Frequently Relapsing Secondary Cutaneous Diffuse Large B-cell Lymphoma in the Skin / 대한피부과학회지

We report a case of cutaneous diffuse large B cell lymphoma in a 66-year-old male who had a 5-year history of diffuse large B cell lymphoma on the left inguinal lymph node. The patient visited our clinic for the first time for relief of a non-tender well-defined erythematous hard nodules on the left foot and left thigh that had been present form 6 months and 1 month, respectively. Histologic examination revealed diffuse dense infiltration of large neoplastic lymphocytes with scanty cytoplasm and large nuclei. They showed a positive reaction to CD20 and CD79a, suggesting a B cell lineage. The patient was diagnosed with secondary cutaneous diffuse large B cell lymphoma. After 1 month of radiation therapy, complete remission was achieved. Five and seven months later, the patient returned foe relief of non-tender red-to-brown hard nodules on the left and right thigh, respectively. Histologic examination and immunohistochemical stain prompted the same diagnosis as previously. After radiotherapy and chemotherapy, the skin lesion was nearly resolved, and no evidence of extracutaneous involvement has been noted since.

A Case of Secondary Cutaneous Diffuse Large B-cell Lymphoma / 대한피부과학회지

Cutaneous, diffuse, large B-cell lymphoma (DLBCL) is characterized by a diffuse dermal infiltration which is composed of large centroblasts and immunoblasts. It is subdivided into a primary form arising from the skin and a secondary form which is metastasized from the lymph node. Secondary DLBCL has a more aggressive clinical course than the primary form. We report a 39-year-old female patient who presented with a 2 cm sized, erythematous, subcutaneous nodule on her left upper arm. She had been treated for brain-diffuse, large B-cell lymphoma which occurred 5 years before. The histopathologic and immunohistochemical examinations of the skin lesion also showed diffuse, large, B-cell lymphoma.

A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma

We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.

A Case of Secondary Cutaneous Diffuse Large B-cell Lymphoma

We herein report a case of secondary cutaneous diffuse large B-cell lymphoma(DLBCL) occurring in a 66-year-old woman. The skin lesions were erythematous infiltrative nodules on the right inguinal area. Histologically, the skin lesion disclosed DLBCL mainly composed of immunoblasts. Concurrently, she showed lymph node involvement. Initially, however, we could not define the conclusive temporal sequences between nodal lesions and skin lesions. Finally, additional further studies revealed this case as secondary cutaneous 8-cell lymphoma, and she was managed with systemic chemotherapy.