoalveolar abscess as a dentist emergency in young adults

Introducción: en la práctica estomatológica, uno de los procesos periapicales más comúnmente observados en los servicios de urgencias, es el absceso dentoalveolar agudo. Objetivo: describir el comportamiento del absceso dentoalveolar agudo como urgencia en la población adulta. Material y método: se realizó un estudio descriptivo, de corte transversal en la Clínica Estomatológica “Hermanos Saiz” del municipio San Juan y Martínez, Pinar del Río, de septiembre de 2013 a septiembre de 2014. El universo estuvo constituido por 120 pacientes con diagnóstico de absceso dentoalveolar agudo según las características clínicas y antecedentes del paciente obtenidos en el interrogatorio. De ellos, se seleccionaron 80 pacientes al azar como muestra. Se procesaron los datos manualmente y presentaron en tablas utilizando el por ciento como medida resumen. Resultados: el mayor número de pacientes afectados correspondió al sexo masculino con un predominio del grupo de edad de 35-59 años. Las fases clínicas I y II fueron las más frecuentes, los molares inferiores resultaron las piezas dentarias más vulnerables; el dolor fue el síntoma más prevaleciente, mientras que nadie acudió aquejado por presentar malestar general. El diagnóstico de esta patología en estadio inicial (fase I) es directamente proporcional a una evolución favorable del cuadro clínico. Conclusiones: se describió el comportamiento del absceso dentoalveolar agudo como urgencia en la población adulta, lo que posibilita proponer nuevas investigaciones sobre factores relacionados con el origen y prevención de dicha enfermedad.

Introduction: in dentistry practice, one of the periapical processes, the most common observed in emergency services, is the acute dentoalveolar abscess. Objective: to describe the behavior of acute dentoalveolar abscess as an emergency in the adult population. Material and Method: a descriptive, cross-sectional study was conducted at Hemanos Saiz Dentist Office from San Juan y Martinez, Pinar del Río (September 2013-2014). The target group was comprised of 120 patients with acute dentoalveolar abscess, according to the clinical characteristics and history of patient, known by the interview. Out of them, 80 patients were taking as a sample at random; processing data manually and presented in tables percentage method to sum it up. Results: male patients were the most affected, ages from 35 to 59 predominated. Clinical phases I and II were the most frequent found, inferior molars showed the highest vulnerability; pain was the prevailing symptom, while nobody complained of malaise. The diagnosis of this pathology in early stages (I) is directly proportional of a favorable natural history of the clinical chart. Conclusions: the behavior of acute dentoalveolar abscess as an emergency in adult population was described, which made possible the proposal of new researches about related factors to the origin and prevention of such entity.

Comportamiento clínico epidemiológico del absceso dentoalveolar agudo en pacientes pertenecientes al área VII de Cienfuegos / Clinical and Epidemiological behavior of Acute Dentoalveolar Abscess in Patients of the Health Area VII in Cienfuegos

Fundamento: el absceso dentoalveolar agudo es una de las urgencias estomatológicas y una de las principales enfermedades que afectan a la población, sin embargo existen muy pocos estudios sobre el tema.Objetivo: describir comportamiento clínico epidemiológico del absceso dentoalveolar agudo en pacientes pertenecientes al área VII, de Cienfuegos. Métodos: investigación observacional, descriptiva realizada de enero a diciembre de 2013 en el Área VII, de Cienfuegos. El universo fue de 672 pacientes y la muestra de 374, escogida mediante muestreo probabilístico aleatorio simple. El registro primario de datos y recolección de la información se obtuvo mediante la historia clínica individual previo consentimiento informado a los pacientes. Las principales variables fueron: edad, sexo, irritantes pulpares.Resultados: el sexo más afectado fue el femenino con 55,35 % y el grupo de edad el de 19 a 34 con 33,69 %.El irritante pulpar predominante fue el microbiano 59,36 %. Dentro de los factores iatrogénicos, los restos de tejidos cariados se destacaron con un 32,35 %.Conclusiones: existe un número elevado de pacientes con absceso dentoalveolar agudo, por lo que, como urgencia estomatológica, debe ser una preocupación del estomatólogo conocer las características, comportamiento y factores que desarrollan la enfermedad, para propiciar un trabajo integral en cuanto a la promoción de salud, prevención, curación y rehabilitación de los pacientes afectados.

Background: acute dentoalveolar abscess is a dental emergency and one of the major condition affecting the population; however, there are few studies on the subject. Objective: to describe the clinical and epidemiological characteristics of acute dentoalveolar abscess in patients of the health area VII in Cienfuegos. Methods: a descriptive study was conducted from January to December 2013 in the Health Area VII, Cienfuegos. The universe consisted of 672 patients and the sample included 374 individuals selected by simple random sampling. Primary data recording and data collection was obtained from medical records prior informed consent of the patients. The main variables were age, sex, pulp irritating agents. Results: females were more affected with 55, 35% and the 19-34 year age group with 33.69%. The main pulp irritator was microbial, 59.36%. Among the iatrogenic factors, the remains of decayed tissues were significant with 32.35%. Conclusions: there is a high number of patients with acute dentoalveolar abscess, thus, as a dental emergency, the dentist should know the characteristics and factors that develop the disease to promote a comprehensive job in terms of health promotion, prevention, treatment and rehabilitation of affected patients.

