Evaluación de la calidad de la asistencia pre hospitalaria de pacientes con síndrome coronario agudo / Quality Assessment of Prehospital Care for Patients with Acute Coronary Syndrome

Introducción: La atención médica en el síndrome coronario agudo ha de ir encaminada a tratar, de manera inmediata, las situaciones que puedan comprometer la vida. Los servicios primarios de salud deben ser capaces de administrar una asistencia médica adecuada en la fase aguda prehospitalaria. Objetivos: Evaluar la calidad de la asistencia prehospitalaria de pacientes con síndrome coronario agudo, Métodos: Estudio descriptivo, transversal. Se incluyeron los pacientes atendidos en el Hospital Joaquín Albarrán, en el período enero 2018 - enero 2020, remitidos desde la atención prehospitalaria con el diagnóstico de síndrome coronario agudo. Los datos fueron obtenidos de la remisión del área de salud. Se emplearon 7 criterios para evaluar la calidad de la asistencia. Se utilizó análisis de distribución de frecuencias y fue calculado el porcentaje de cumplimiento de cada uno de los criterios utilizados. Resultados: Se incluyeron 427 pacientes, que tuvieron una edad promedio de 63,2 años. Hubo predominio del sexo masculino y el dolor precordial típico fue la forma de presentación más frecuente. De los siete criterios de calidad, cinco fueron cumplidos de forma satisfactoria. El porcentaje de cumplimiento en el caso de la realización de trombólisis resultó ser de 30,8 por ciento. Conclusiones: Aunque, de manera general, la calidad de la asistencia prehospitalaria que se brinda a pacientes con síndrome coronario agudo es satisfactoria, el uso de la trombólisis no fue óptimo(AU)

Introduction: Medical care in acute coronary syndrome must be aimed at treating, immediately, situations that may compromise life. Primary health services must be able to provide adequate medical care in the acute prehospital phase. Objectives: To assess the quality of prehospital care for patients with acute coronary syndrome, Methods: Descriptive and cross-sectional study carried out with patients treated at Joaquín Albarrán Hospital, in the period from January 2018 to January 2020, referred from prehospital care with a diagnosis of acute coronary syndrome. The data were obtained from the referral records from the health area. Seven criteria were used to assess the quality of care. Frequency distribution analysis was used and percentage of compliance with each of the criteria used was calculated. Results: The study included 427 patients, who had an average age of 63.2 years. There was a predominance of males and typical chest pain was the most frequent onset form. Of the seven quality criteria, five were met satisfactorily. The compliance percentage in the case of thrombolysis was 30.8 percent. Conclusions: Although, in general, the quality of prehospital care provided to patients with acute coronary syndrome is satisfactory, the use of thrombolysis was not optimal(AU)

Regulamentação do estrogênio sintético 17-etinilestradiol em matrizes aquáticas na Europa, Estados Unidos e Brasil / Regulación del estrógeno sintético 17-etinilestradiol en matrices acuáticas en Europa, Estados Unidos y Brasil / Regulation of the synthetic estrogen 17-ethinylestradiol in water bodies in Europe, the United States, and Brazil

O estrogênio sintético 17α-etinilestradiol, principal componente utilizado em formulações de contraceptivos orais, tem sido apontado como um dos principais compostos responsáveis por provocar efeitos adversos no sistema endócrino de várias espécies. O objetivo deste estudo foi analisar o estado da arte dos dispositivos legais e normativos referentes ao controle desse estrogênio sintético nas águas da Europa e dos Estados Unidos, e traçar um paralelo com a realidade brasileira. No geral, os países têm buscado ampliar a regulamentação e monitoramento de alguns micropoluentes emergentes que antes não eram objeto de atenção por parte dos dispositivos legais. A Europa está mais avançada no que tange à qualidade dos corpos hídricos, enquanto que nos Estados Unidos esta substância é alvo de regulamentação apenas para a água destinada ao consumo humano. No Brasil, ainda não há nenhum dispositivo legal ou normativo que aborde esse estrogênio, o que pode ser associado a uma baixa maturidade do sistema brasileiro quanto ao controle de poluentes hídricos.

El estrógeno sintético 17α-etinilestradiol, principal componente utilizado en fórmulas de contraceptivos orales, ha sido apuntado como uno de los principales compuestos responsables por provocar efectos adversos en el sistema endócrino de varias especies. El objetivo de este estudio fue analizar el estado de la cuestión de los dispositivos legales y normativos referentes al control de este estrógeno sintético en las aguas de Europa y de los Estados Unidos, y trazar un paralelo con la realidad brasileña. En general, los países han buscado ampliar la regulación y el monitoreo de algunos microcontaminantes emergentes que antes no eran objeto de atención por parte de los dispositivos legales. Europa está más avanzada en lo que se refiere a la calidad de los cuerpos hídricos, mientras que en los Estados Unidos esta substancia es objeto de regulación solamente para el agua destinada al consumo humano. En Brasil todavía no existe ningún dispositivo legal o normativo que aborde este estrógeno, lo que puede ser asociado a una inmadurez del sistema brasileño respecto al control de contaminantes hídricos.

