Matrix formulation optimizing of Periplaneta americana Cream by D-optimal mixture design / 中草药

Objective: To optimize the matrix formulation of Periplaneta americana Cream. Methods: To optimize the blank matrix formulation by D-optimal mixture design, using presentation, spread property, centrifugal stability, cold stability, and thermostability as evaluating indicators, and to investigate the dosage of P. americana extract. Results: The matrix formulation of P. americana Cream was as follows: glycerol 11.00 g, stearic acid 14.00 g, triethanolamine 3.50 g, atolein 18.00 g, petrolin 10.00 g, water 43.50 g, and the amount of P. Americana extract 1.0 g. Conclusion: D-optimal mixture design is an effective and systematic method which could optimize the matrix formulation to reach the optimum presentation and physical property.