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Objective To study the main factors affecting the preparation of osthol ( Ost ) loaded solid lipid nanoparticies ( SLN ) . Methods The SLN were prepared by melt-homogenization method. The optimum formulation and process were selected by orthogonai design. The shape, particle size, loading capacity were investigated. Results The obtained Ost-loaded SLN were sphere or oval at a range of 100-200 nm, and were well distributed without adhesion, the loading capacity was 59. 78%. Conclusion The melt-homogenization method is available for the preparation of Ost loaded SLN.
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OBJECTIVE:To optimize the extraction technics of liver-strengthening cholagogue oral preparation.METHODS:The effects of the four factors-the quantity of the added water,the decoction time,the decoction times and the alcohol precipitation concentration on the extraction results were determined with content of total flavonoids taken as index.RESULTS:The best extracting condition was the following,the amount of the added water was 10 times that of the medicinal materials,the decoction duration was 60min,the alcohol precipitation concentration was 50%and the decoction was carried out twice.CONCLUSION:The preparation under this technics is of high clarity and stable contents.
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OBJECTIVE:To optimize the preparation technics and the formula of gatifloxacin dispersible tablets.METHODS:The adjuvant like disintegrant etc.,the formula and preparation process were optimized by a series of experi-ments.The dissolution rates of the principal agent in dispersible tablet and conventional tablet were determined and compared.RESULTS:Sodium carboxymethyl starch and crospolyvinylpyrrolidone were optimized as the disintegrants of the dispersible tablet formula;The dissolution rate of the dispersible tablet was faster than that of the conventional tablet.CONCLUSIONS:The prepared gatifloxacin dispersible tablet is reasonable in formula,feasible in technology and it meets the quality standards.
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Objective:Shenkang was prescribed and prepared by our own hospital and its clinical effect and side effect for treating latent glomerulonephritis(LGN) were observed. Methods: Shenkang was composed of dog's penis Carapar Trionycis、nephritis herb and so on and prepared by the modern pharmaceutical technology. 60 cases with LGN were divided into the control group(30 cases) and the Shenkang group(30 cases) at random. Patients with protein uria in the control group were treated with the tablet of multiglycoside of Radix Tripterygii Wilfordi and patients with accompanied symptom were treated by the supportive expectant treatment. Patients in the Shenkang Capsule group were treated with it, 5 tables each time, 3 times a day and patients with accompanied symptom were also treated by the supportive expectant treatment. The treatment courses of two groups were all 3 months. 24 hour protein uria quantity、 serum total protein(TP)、 albumin(Al)、 1 hour urine red blood cell excreting rate(1huRBCer)、 serum creatinine and sodium before and after the treatment were observed. Results: Shenkang Capsule can significantly lower protein uria of LGN so as to raise the levels of TP and Al and reduce 1huRBCer. There was no side effect in the course of using Shenkang Capsule. Conclusion: Shenkang Capsule is effective for LGN.