ABSTRACT
Alveolar epithelial apoptosis and injury induced by oxidative stress in pulmonary diseases have drawn great attention from researchers. Peroxiredoxin 6 (Prdx6), endowed with the activities of both glutathione (GSH) peroxidase and phospholipase A2(PLA2), can effectively fight against oxidative stress and alleviate oxidative stress-induced lung injury, and therefore plays an important role in pulmonary diseases. This review focuses on the structure, function, distribution and expression regulation of Prdx6, and summarizes the role of Prdx6 in pulmonary antioxidant defense and its regulatory mechanism based on experimental studies.
ABSTRACT
Objective To investigate and observe the expression of Peroxiredoxin Ⅵ in iechemia cortex of rats and the intervention effect of Xingnao Kaiqiao Acupuncture(XKA) therapy. Methods Through western blotting,we detected the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group , comparison group, model group and sham operation group in middle cerebral artery occlusion (MCAO)model of rats. Results At 6h, the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group , comparison group and sham operation group was increased than that in moddle group,of which Xingnao Kaiqiao group increased obviously(P < 0.05). At 24h, as compared with modlegroup, the expression of Peroxiredoxin Ⅵ in xingnao kaiqiao group and comparison group increased significantly (P < 0.05). Conclusion Xingnao Kaiqiao Acupuncture therapy could raise the expression of Peroxiredoxin Ⅵ in focal cerebral ischemia of rats, and the effect is better that of traditional acupuncture therapy in the earlier period.It is benefit to elevating the ability of antioxygen of focal cerebral ischemia of rats.