The synthetic estrogen 17α-ethinylestradiol, the principal component of oral contraceptives, has been identified as one of the main compounds accounting for adverse effects on the endocrine system in various species. This study aimed to analyze the state-of-the-art in legislation and guidelines for the control of this synthetic estrogen in water bodies in Europe and the United States and to draw a parallel with the Brazilian reality. Countries have generally attempted to expand the regulation and monitoring of certain emerging micropollutants not previously covered by legislation. Europe is more advanced in terms of water quality, while in the United States this estrogen is only regulated in water for human consumption. Brazil still lacks legal provisions or standards for this estrogen, which can be explained by the relatively limited maturity of the country's system for controlling water pollutants.

On Quality Criteria of Gengnianjingxin Capsules / 中国药房

OBJECTIVE:To establish the quality criteria for Gengnianjingxin capsules.METHODS:The constituents of Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae etc in Gengnianjingxin capsules were identified by TLC; the content of Paeoniflorin in Gengnianjingxin capsules was determined by HPLC. The chromatographic separation was performed on a ODS-(3)C18 column with mobile phase consisted of acetonitrile-phosphate 0.1% (16∶84) at a flow rate of 1.0mL?min-1. The detection wavelength was 230nm. RESULTS:Fructus Ligustri Lucidi,Radix Polygoni Multiflori,Semen Sesami Nigrum,and Flos Albiziae were all well-separated and clear spots were noted in TLC. The calibration curve was linear for Peoniflorin in the range of 0.256 2～1.281 0?g?mL-1(r=0.999 9), with the average recovery rate of 101.86% and RSD of 1.72%(n=5),CONCLUSION:The established criteria are suitable for the quality control of Gengnianjingxin capsules.

On Quality Criteria of Bushenqiangshen Capsule / 中国药房

OBJECTIVE:To establish quality criteria for Bushenqiangshen capsule. METHODS:TLC was employed to identify Herba Epimedii and Fructus Ligustri Lucidi. HPLC was applied for the determination of content of Icariin. The chromatographic separation was performed on octadecylsilane chemically bonded silica packed column (250mm?4.6mm,5?m). The mobile phase was composed of acetonitrile and methyl alcohol (30∶70) at a flow rate of 1.0mL?min-1. The detection wavelength was 270nm and the column temperature was 30℃. RESULTS:Herba Epimedii and Fructus Ligustri Lucidi were well-separated and clear spots were noted in their TLC. The linear range of icariin was 0.266 4～0.932 4?g (r=0.999 9,n=6), and the average recoveries was 99.77%(RSD=1.89%). CONCLUSION:The established criteria can be used for the quality control of Bushenqiangshen capsules.

Preparation and Quality Criteria of Ru'an Mixture / 中国药房

OBJECTIVE:To preparation Ru'an mixture,and establish its quality standard and observe its therapeutic efficacy.METHODS:Ru'an mixture was prepared with Radix Bupleuri and Ramulus Cinnamomi and Radix Angelicae Sinensis as raw material.Radix Bupleuri,Radix Paeoniae Alba,and Radix Angelicae Sinensis were identified by TLC and the content of Tanshinol was determined by HPLC.RESULTS:The TLC spots of Radix Bupleuri,Radix Paeoniae Alba,and Radix Angelicae Sinensis were all clear.The linear range of Tanshinol was 0.203～2.030?g(r=0.999 8).The total effect rate in Ru' CONCLUSION:Ru'an mixture is reasonable in preparation technique,controllable in quality.

Quality Criteria of Huangzhi Oral Liquid / 中国药房

OBJECTIVE:To establish the quality criteria for Huangzhi oral liquid.METHODS:TLC was employed to for the qualitative identificaiton of Radix et Rhizoma Rhei,Leech and Fructus Arctii;the content of total nitrogen was determined by KjeLdahL determination and content of Chrysophanol in Radix et Rhizoma Rhei in Huangzhi oral liquids was determined by HPLC.RESULTS:The TLC chromatograms of Radix et Rhizoma Rhei,Leech and Fructus Arctii presented the spots of the same colors with those at the corresponding places in the chromatograms of the controls.There was a good linear relationship within the concentration range of 1.696～ 8.480? g? mL-1 for Chrysophanol(r=0.999 8).The average recovery was 99.60%(RSD=1.37%,n=9).CONCLUSION:The methods are accurate and reliable with a strong specificity and can be used for the quality control of Huangzhi oral liquid.

Developmental prospect of subject of Chinese materia medica processing / 中华中医药杂志

In this paper, the author proposed the development direction and study task for processing subject. Its development direction were study of scientific research method and establishment of technological platform for processing-patterns for the scientific research and production combination (enterprise as the mainstay). And its main task will be located at the inheritance of the traditional Chinese medicine pharmaceutical technology, the protection of processing culture as the non-material heritage, and the development of processing as a modern subject.

