Preparation of β-elemene-polybutylcyanoacrylate nanoparticles / 中草药

Objective: Optimizing the formula and preparation of β-elemene- polybutylcyanoacrylate nanoparticles (β-ELE-PBCA-NP). Methods: With polybutylcyanoacrylate (PBCA) as the drug-loaded material, β-ELE-PBCA-NP was prepared by interfacial polycondensation. The preparation conditions were optimized by single factor design and the formula was optimized by orthogonal design with entrapment efficiency (EE) as index. EE of β-ELE-PBCA-NP was determinated by RP-HPLC. Results: Under the optimal conditions, the prepared NPs were round and regular in shape without adhesions with average particle size of 254 nm and EE of 90.17%. Conclusion: The optimized technology in this experiment is stable and feasible.