ABSTRACT
Objective:To discuss the curative effect of phosphocreatine adjuvant treatment on neonatal hypoxic -ischemic myocardi-al lesion and its influence on serum IL-6 and myocardial enzyme .Methods:Totally 80 cases of newborns with hypoxic-ischemic myo-cardial lesion were divided into the observation group and the control group at random .The two groups were given the routine medical treatment, including maintenance of ventilation , warmth, water-electrolyte and acid-base balance, heart rate, blood pressure, nutrition support and etc, while the newborns in the control group were additionally given 250 mg· kg-1 1,6 diphosphate (FDP), ivgtt bid, for 10 days, while those in the observation group , were additionally given 1.0g phosphocreatine dissolved in 100 ml 0.9% normal saline (NS) on the basis of the treatment of the control group , ivgtt qd, for 10 days.The clinical curative effect and security were observed and the changes of serum IL-6 and myocardial enzyme in the two groups were compared .Results: The levels of LDH, CK, CK-MB and serum IL-6 in the two groups were obviously declined when compared with those before the treatment (P<0.05 or P<0.01), and the declining rate of the observation group was higher than that of the control group (P<0.05).The total clinical efficiency of the ob-servation group was higher than that in the control group after the medical treatment (P<0.05), and no serious untoward effect ap-peared in the two groups during the medical treatment .Conclusion: Phosphocreatine has significant curative effect on neonatal hy-poxic-ischemic myocardial lesion , which can effectively improve myocardial function of newborns and reduce myocardial enzyme and se -rum IL-6 levels.
ABSTRACT
BACKGROUND/AIMS: Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resecwas to clarify the clinical significance of IL-6, VEGF, CRP before ESD. METHODS: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers). RESULTS: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05). Especially, serum IL-6 level of high-grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients, and the positive rate, sensitivity, and negative predictive value of serum IL-6 levels were higher in high-grade dysplasia patient compared to low-grade dysplasia patient and mucosal cancer patient. Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01). Serum levels of CRP in patients with mucosal cancer were significantly higher than in the controls (p<0.05), and the positive rate, sensitivity, and positive predictive value of serum CRP levels were higher in high-grade dysplasia and mucosal cancer patients compared to low-grade dysplasia patient. CONCLUSIONS: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients.