ABSTRACT
Objective To study the correlation between CT features and pulmonary function indexes in dif-ferent chronic obstructive pulmonary diseases(COPD).Methods Collection of COPD patients with 80 cases were collected,,the correlation analysis of COPD CT features (pixel index)and pulmonary function,including one second forced expiratory volume (FEV1 ),one second forced expiratory volume accounted for the percentage of forced vital capacity (FVC)and residual volume /lung total ratio (RV /TLC)were examined by pulmonary function testing (PFT)and multislice spiral CT (MSCT).Results According to CT,the regional area of lung density (LAA%)and airway wall thickness/lumen area were measured,COPD was divided into 56 cases of emphysema phenotype,13 case of airway phenotype and 11 case of mixed phenotype.The emphysema phenotype index,FEV1 ,FEV1 /FVC pixels,RV /TLC =27.68%,(32.19 ±16.78)%,(43.69 ±11.23),(55.67 ±15.49 ),airway phenotype were 5.23%, (55.67 ±23.12)%,(52.30 ±10.67),(49.48 ±13.27),respectively,mixed phenotype were 22.47% (41.23 ± 12.55)%,(47.31 ±9.98),(54.19 ±16.29),FEV1 ,FEV1 /FVC,pixel index,RV /TLC COPD CT in different phe-notypic differences were statistically significant (χ2 =19.013,F =6.234,7.854,6.389,all P 0.05).Conclusion CT features can be regarded as the reference to diagnosis the COPD pheno-type and evaluate the effect of treatment,it is necessary to re -examine PFT in emphysema and airway phenotypes.
ABSTRACT
Objective To investigate the effect of Ambroxol on NF?B activation of macrophage in the induced sputum in patients with stable COPD.Methods Induced sputum was taken from 47 stable COPD patients,who were divided into two groups randomly.Macrophages were collected,and NF-?B activation and IL-8 of induced sputum were determined by immunohistochemistry;SOD and MDA were determined synchronously.Results NF-?B activation in macrophage and IL-8 in the treated group were significantly decreased in patients of stable group than those in the controls.Conclusion Ambroxol can decrease NF-?B activation in macrophage in stable COPD patients.