Pseudomonas Keratitis Due to Mishandling of Soft Contact lenses

Causative bacterias of keratitis due to mishandling of contact lenses are mainly Gram negative rods, and large percentage of them are Pseudomonas. We experienced 6 cases of culture-proven Pseudomonas keratitis due to mishandling of soft contact lenses and wetting solution can be cultured. They are lack of education as how handle the contact lenses safely. And they did not done disinfection of the soft contact lens cases. To prevent contact lens related keratitis, we think it is very important for users to know its possible complication and how to use it and disinfect it safely.

The Topical Effects of Antibiotics and Aprotinin in Experimental Pseudomonas Ketaititis

The effects of the topically applied antibiotics and Aprotinin were evaluated in the experimentally induced pseudomonas aeruginosa keratitis in rabbits. 40 albino rabbits were used for this study and were divided into 8 groups according to the treatment protocols as follows: Aprotinin 40u/ml, 1,OOOu/ml, 1O,000u/ml, antibiotics (Ciprofloxacin and Tobramycin), and antibiotics and Aprotinin combined-treated group. The drugs were instilled in the rabbits, cornea 6 times per day for 2 weeks. The clinical evaluation was performed using a hand-held slit lamp every day. For the histopathologic examination, we enucleated every samples at different time intervals and prepared specimens for light microscope. The results were Aprotinin-treated group showed progression of ulcer infiltrates regardless of its concentrations. There was a statistically significant difference between the antibiotics-treated group and the control group (p0.05). There was no clinical and histopathological differences in the rabbit cornea between ciprofloxacin and tobramycin treated group (p>0.05).

The Effect of Topical Antibiotics on the Experimental Pseudomonas Keratitis

Recently, acute pseudomonas keratitis is reported to occur more frequently. If treatment is not adequate after the invasion of Pseudomonas into the cornea, corneal perforation ensues within 48 hours. Hence the rapid diagnosis and treatment is required, and the treatment mostly depends on the antibiotics. Pseudomonas keratitis induced in the rabbit cornea by inoculating Pseudomonas aeruginosa (lID 1210). Then the keratitis was treated with topical antibiotics available in Korea Chloramphenicol(R), Polyspectran(R), Tobra(R), Gentamicin(R), Tarivid(R). The effect of the antibiotics on Pseudomonas keratitis was evaluated clinically as well as bacteriologically and irritation of the antibiotics against the eye was also obsesved. 1. Polyspectran(R), tobra(R), gentamicin(R), tarivid(R) treated experimental Pseudomonas keratitis in the rabbit eyes but chloramphenicol(R) and saline did not inhibit the bacterial growth of the rabbit corneas. 2. Against the rabbit eyes, chloramphenicol(R) and polyspectran(R) were the most irritable aptibiotics, where as Gentamicin(R) and tarivid(R) were the moderate, and tobra(R) and saline were the least in the extent of irritation.