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Background: Wide variation in the lipid profile in pregnancy is quite common. Exaggerated changes in insulin and lipid levels in women with GDM during pregnancy, lead to significant alterations in lipid levels in comparison to normal pregnancy. Lipid metabolism during pregnancy has a significant role to play in the aetiology and pathogenesis of GDM as is indicated by various studies previously.Methods: A hospital-based case control study was conducted at Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha in the Department of Endocrinology. The sample size was 100 pregnant women. Study period was of one year from June 2018 to June 2019. In women of both the groups, i.e., with GDM and without GDM the mean age of presentation were 20-25 yrs. Out of the 100 cases, we took 50 patients of GDM in the cases group and 50 patients of non GDM pregnant women as control group. Fasting lipid profile was sent to the hospital laboratory analyzed by Tinder’s methods. The results thus obtained were analyzed using student ‘t’ test for statistical significance using SPSS version 20.Results: There was no statistical difference in age and parity between control and case group. Triglyceride (cases- 286.4±77.60 mg/dl) (controls-166±26mg/dl), total cholesterol (cases-256.5±41.7 mg/dl) (controls - 202.5±20.18mg/dl), VLDL (cases-53.4±13.2 mg/dl) (controls-46.6±13.1mg/dl) showed statistically significant values (p value<0.001). HDL and LDL values did not show any statistical significance (p value >0.5) among GDM and non GDM group. Lipid profile was performed predominately in women in II trimester.Conclusions: In comparison to non GDM women, it was observed that serum triglyceride, total cholesterol and VLDL level are significantly higher in woman with GDM. Whether lipid profile can be used as a predictor for gestational diabetes mellitus in future needs further research.
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Background: Dyslipidemia is one of the common disorders which is seen in most of the diabetes patients, which causes cardio vascular disorders. Objective: To detect the lipid abnormality in diabetic patients. Methods: The study was carried out at Medicine Department, K.J. Mehta hospital, Amargadh, Bhavnagar during period from September 2014 to August 2015. The lipid profiles and the fasting blood sugar values of 100 type-1 diabetic patients, 100 type-2 diabetic patients and 50 healthy subjects were studied after taking informed consent. Their serum samples were assessed for fasting blood glucose (FBG), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL) and high density lipoprotein cholesterol (HDL) by using standard biochemical methods. The data was collected by predesign, pretested proforma and analyzed using SPSS 17.0 (Trial version). Results: Maximum Number of patients (37% and 44%) were from age group of 20-29 years in type-1 DM & 50-59 years in type-2 DM respectively. 53% cases of type-1 DM and 70 % cases of type-2 DM had less than 140 mg/dl level of Fasting Blood Sugar (FBS. 49 % patients of type-1 DM and 30% of type-2 showed more than 200 mg/dl level of Post Prandial Blood Sugar (PPBS). Majority of type 2 DM patients (72%) showed high serum cholesterol level, while only 12% of the type1 DM patients showed high serum cholesterol level. 95% of type 1 DM patients showed normal (10-190 mg/dl) serum triglyceride level, while only 26% of type 2 DM subjects showed normal level. Serum LDL level was high (>160 mg/dl) in 78% of type 2 DM patients, while only 19% of type 1 DM patients showed higher value. All patients of type 2 had normal serum HDL level. Conclusions: The frequencies of the high cholesterol, high TG and high LDL levels were higher in the diabetic group, thus indicating that diabetic patients were more prone for dyslipidemia, which could cause cardiovascular disorders.
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<b>Objective:</b> Hypertriglyceridemia or elevated serum triglyceride (TG) is a leading risk factor for developing atherosclerotic cardiovascular diseases.This clinical study was designed to test the potential of polyphenol-rich extract from <i>Rosa rugosa</i> petals (PE) for improving hypertriglyceridemia and other types of dyslipidemia. <b>Methods:</b> An open-label clinical study was conducted on 19 male and female adult subjects with elevated serum TG (120–399 mg/dL), who were intervened the study diet containing (in a daily dose) 200 mg of PE once daily for sss4 weeks.The serum levels of TG and cholesterols were measured at baseline and week-4.The efficacy was evaluated by comparing the measurements at these two timepoints. <b>Results:</b> A significant decrease (P < 0.05) in serum TG, as well as in serum total cholesterol and non HDL-cholesterol, and a marginally significant decrease (P = 0.070) in serum LDL-cholesterol were observed, while serum HDL-cholesterol was virtually not changed.The study diet was well tolerated without any untoward side effect. <b>Conclusions:</b> The PE-containing diet appears to have benefits in improving hypertriglyceridemia and hypercholesterolemia.
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The purpose of this study was to measure serum lipids concentrations by gender and age, and to investigated the relation of serum lipids levels to cigarette smoking alcohol intake exercise and menopausal status in Korean adults. The subjects consisted of 463 healthy adult(29- men and 173 women) volunteers who were visiting the health Promotion Center in the Asan Medical Center from July 1, 1994 to July 22, 1994 Subjects were ambulatory free-living people and aged 20- 80 years, Anthropometric measurement was performed and serum triglyceride(TG), HDL-cholesterol and total cholesterol(TChol) concentrations were measure by automatic system(Hitachi 736-40). Data on life styles were obtained using structured questionnaires issued by a trained interviewer, All data were statistically analyzed by PC-SAS(Version 6.04) Serum concentrations of triglyceride and total cholesterol was higher(p170 mg/dL and TChol>220 mg /dL) was 12.5% in men and 4.1% in women. The levels of serum triglyceride, total cholesterol and BMI increased with age in women. The distribution curves of serum triglyceride, total cholesterol and LDL-cholesterol of women were located in lower increased more rapidly with aging than in men, The distribution curves of BMI of women increased with aging after the thirties, The BMI of women was located in higher levels than of men in their sixties. The serum concentration of triglyceride and total cholesterol of male current-smokers and non-smokers were significantly(p<0.05) higher than those of ex-smokers. The concentrations triglyceride the male current0drinkers were higher(p<0.05) than those of male non-drinkers. In non-smokers and non-drinkers, serum TG concentration were lower (p<0.05) than those of current-smokers and current-drinkers. In exercisers, the serum triglyceride concentration was significantly(p<0.05) lower than in non-exercisers. In postmenopausal woman BMI and serum concentrations of TChol, TG and LDL-Chol were significantly by age and gender and smoking alcohol drinking, exercise and menopausal staus might be a better indicator to predict serum lipids in both genders.
Subject(s)
Adult , Female , Humans , Male , Aging , Alcohol Drinking , Cholesterol , Health Promotion , Life Style , Menopause , Obesity , Prevalence , Surveys and Questionnaires , Smoke , Smoking , Triglycerides , VolunteersABSTRACT
In this study, the effect of Rhizoma Alismatis on experimentel fat rat caused by monosodium glutamate which was injected hypodermically at large doses into fant rats has been observed.The conclusion of experiment shows that the rat weight increased, the Lee exponent value was obviously larger than that of control group, the fat in body was accumulated in abundance and the content of serum triglyceride markedly rose after 10 weeks when monosodium glutamate was injected. The Rhizoma Alismatis can reduce Lee exponent value of fat mice, fat exponent and serum triglyceride content in periphery of uterus and testis, which suggested that it possessed a certain action against fat.