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Objective To compare the effects of alone and combined administration of nalbuphine and sufen-tanyl for patient-controlled intravenous analgesia ( PCIA) after caesarean section.Methods From June 2017 to December 2017,90 women undergoing cesarean section in the Sixth Hospital Affiliated to Shanxi Medical University were selected.They were divided into three groups (with 30 cases in each group) using a random number table :sufent-anyl 1.5μg／kg group (group S),nalbuphine 2.0mg／kg group ( group N) and nalbuphine 1.0mg／kg+sufentanyl 1μg／kg group (group NS).In each group tropisetron 6 mg was added,and PCIA solution was then diluted to 10mL in normal saline.Postoperative vital signs, visual analogue scale ( VAS) score, the highest Ramsay sedation score , number of self-control analgesia and the occurrence of side effects within 24h after operation were recorded. Results The highest VAS score within 24h after surgery had statistically significant difference among the three groups [group N (2.66 ±1.09)points ＞group S (1.45 ±0.57) points ＞group NS (0.90 ±0.55) points] ( F＝40.11,P＜0.05).The Ramsay sedation score among the three groups had no statistically significant difference [group S (2.34 ±0.61)points,group N (3.13 ±0.63)points,group NS (2.60 ±0.72)points] (F＝11.00,P＞0.05).The number of controlled analgesia among the three groups had no statistically significant difference [ group S (0.76 ± 0.69),group N (2.93 ±0.87),group NS (0.54 ±0.57)] (F＝101.11,P＞0.05).The incidence rates of adverse reactions of the three groups were 26.66%(8／30),16.67%(5／30) and 6.66%(2／30),respecyively,the difference was not statistically significant (P＞0.05).Conclusion Combination of nalbuphine and sufentanyl has more signifi-cant effect of PCIA after cesarean section than either of the drugs use alone ,which is worthy of clinical promotion.
ABSTRACT
Objective@#To compare the effects of alone and combined administration of nalbuphine and sufentanyl for patient-controlled intravenous analgesia (PCIA) after caesarean section.@*Methods@#From June 2017 to December 2017, 90 women undergoing cesarean section in the Sixth Hospital Affiliated to Shanxi Medical University were selected.They were divided into three groups(with 30 cases in each group) using a random number table: sufentanyl 1.5μg/kg group (group S), nalbuphine 2.0mg/kg group (group N) and nalbuphine 1.0mg/kg+ sufentanyl 1μg/kg group (group NS). In each group tropisetron 6 mg was added, and PCIA solution was then diluted to 10mL in normal saline.Postoperative vital signs, visual analogue scale (VAS) score, the highest Ramsay sedation score, number of self-control analgesia and the occurrence of side effects within 24h after operation were recorded.@*Results@#The highest VAS score within 24h after surgery had statistically significant difference among the three groups [group N (2.66±1.09)points > group S (1.45±0.57)points > group NS (0.90±0.55)points](F=40.11, P<0.05). The Ramsay sedation score among the three groups had no statistically significant difference [group S (2.34±0.61)points, group N (3.13±0.63)points, group NS (2.60±0.72)points] (F=11.00, P>0.05). The number of controlled analgesia among the three groups had no statistically significant difference [group S (0.76±0.69), group N (2.93±0.87), group NS (0.54±0.57)] (F=101.11, P>0.05). The incidence rates of adverse reactions of the three groups were 26.66%(8/30), 16.67%(5/30) and 6.66%(2/30), respecyively, the difference was not statistically significant (P>0.05).@*Conclusion@#Combination of nalbuphine and sufentanyl has more significant effect of PCIA after cesarean section than either of the drugs use alone, which is worthy of clinical promotion.