Antibióticos no tratamento de abscessos perirradiculares agudos / Antibiotics in the treatment of acute periradicular abscesses

O abscesso perirradicular agudo pode resultar em complicações sistêmicas, sendo necessária a antibioticoterapia coadjuvante ao tratamento clínico. No entanto, os antibióticos são frequentemente prescritos pelos cirurgiões-dentistas no tratamento destas infecções em algumas situações questionáveis. É importante destacar que o uso incorreto destes agentes terapêuticos pode levar ao surgimento de micro- -organismos resistentes. O objetivo da presente revisão de literatura é descrever a antibioticoterapia no tratamento de abscessos perirradiculares agudos, abordando suas indicações e drogas utilizadas, e discutir a resistência bacteriana a alguns antibióticos.

The acute periradicular abscess can result in systemic complications, being necessary a complementary antibiotic therapy to clinical treatment. However, antibiotics are often prescribed by dentists to treat these infections, but its use is questionable in some situations. Misuse of antibiotics can lead to the emergence of resistant micro-organisms. The aim of this present literature review is to describe the antibiotic treatment in acute periradicular abscesses by addressing its indications and drug use, and discuss about bacterial resistance to some antibiotics.

Visión contemporánea de las infecciones odontogénicas / Contemporary vision of odontogenic infections

Las infecciones odontogénicas son condiciones clínicas graves y de ocurrencia relativamente común, caracterizadas por la rápida diseminación del proceso infeccioso a los tejidos adyacentes y espacios faciales de la región de la cabeza y cuello, pudiendo llevar al paciente a la muerte. Las infecciones que acontecen en la cavidad bucal son un problema de salud pública, pues u origen podría ser evitado con un tratamiento preventivo. Estas constituyen uno de los problemas más difíciles de tratamiento en odontología, sobre todo en nuestro país, donde grande parte de la población todavía posee índices de caries y enfermedad periodontal elevados, siendo la necrosis de la pulpa dental, resultante de caries profunda la principal causa, donde es creada una vía para que las bacterias penetren en los tejidos periapicales estableciendo una infección activa que irá a diseminarse preferencialmente a lo largo de líneas de menor resistencia. Estos procesos infecciosos pueden variar desde infecciones bien localizadas, que exigen un tratamiento mínimo, hasta infecciones de alta complejidad que envuelven un tratamiento multidisciplinario en ambiente hospitalario generando altos costos y sufrimiento al paciente. Así, compréndase que las medidas preventivas en salud pública son capaces de evitar el empeoramiento de procesos infecciosos en fase inicial y consecuentemente promueven una disminución de la morbilidad y mortalidad.

The odontogenic infections are serious clinical conditions and relatively common occurrence, characterized by the rapid spread of the infectious process to adjacent tissues and fascial spaces of head and neck, which may lead the patient to death. Infections that affect the oral cavity are a public health problem, because their origin could be avoided with preventive treatment. These are one of the most difficult problems in dental treatment, especially in our country where much of the population still has rates higher caries and periodontal disease, with necrosis of the dental pulp resulting from the leading cause deep cavity, where it created a way to penetrate the bacteria in periapical tissues establishing an active infection that will spread preferentially along the lines of least resistance. These infectious processes can vary from highly localized infections that require minimal treatment, even infections that involve a highly complex multidisciplinary treatment in a hospital environment by generating high costs and suffering to the patient. Thus we understand that preventive measures in public health are able to avoid the aggravation of infectious processes in the initial phase and thus promote a decrease in morbidity and mortality.

Ultrasound imaging versus conventional histopathology in diagnosis of periapical lesions of endodontic origin: A comparative evaluation.

Context: Accurate assessment of periapical status is critical in diagnosis, treatment planning, and evaluation of healing. Novel imaging modalities like sonography offer promising results with reduced radiation risks. Aims: To evaluate the potential of ultrasound imaging technique together with the application of color Doppler to differentiate between periapical lesions of endodontic origin. Materials and Methods: Twenty patients with periapical lesions of endodontic origin who were already scheduled for undergoing endodontic surgery were examined further using sonography. Color Doppler was performed to assess blood flow. Information on the size of the lesion, its content, and vascular supply was gained and recorded by means of ultrasound images. The sonographic images were analyzed and discussed with an expert sonologist, and a tentative diagnosis between a periapical cyst and periapical granuloma was made. Endodontic surgery and histopathological examination was done for each case and the results were compared. Results: The sonograms revealed the lesions within the bone in three dimensions and their contents, that is, fluids or tissues or blood vessels. Measurements of the periapical lesions in three dimensions were also obtained. Of the twenty cases studied, ultrasound could detect periapical granulomas in all 9 cases and radicular cysts in all 11 cases. Conclusion: Ultrasound imaging had the potential to be used for the evaluation of periapical lesions of endodontic origin. However, further studies are required to establish a definite correlation.