Efficacy of pulmonary surfactant combined with caffeine citrate on neonatal respiratory distress syndrome treated with synchronized nasal intermittent positive pressure ventilation / 中国小儿急救医学

Objective@#To investigate the clinical effects of pulmonary surfactant(PS) combined with caffeine citrate on neonatal respiratory distress syndrome(NRDS) treated with synchronized nasal intermittent positive pressure ventilation(SNIPPV).@*Methods@#We collected and analyzed 99 neonates who were diagnosed with NRDS and required SNIPPV treatment from January 2016 to June 2019 in NICU of Shengjing Hospital of China Medical University.According to the different treatment, they were divided into PS+ citrate caffeine combination group and control group.The control group(53 neonates)was treated by PS alone.The combination group(46 neonates)was treated with PS combined with caffeine citrate.The indexes of ventilator time, the time of using oxygen, length of hospital stay and complications were compared between the two groups.@*Results@#The indexes of ventilator time, the time of using oxygen and length of hospital stay of combination group were significantly shorter than those of the control group.The differences were statistically significant(P<0.05). However, the incidences of ventilator associated pneumonia, gastrointestinal dysfunction, arrhythmia and other complications were not significantly different between the two groups(P>0.05).@*Conclusion@#PS combined with caffeine citrate in the treatment of NRDS with SNIPPV could effectively improve the pulmonary function of infants.It could improve the neonatal survival rate and reduce complications.It is worth to be recommended.

Analysis of the effectiveness of synchronized nasal intermittent positive pressure ventilation for neonatal respiratory failure / 中国小儿急救医学

Objective To investigate the clinical effect of synchronized nasal intermittent positive pressure ventilation (SNIPPV) in the treatment of neonatal respiratory failure. Methods The clinical data of 52 neonates with respiratory failure treated in our hospital from January 2016 to January 2018 were retrospec-tively analyzed. According to the different treatment methods,they were divided into observation group and control group,26 cases in each group. The children in the observation group were treated with SNIPPV,while those in the control group were treated with synchronized intermittent positive pressure ventilation (SIPPV). Clinical efficacy,changes of blood gas analysis results before and after treatment,oxygen consumption time and hospital stay,and complications were compared between the two groups. Results The respiratory rate and heart rate of the two groups improved after treatment,but there were no significant differences between the two groups(P＞0. 05,respectively). The total effective rate of the observation group was 88. 5%,while that of the control group was 92. 3%,there was no significant difference between the two groups(χ2=0. 221, P＞0. 05). The pH,PaO2,PaCO2and oxygen saturation levels of 24 h after treatment in two groups were im-proved (P＜0. 05,respectively),but there were no significant differences between the two groups (P＞0. 05, respectively). Compared with the control group,the oxygen consumption time and hospitalization time of the observation group were significantly shorter, and the differences were statistically significant ( P ＜0. 05, respectively). And the observation group had fewer complications of ventilator associated pneumonia. Conclusion The effect of SNIPPV in the treatment of neonatal respiratory failure is significant. It could shorten the time of oxygen consumption and hospitalization and reduce the complications. It is worth populari-zing SNIPPV mode assisted ventilation.

Clinical study of sequential therapy by synchronized nasal intermittent positive pressure ventilation for preterm infants with respiratory distress syndrome after extubation / 中华实用儿科临床杂志

Objective To assess the efficiency of synchronized nasal intermittent positive pressure ventilation (SNIPPV) as a transitional mode in treatment of neonatal respiratory distress syndrome (RDS) after extubation.Methods In this single-center and randomized controlled trial,preterm infants (gestational age less than 35 weeks)with RDS who received mechanical ventilation were randomly assigned to receive SNIPPV(33 cases) or NCPAP(34 cases) after extubation.Blood gas analysis,prevalence of extubation failure and complications were compared between the 2 groups.Results The Pa (O2) in SNIPPV group was significantly higher but the pa (CO2) was significantly lower than those in the NCPAP group at 3 h and 12 h after extubation respectively(all P ＜ 0.05).Infants treated with SNIPPV had a decreased incidence of hypoxemia,hyperbicarbonatemia and extubation failure compared with those of patients treated with NCPAP (all P ＜ 0.05).SNIPPV group had a decreased incidence of apnea (P =0.000),shorter duration of mechanical ventilation and oxygen treatment duration than those of NCPAP group (all P ＜ 0.05).Conclusions SNIPPV is superior to NCPAP in serving as a transitional mode after extubation for preterm infants with RDS,and should be used in preference after extubation.