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Objective To explore effect of eptazocine hydrobromide combined with sufentanil on postoperative analgesia after trans-urethral resection prostate ( TURP ). Methods One hundred and twenty adult patients undergoing TURP were randomly divided into three groups ( n＝40): eptazocine hydrobromide group ( group E), dezocine combined with sufentanyl group (group DS) and eptazocine hydrobromide combined with sufentanyl group (group ES).All patients received postoperative patient controlled intravenous analgesia (PCIA).The patients in the group E were given eptazocine hydrobromide with dose of 1 mg·kg-1;group DS patients were given with dezocine of 0. 3 mg·kg-1combined with sufentanil 1. 5 μg·kg-1;group ES patients were given eptazocine hydrobromide 0.2 mg·kg-1combined with sufentanil 1.5 μg·kg-1.The VAS scores and Ramsay scores were recorded at 1 h (t1), 4 h (t2),8 h (t3), 12 h (t4), 24 h (t5) and 48 h (t6) postoperatively.Total analgesic consumption of PCIA pump and total need of remedial drugs, the incidences of postoperative dizziness, nausea and vomiting, and other adverse reactions during postoperative 48 h were also documented. Results Compared with group E, VAS scores at each time point postoperatively in group DS and group ES were lower (P<0.05);and total analgesic consumption of PCIA pump and total need of remedial drugs were also lower than group E(P<0.05);the incidence of vertigo, nausea and vomiting, dysphoria, drowsiness in group DS were higher(P<0.05);while only the incidence of nausea and vomiting in group ES was higher than group E (P<0.05).Compared with group DS, no statistical significances of VAS scores were found at each time point postoperatively between group DS and group ES (P>0.05);but total analgesic consumption of PCIA pump and the need of remedial drugs in group ES were lower (P<0.05);patients in group ES with lower incidence of respiratory depression, vertigo, dysphoria and drowsiness ( P< 0. 05 ). No statistical significances were found when comparing the Ramsay scores at each time point postoperatively among three groups (P>0.05). Conclusion Eptazocine hydrobromide combined with sufentanyl can effectively alleviate the postoperative pain in patients with TURP, reduce the consumption of postoperative analgesics and incidence of analgesic related adverse reactions.
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Objective To observe the effects of continuous injection sedation and target controlled infusion (TCI) sedation with midazolam and sulfentanyl for mechanical ventilation of ICU patients.Methods 62 mechanical ventilation patients were randomly divided into continuous group(n =31) and TCI group.Continuous group was given sedation with midazolam and sulfentanyl by continuous pumping.Sedation with fentanyl and midazolam pumping was adjusted to keep SAS scores of 3-4 points and bispectral index (BSI) of 70-75 in TCI group.The sedation span,sedative consumption and vital signs were measured andrecorded.Results Compared with continuous group,the consumption of midazolam [(1.29 ± 0.4) mg· kg-1 · 24h-1] and sulfentanyl [(16.9 ± 4.3) μg · kg-1 · 24h-1] in TCI group was significantly lower (t =2.875,2.593,all P ＜ 0.05).There was no significant difference in sedation span between TCI group (92.7 ± 15.1) h and continuous group (94.2 ± 16.3) h (t =0.293 P ＞ 0.05).Sedation satisfaction degree (62％) and human adaptation degree(87％) in TCI group were significantly higher than continuous group(x2 =3.883,2.204,all P ＜ 0.05).After sedative administration,HR,MAP and SpO2 did not significantly decrease compared with baseline.Conclusion TCI sedation can significantly decrease sedative administration of midazolam and sulfentanyl and increase human adaptation degree for mechanical ventilation ICU patients.TCI sedation could be a safe and effective sedation administration.
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Objective To evaluate the effects of different sequences of intravenous administration on sufenta-nyl-induced cough during induction of general anesthesia.Methods One hundred patients,aged 20 ~60 years,weig-hing 45 ~82 kg,ASA Ⅰ or Ⅱ,scheduled for elective surgery under general anesthesia,were equally randomized to two groups by using a random number table:sufentanyl-propofol group(group SP)and propofol-sufentanyl group(group PS).In group SP,sufentanyl 0.4μg/kg was injected intravenously over 5s,and then propofol 2mg/kg was injected intravenously.In group PS,propofol 2mg/kg was injected intravenously,and then sufentanyl 0.4μg/kg was injected intravenously over 5s.The occurrence,intensity and the time of cough were recorded within 1 min after sufentanyl injection.Results The incidence of cough was 38%(19 /50)in group SP which was significantly higher than the 12%(6 /50)in group PS(χ2 =9.013,P 0.05).Conclusion Administration in the propofol-sufentanyl sequence can effectively reduce the occurrence of sufentanyl-induced cough as compared with that in the sufentanyl-propofol sequence during induction of general anesthesia.