ABSTRACT
Objective: To observe the clinical efficacy of Tuina (Chinese therapeutic massage) plus Shen Ling Bai Zhu San for pediatric diarrhea due to spleen deficiency.Methods: A total of 105 children with diarrhea due to spleen deficiency were selected and randomized into two groups by the random number table method. Fifty-two cases in the control group were treated with oral Shen Ling Bai Zhu San, and 53 cases in the observation group were treated with additional Tuina treatment. The clinical efficacy was evaluated after treatment, and the changes of traditional Chinese medicine (TCM) symptom scores were observed. Results: During the trial, there were three dropouts in the observation group, and two in the control group. After the treatment, the total effective rate was 100.0％ in the observation group, and 90.0％ in the control group. The difference between the two groups was statistically significant (P<0.05). The scores of primary and secondary symptoms, and the total scores of TCM symptoms in both groups were significantly lower than those before treatment (P<0.05). And the scores of primary and secondary symptoms, and the total score of TCM symptoms in the observation group after treatment were lower than those in the control group (P<0.05). There were no obvious adverse reactions in either group during the treatment. Conclusion: Tuina plus Shen Ling Bai Zhu San has a better therapeutic effect in treating pediatric diarrhea due to spleen deficiency than Shen Ling Bai Zhu San alone.
ABSTRACT
Objective To investigate the effect of Shenling-Baizhu powder on gastrointestinal hormone,digestive enzyme and inflammatory factors in D-IBS rats.Methods A total of 50 Wistar rats were randomly divided into the normal group,the model group,the Shenling-Baizhu powder large dose group,medium dose group and small dose group,10 rats in each group.D-IBS rat model was induced by high lactose diet and restraint stress except normal group.At the same time,the Shenling-Baizhu powder groups received Shenling-Baizhu powder (large dose group:9 g/kg,medium dose group:3 g/kg,small dose group:1 g/kg),normal group and model group received equal volume of normal saline.Malate dehydrogenase (MDH),lactate dehydrogenase (LDH) and disaccharidase activities were detected from small intestine of rats in each group.Plasma vasoactive intestinal peptide (VIP) and substance P (SP) activities were measured by radioimmunoassay.TNF-α and IL-10 levels in serum were determined by ELISA.Results Compared with the model group,the model group,the ratio of serum TNF-α/IL-10 (0.31 ± 0.15,0.34 ± 0.21,0.41 ± 0.15 vs.0.74 ± 0.19) significantly decreased in large,medium and low dose groups (P＜0.05).The disaccharidase activities in the small intestinal mucosa (38.44 ± 11.30 U/mg,44.77 ± 16.46 U/mg,42.58 ± 13.02 U/mg vs.23.23 ± 6.85 U/mg) significantly increased in the large,medium and low dose groups (P＜0.05).LDH activities in the small intestinal mucosa (1 863.61 ± 1 019.28 U/mg,1 136.13 ± 631.89 U/mg vs.416.50 ± 223.94U/mg) significantly increased in large,medium dose groups (P＜0.05).Plasma SP level (22.88 ± 10.17 pg/mg vs.31.86 ± 7.81 pg/mg) significantly decreased in large dose group (P＜0.05).Conclusions Shenling-Baizhu powder may increase the activities of LDH,MDH and disaccharidase,inhibit the abnormal secretion of SP and regulate of Th1/Th2 immune imbalance to relieve diarrhea.