Efecto de las células madre derivadas del tejido adiposo en las arrugas periorbitarias / Effect of Adipose Tissue-derived Stem Cells on Periorbital Wrinkles

Objetivo: Evaluar el efecto de las células madre derivadas del tejido adiposo en el tratamiento de las arrugas periorbitarias. Métodos: Ensayo comparativo aleatorizado doble ciego en el Servicio de Cirugía Plástica del Hospital Ameijeiras, en el período comprendido entre septiembre de 2019 y julio de 2021. La muestra quedó formada por 70 pacientes que cumplieron los criterios de selección que se distribuyeron en dos grupos de tratamiento. Resultados: Predominaron las mujeres (88,6 por ciento) con promedio de edad de 47 años sin diferencias significativas entre los grupos de tratamiento. El 60,0 por ciento del grupo estudio y el 62,9 por ciento del control presentaron fototipo cutáneo II sin diferencias significativas entre los grupos (p= 0,855). El mayor porcentaje del grado de envejecimiento correspondió al III y el menor al IV (14,3 por ciento contra 20,0 por ciento), sin diferencias significativas entre los grupos (p= 0,487). Antes del tratamiento, hubo mayor frecuencia de arrugas moderadas (estudio: 42,9 por ciento; control: 51,4 por ciento) y severas (estudio: 42,9 por ciento; control: 34,3 por ciento). Posterior a la intervención, se constató una mejoría superior en el grupo estudio con cambios significativos en ambos conjuntos tratados (p< 0,001). Se presentó una complicación del grupo control (2,9 por ciento); 100 por ciento quedó satisfecho y los resultados fueron buenos en el grupo estudio (94,3 por ciento) y regulares en igual proporción del control con diferencias significativas (p< 0,001). Conclusiones: La lipotransferencia asistida con células madre ofrece resultados superiores a la convencional en el rejuvenecimiento periorbitario(AU)

Objective: To evaluate the effect of adipose tissue-derived stem cells in the treatment of periorbital wrinkles. Methods: Randomized double-blind comparative trial in the Plastic Surgery Service of the Clinical Surgical Hospital "Hermanos Ameijeiras" in the period since September/2019 until July/2021. The sample consisted of 70 patients who met the selection criteria and were distributed into two treatment groups. Results: Women predominated (88.6 percent) with an average age of 47 years with no significant differences between the treatment groups. The 60.0 percent of the study group and 62.9 percent of the control group presented skin phototype II with no significant differences between the groups (p= 0.855). The highest percentage of aging corresponded to III and the lowest to IV (14.3 percent vs. 20.0 percent), with no significant differences between the groups (p= 0.487). Before treatment, there was a higher frequency of moderate (study: 42.9 percent; control: 51.4 percent) and severe wrinkles (study: 42.9 percent; control: 34.3 percent). After the intervention, there was a superior improvement in the study group with significant changes in both treated groups (p< 0.001). There was one complication in the control group (2.9 percent). 100 percent were satisfied and the results were good in the study group (94.3 percent) and regular in equal proportion of the control with significant differences (p< 0.001). Conclusions: Stem cell-assisted lipotransfer offers superior results to conventional lipotransfer in periorbital rejuvenation(AU)

Usefulness of Monopolar Thermal Radiofrequency Treatment for Periorbital Wrinkles

BACKGROUND: Over the past 10 years, monopolar radiofrequency (MRF) technology has been widely used by dermatologists as a valuable modality to effectively tighten and rejuvenate photoaged skin. It also has the benefit of a short recovery time. OBJECTIVE: Using an objective parameter, this study aimed to assess the efficacy and safety of MRF, which is the basic modality of radiofrequency technologies, for treatment of periorbital wrinkles in Korean patients. METHODS: We enrolled 70 middle-aged female patients with periorbital wrinkles for this study. Each patient underwent triple sessions of MRF treatment in the periorbital region, separated by 2-week intervals. Clinical photographs were obtained, and the areas of wrinkles were measured using a Robo Skin Analyzer CS50 (Inforward Inc., Japan) at baseline and 4 weeks after the final treatment session. RESULTS: Significant reduction in the mean area of periorbital wrinkles was detected at 1-month follow-up (80.64±28.96 mm2) compared to baseline (95.08±31.93 mm2). The improvement ratio of the wrinkle area was 15.19%. Pain during procedure seemed to be tolerable without any local anesthesia for all patients. Transient mild erythema was the only side effect reported during the study. CONCLUSION: In conclusion, MRF could still be an attractive modality for Korean patients with periorbital wrinkles if the treatment is conducted repeatedly with sufficient energy and proper intervals.

Efficacy of Biodegradable Microneedle Patches on Periorbital Wrinkles / 대한피부과학회지

BACKGROUND: Biodegradable microneedle technology is a recently developed method to deliver medical and pharmaceutical medications into the skin, and is expected to yield better treatment results than topical application methods. OBJECTIVE: To evaluate the efficacy of hyaluronic acid (HA)-based microneedle patches and epidermal growth factor (EGF)-containing microneedle patches on periorbital wrinkle improvement. METHODS: A 20-week randomized, double-blind study was performed. Twenty-five Korean patients with periorbital wrinkles and a wrinkle severity rating scale (WSRS) score above 2 were enrolled into the study. The patients completed the study using the two different types of patches on each side of the designated periorbital wrinkles area every other day for 8 weeks. Patients were requested for an additional 12-week follow up. Wrinkle improvements were assessed by WSRS score, subjective patient satisfaction score, and imaging analysis using the visiometer, corneometer, cutometer, and mexameter, respectively (Courage&Khazaka, Cologne, Germany). RESULTS: Both the HA-based microneedle patch and EGF-containing HA-based microneedle patch had positive effects on WSRS score, patient satisfaction levels, and corneometer result with statistically significant differences. No significant side effects were noticed. CONCLUSION: With respect to efficacy, no statistical difference between the two groups were noted, indicating that the anti-wrinkle effects of the microneedle patch may solely be due to the HA rather than the EGF.