ABSTRACT
Introduction: In today’s world, infertility is one of themajor emerging health issues which effects about 8-9% ofreproductive age group. Infertility due to certain male factorsand complete tubal obstruction may require interventionalprocedure. Increased risk of adverse perinatal outcomes areassociated with ART. Study objctive was to asses perinataloutcome in pregnant women conceived with inventionaltechniques.Material and Methods: A Retrospective study was done attertiary care hospital from January 2018 to June 2018. anddata was collected. The maternal and fetal condition werenoted as per records.Results: Women > 40 years of age had 11.53% of intrauterinedeath, 65.38% requires NICU admission, 11.53% requiresventilator support and 7.69% had neonatal death.Study alsorevealed foetal complications like intra uterine death (pvalue=0.0004), fetal anomalies, IUGR (P value=0.0003)which were atleast four times more in ART group than inspontaneous conception.Study also revealed that out of 167new born in ART group,there were 28.74% having verylow birth weight,19.76% were having low birth weight and51.50% had adequate weight, i.e around half of them werehaving weight less than 2 kgs as compared to spontaneouspregnancy group were only 5.71% i.e 6 babies were born lessthan 2 kg weight(P value < .0001 highly significant).Conclusion: Maternal age was significantly associatedwith perinatal and obstetrical complications. To improvematernal and perinatal outcomes, pre-existing diseases likehypertension, anaemia, diabetes mellitus and hypothyroidismshould be treated before conception. Overall aim should beto minimize iatrogenic preterm birth for minor ailments,close supervision of such women can add few more weeks topregnancy thus improving neonatal outcome.
ABSTRACT
OBJECTIVE: To identify cytogenetic diversity of Turner syndrome, and its correlation with clinical manifestation including fertility. METHOD: From 1986 to 1996, we reviewed medical records of 137 patients, cytogenetically and clinically diagnosed as Turner syndrome. Cytogenetic study was performed using peripheral lymphocytes with GTG banding. Marker chromosomes were re-evaluated by quinacrine staining. RESULTS: Overall incidence of mosaic pattern was 57.7% in Turner syndrome, showing 45,X line combined with structural anomalies of X chromosome(n=39), marker chromosome(n=22), numerical abnormalities of sex chromosome(n=6), and 46,XX(n=5). With comparison of clinical manifestation in 45,X/46,XX(n=5) and four most common pattern, 45,X(n=42), 45,X/46,X,i(Xq)(n=26), 45,X/46,X,+mar(n=22), 46,X,i(Xq)(n=9), there was no significant differences statistically, except short stature and diabetes. Incidence of short stature was significantly higher in 45,X or 46,X,i(Xq) than 45,X/46,XX(78.6%, 88.9%, 20.0%), and significant difference existed in incidence of diabetes between 45,X and 46,X,i(Xq)(0%, 22.2%). Sixteen patients had a history of marriage, but only one had a history of spontaneous conception and delivery with mosaic 45,X[2]/51,XXXXXXX[1]/46,XX[47]. CONCLUSION: The karyotypes of Turner syndrome was very variable, and about 60% had mosaicism. Patients with 45,X/46,XX had a significant lower incidence of short stature than in 45,X or 46,X,i(Xq), and 46,X,i(Xq) had a significant higher incidence of diabetes than in 45,X. We identified a woman with mosaic 45,X/51,XXXXXXX/46,XX was fertile.