Isolation and Identification of Coumarin in Dendrobium denneanum Cultivated in Sichuan and Its Quality Standard Study / 中国药房

OBJECTIVE:To establish the quality creteria of Dendrobium denneanum cultivated in Sichuan.METHODS: The reference substance had been isolated and identified.HPLC and TLC were applied for determination and identification respectively.RESULTS: The coumarin control had been successfully isolated and the TLC spots were clear.The linear range of coumarin was 0.096～0.480 ?g with an average recovery of 99.1%(RSD=1.44%,n=6).CONCLUSION: The results can overall reflect the internal quality of D.denneanum cultivated in Sichuan and provide basis for quality evaluation and development of D.denneanum from Sichuan.

Study on Quality Criteria for Fufangzhixueling Granules / 中国药房

OBJECTIVE:To establish the quality criteria for Fufangzhixueling granules.METHODS:TLC was employed to identify Radix Astragali,Rhizoma cimicifuae and Radix Paeoniae Alba,while the content of AstragalosideⅣin Fufangzhix-ueling granules was deteminde by HPLC.RESULTS:TLC findings of Radix Astragali,Rhizoma cimicifuae and Radix Paeoniae Alba showed the spots of same colors as those developed in the corresponding places of control medical materials.The sample size of AstragalosideⅣshowed a good linear relationship within the range of1.551?g～9.306?g(r=0.9996)with the average recovery of97.98%(RSD=1.77%).CONCLUSION:The method is simple,accurate,stable,reliable and with good repro-ducibility,which can be used for the quality control of Fufangzhixueling granules.

Preparation and Quality Criteria of Yigankang Oral Liquid / 中国药房

OBJECTIVE:To prepare Yigankang oral liquid and establish its quality criteria.METHODS: The constituents such as Radix Astragali, Radix Codonopsis and Radix Salvia Miltiorrhiza in Yigankang oral liquid were identified by TLC. The content of Lobetyolin in Yigankang oral liquid was determined by HPLC. RESULTS: The characteristic TLC spots were noted. Lobetyolin showed a good linear relationship in the a range of 0.036～1.317 mg?mL-1(r=0.999 9) and the average recovery was 100.10% with RSD at 1.70%. CONCLUSION: The method is simple and reliable, and it can be used for the quality control of Yigankang oral liquid.

On Quality Criteria of Xiaoyan Tablets / 中国药房

OBJECTIVE:To establish the quality criteria for Xiaoyan tablets. METHODS: Herba Taraxaci and Herba Violae in the formula were identified qualitatively by TLC and the content of Baicalin was determined by HPLC on Zorbax SB-C18(250 mm?4.6 mm,5 ?m) column with mobile phase consisted of acetonitrile-0.4%H3PO4(24∶76) at a flow rate of 1.0 mL?min-1. The detection wavelength was set at 280 nm and the column temperature was set at room temperature. RESULTS: Herba Taraxaci and Herba Violae could be detected by TLC. The linear range of Baicalin was 0.08～2.49 ?g(r=0.999 9). The average recovery rate was 100.24%(RSD=1.52%,n=6).CONCLUSION: The establish criteria are suitable for the quality control of Xiaoyan tablets.

Quality Criteria of Kesuting Oral Liquid / 中国药房

OBJECTIVE:To establish the quality criteria of Kesuting oral liquid. METHODS: Qualitative identification of Herba Ephedrae,Folium Mori and Radix Et Rhizoma Glycyrrhizae was conducted using TLC method. The content of Baicalin was determined by HPLC in which the chromatographic separation was performed on Spherigel ODS C18(250mm?4.6mm,5?m) column with mobile phase consisted of methanol-0.4%phosphate solvent(52∶48) at a flow rate of 1.0 mL?min-1. The UV wavelength was set at 280 nm. RESULTS: The TLC spots of Herba Ephedrae,Folium Mori and Radix Et Rhizoma Glycyrrhizae were characteristic and obvious, and which can be used for qualitative identification. The linear range of Baicalin was 0.24～1.20 ?g (r=0.999 8) with a mean recovery rate of 98.72%(RSD=1.02%,n=6). CONCLUSION:The establish criteria are suitable for the quality control of Kesuting oral liquid.

Study on Quality Criteria of Fever and Cough Syrup for Children / 中国药房

OBJECTIVE:To establish the quality criteria of fever and cough syrup for children.METHODS:Thin-layer chromatography(TLC) was employed to make qualitative determination of herbba ephedrae,radix scutellariae,radix glycyrrhi-zae in fever and cough syrup for children,and high performance liquid chromatography(HPLC) was used to determine the con-tent of amygdaloside in its chief medicinal material,almond.RESULTS:The spots in the TLC of herbba ephedrae,radix scute-llariae,radix glycyrrhizae were in the same color with those in the chromatograms of control articles.The linear range of amygdaloside was 0.198?g～4.954?g(r=1.0 000).CONCLUSION:The present method is simple,accurate sensitiveness and highly reproductive,which can be used for the quality control of this preparation.