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1.
Journal of Korean Neurosurgical Society ; : 186-193, 2018.
Article in English | WPRIM | ID: wpr-788675

ABSTRACT

OBJECTIVE: The purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats.METHODS: Male Sprague-Dawley rats were randomly assigned to three groups (n=25/group); näive, sham, and C2 resection. Three, 7, 10, and 14 days after surgery, cold allodynia was assessed using 20 μL of 99.7% acetone. c-Fos and c-Jun were immunohistochemically stained to evaluate activation of dorsal horn gray matter in C2 segments of the spinal cord 2 hours, 1 day, 7 days, and 14 days after surgery.RESULTS: Three days after surgery, the response to acetone in the sham group was significantly greater than in the näive group, and this significant difference between the näive and sham groups was maintained throughout the experimental period (p < 0.05 at 3, 7, 10, and 14 days). Seven, 10, and 14 days after surgery, the C2 root resection group exhibited a significantly greater response to acetone than the näive group (p < 0.05), and both the sham and C2 resection groups exhibited significantly greater responses to acetone compared with 3 days after surgery. No significant difference in cold allodynia was observed between the sham and C2 root resection groups throughout the experimental period. Two hours after surgery, both the sham and C2 root resection groups exhibited significant increases in c-Fos- and c-Jun-positive neurons compared with the naive group (p=0.0021 and p=0.0358 for the sham group, and p=0.0135 and p=0.014 for the C2 root resection group, respectively). One day after surgery, both the sham and C2 root resection groups exhibited significant decreases in c-Fos -positive neurons compared with two hours after surgery (p=0.0169 and p=0.0123, respectively), and these significant decreases in c-Fos immunoreactivity were maintained in both the sham and C2 root resection groups 7 and 14 days after surgery. The sham and C2 root resection groups presented a tendency toward a decrease in c-Jun-positive neurons 1, 7, and 14 days after surgery, but the decrease did not reach statistical significance.CONCLUSION: We found no significant difference in cold allodynia and the early expression of c-Fos and c-Jun between the sham and C2 resection groups. Our results may support the routine resection of the C2 nerve root for posterior C1–2 fusion, but, further studies are needed.


Subject(s)
Animals , Humans , Male , Rats , Acetone , Gray Matter , Hyperalgesia , Neuralgia , Neurons , Rats, Sprague-Dawley , Spinal Cord , Spinal Cord Dorsal Horn
2.
Journal of Korean Neurosurgical Society ; : 186-193, 2018.
Article in English | WPRIM | ID: wpr-765245

ABSTRACT

OBJECTIVE: The purpose of this study was to evaluate pain-related behaviors after bilateral C2 root resection and change in pain patterns in the suboccipital region in rats. METHODS: Male Sprague-Dawley rats were randomly assigned to three groups (n=25/group); näive, sham, and C2 resection. Three, 7, 10, and 14 days after surgery, cold allodynia was assessed using 20 μL of 99.7% acetone. c-Fos and c-Jun were immunohistochemically stained to evaluate activation of dorsal horn gray matter in C2 segments of the spinal cord 2 hours, 1 day, 7 days, and 14 days after surgery.


Subject(s)
Animals , Humans , Male , Rats , Acetone , Gray Matter , Hyperalgesia , Neuralgia , Neurons , Rats, Sprague-Dawley , Spinal Cord , Spinal Cord Dorsal Horn
3.
The Journal of the Korean Orthopaedic Association ; : 778-781, 2005.
Article in Korean | WPRIM | ID: wpr-654383

ABSTRACT

Segmental C1-2 screw fixation using C1 lateral mass screws and C2 pedicle screws is a technically demanding procedure which can cause injuries to the vertebral artery or neural structures as well as massive bleeding from the epidural venous plexus. In particular, this procedure is more difficult in revision cases because of the lack of normal anatomical landmarks, adhesion, and bleeding. The authors report a case of a patient in whom preoperative surgical simulation and planning using computer software was very helpful in the direct screwing of the atlas and axis for a revision of atlantoaxial fusion.


Subject(s)
Humans , Axis, Cervical Vertebra , Computer Simulation , Hemorrhage , Vertebral Artery
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