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Objective To explore the CT characteristics of primary pulmonary synovial sarcoma (PPSS)to improve the understanding of the disease.Methods The clinical,imaging and pathological data of 5 patients with PPSS confirmed by operation and pathology was analyzed retrospectively.4 patients underwent enhanced CT scan,and 1 patient underwent plain CT scan.STY-SSX fusion genes of 3 patients were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).Results All the lesions were located in the upper lobe of the lung.Most lesions showed as round-like heterogeneous solid masses with clear edge,3 lesions showed heterogeneous enhancement,and 2 lesions showed circular enhancement with obviously enhanced parenchyma.1 lesion was with calcification,3 lesions were with ipsilateral pleural effusion,and mediastinal lymph nodes metastasis was seen in 1 case.The immunohistochemical results showed that the expressions of Vim,CD56,CD99,Bcl-2 and Ki-67 were positive.Only 1 case was EMA individually positive.SYT-SSX gene was detected in 3 cases.Conclusion The imaging findings of PPSS are relatively specific,the diagnosis mainly relies on pathological, immunohistochemical examination and SYT-SSX detection.
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Objective To explore the CT characteristics of primary pulmonary synovial sarcoma (PPSS)to improve the understanding of the disease.Methods The clinical,imaging and pathological data of 5 patients with PPSS confirmed by operation and pathology was analyzed retrospectively.4 patients underwent enhanced CT scan,and 1 patient underwent plain CT scan.STY-SSX fusion genes of 3 patients were detected by reverse transcriptase-polymerase chain reaction (RT-PCR).Results All the lesions were located in the upper lobe of the lung.Most lesions showed as round-like heterogeneous solid masses with clear edge,3 lesions showed heterogeneous enhancement,and 2 lesions showed circular enhancement with obviously enhanced parenchyma.1 lesion was with calcification,3 lesions were with ipsilateral pleural effusion,and mediastinal lymph nodes metastasis was seen in 1 case.The immunohistochemical results showed that the expressions of Vim,CD56,CD99,Bcl-2 and Ki-67 were positive.Only 1 case was EMA individually positive.SYT-SSX gene was detected in 3 cases.Conclusion The imaging findings of PPSS are relatively specific,the diagnosis mainly relies on pathological, immunohistochemical examination and SYT-SSX detection.
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Se presenta el caso clínico de un paciente ecuatoriano de 62 años, mestizo, con antecedente de orzuelos reiterados en el ojo izquierdo, atendido en la consulta de Oftalmología del Hospital del Tena, del Instituto Ecuatoriano de Seguridad Social de Ecuador, por presentar desde hacía 8 meses molestias en ese mismo ojo y presencia de una lesión en el párpado inferior que sangraba con facilidad, acompañado de dificultad al cierre palpebral, por lo cual se le realizó una resección quirúrgica de la lesión con biopsia incluida, cuyo resultado confirmó el diagnóstico de carcinoma epidermoide de la conjuntiva
The case report of a 62 years mixed race Ecuadorian patient, is presented with a history of repeated sties in the left eye, assisted in the Ophthalmology Service of Tena Hospital in the Social Security Ecuadorian Institute of Ecuador, due to discomfort in that same eye during 8 months and an injury in the lower lid with easy bleeding, accompanied by difficulty to the palpebral closing , reason why a surgical resection of the injury was carried out with biopsy which result confirmed the diagnosis of epidermoid carcinoma of the conjunctiva
Subject(s)
Carcinoma, Squamous Cell , Hordeolum , Conjunctiva , EyeABSTRACT
Objective To evaluate the effect of α-melanocyte stimulating hormone (α-MSH) and its novel analogue STY39 on the production of tissue factor pathway inhibitor (TFPI) in mice with endotoxemia.Methods Female BALB/c mice were randomly divided into eight groups with 9 mice in each group.Endotoxemia was reproduced by intraperitoneal injection of lipopolysaccharide (LPS,25 μg/kg) and D-galactosamine (D-Gal,100 mg/kg).The animals of the control group were given phosphate buffered solution (PBS) instead.In the experimental groups,the mice were injected intraperitoneally with 2.5 mg/kg α-MSH or STY39 at 1,2 or 3 hours following LPS injection.The orbital blood was collected at different time points,and tissues of lung,liver,and kidney were collected 8 hours after the administration of LPS.The plasma TFPI levels were determined by enzyme linked immunosorbent assay (ELISA),and the expression of TFPI mRNA in different tissues was determined with reverse transcription-polymerase chain reaction (RT-PCR).Results The plasma TFPI levels (μg/L) began to increase (11.84 ± 1.55) in the endotoxemia mice 4 hours after LPS challenge and reached the peak (23.49 ± 1.12) at 8 hours.α-MSH or STY39 treatment at 1,2 or 3 hours after LPS challenge could significantly increase the TFPI content,with the best drug effect at 1 hour after LPS challenge (the blood was collected 8 hours after LPS challenge,α-MSH group:58.79 ± 2.67 vs.28.49 ± 1.69,STY39 group:71.08 ± 2.13 vs.28.49 ± 1.69,both P＜0.01),and the effect of STY39 was better than that of α-MSH (P＜0.01).A small amount of TFPI mRNA expression was observed in each tissue of the healthy mice.After LPS challenge,TFPI mRNA expression was increased in all the tissues,especially in the lung,liver and kidney.α-MSH or STY39treatment at 1 hour after LPS challenge could significantly up-regulate the expression of TFPI mRNA in the lung and liver (A value,α-MSH in lung:51.10 ±2.89 vs.32.43 ±2.51,STY39 in lung:72.11 ±3.48 vs.32.43 ±2.51;α-MSH in liver:43.21 ± 2.12 vs.29.29 ± 2.06,STY39 in liver:66.82 ± 1.76 vs.29.29 ± 2.06,both P＜0.01).The treatment with STY39 at 1 hour after LPS challenge could significantly up-regulate the expression of TFPI mRNA in the kidney (A value:45.21 ± 1.80 vs.30.44 ± 2.23,P＜0.01),but the treatment with α-MSH had no obvious effect (A value:24.61 ± 1.98 vs.30.44 ± 2.23,P＞0.05).The enhancing effect of early administration of STY39 on TTPI mRNA expression in the lung,liver and kidney tissues of endotoxemia mice was more powerful than that of α-MSH (all P＜0.01).Conclusion The early administration of α-MSH or STY39 may up-regulate TFPI production in the mice with endotoxemia,and the effect of STY39 is superior to α-MSH.