ABSTRACT
Secretory phospholipase A2 group II A is an enzyme that hydrolyzes the sn-2 ester in glyceroacyl phospholipids present in lipoproteins and cell membranes. There have been an increasing number of reports regarding the pathogenesis of the enzyme in cardiovascular,tumor and autoimmune diseases in recent years and drug development targeting the enzyme is receiving more and more attention as a result. This article reviews research results in the above areas and current status of drug development based on reported sPLA2-II inhibitors.
ABSTRACT
The species of genus Iris L. (Iridaceae) have a long history of traditional medicinal use in many places around the world, and are used in the treatment of cancer, inflammation, bacterial and viral infections. The plants in Iris L. have been previously recognized, in which flavonoids are found predominantly. During the last five years, 118 flavonoid constituents have been discovered and characterized, including 18 new compounds, from 19 species of Iris L. The details of their source, structural feature, biological activity as well as its mechanism are given in this review.