ABSTRACT
AIM: To study the relationship between prostaglandins and acute pulpitis. METHODS: Rat traumatic pulpitis model was established by pulp exposure. The kinetic pathological changes in dental pulpal tissues and changes of PGE 2?6-Keto-PGF 1? and TXB 2 concentration in dental pulp were observed. RESULTS: After pulpal trauma, the dental pulp showed inflammatory changes and the concentrations of PGE 2?6-Keto-PGF 1? and TXB 2 were increased, which peaked at 6 hour post-trauma. CONCLUSION: Prostaglandins play a significant role in the pathogenesis of pulpitis.
ABSTRACT
AIM: To study the effect of local application of indomethacin on acute pulpitis. METHODS: Traumatic pulpitis model in rats was established by means of pulp exposure, radioimmunoassay (RIA) was used to measure the kinetic changes of the levels of PGE_2、6-keto-PGF_~1? and TXB_2 of pulpal tissues. RESULTS: Local application of indomethacin could more effectively inhibit the cyclo-oxygenase pathway than zinc oxide engenol in the early stage of pulpitis and reduce the production of prostaglandins. CONCLUSION: Local application of indomethacin may have a therapeutic effect on acute pulpitis. [