ABSTRACT
Syringa oblata is a traditional Mongolian medicine mainly distributed in the Helan Mountains (the boundaries of Inner Mongolia and Ningxia, China) and the north of Yan Mountains (Aohan Qi, Inner Mongolia, China). It is clinically used to treat diseases caused by Heyi, such as heartache and heat pathogen in the heart. Phytochemical studies on S. oblata revealed the presence of iridoids, lignans, triterpenes, phenylpropanoids, phenylethanoids, and volatile components. Pharmacological investigations revealed a broad spectrum of bioactivities, such as antimicrobial, antioxidant, antiproliferative, and hepatoprotective effects. This article summarized the chemical components and pharmacological activities of S. oblata, providing a scientific rationale for its bioactive constituents, quality control, and utilization as an important medicine.
ABSTRACT
Objective To study the chemical constituents from the leaf of Syringa oblata. Methods The compounds was isolated by silica gel column chromatography and HPLC, and their structure were identified by spectral data analysis. Results A total of 35 compounds were isolated and identified as oleanolic acid (1), ursolic acid (2), betulinic acid (3), 1,3-benzodioxole-5-propanol (4), p-hydroxyl benzene propyl alcohol (5), p-hydroxyl benzene ethel alcohol (6), syringopicrogenin D (7), syringopicrogenin E (8), syringopicrogenin F (9), syringopicrogenin A (10), syringopicrogenin C (11), 3,4-dihydroxyl benzene ethel alcohol (12), syringobittergenin B (13), syringo-picrogenin B (14), grasshopper ketone (15), (7R,8S)-4,9,9’-trihydroxyl-3,3’-dimethoxyl-7,8- dihydrobenzofuran-1’-propylneolignan (16), lariciresinol (17), syringin (18), 3(Z)-enol glucoside (19), quercetin-3-O-β-D- glucopyranoside (20), (8E)-ligstroside (21), epipinoresinol-4-O-β-D-glucopyranoside (22), (8E)-ligstroside B (23), (8E)-ligstroside A (24), salidroside (25), 7-dehydrologanin (26), fliederoside B (27), syringopicroside B (28), oleoside dimethyl ester (29), lilacoside (30), syrigopicroside (31), oleuropein (32), (+)-lariciresinol-4-O-β-D-glucopyranoside (33), verbascoside (34), and (+)- epipinoresinol-4’-O-β-D-glucopyranoside (35). Conclusion Compounds 4, 5, 14-16, 19, 23, 24, 26, and 27 are isolated from S. oblata for the first time.
ABSTRACT
Objective: To study the chemical constituents from the leaves of Syringa oblata. Methods: The compound was isolated by silica gel column chromatography and HPLC, and its structure was elucidated by means of spectral analyses. Results: A new iridoid was isolated and identified as 1β, 3α-diethoxy-7-oxo-8β-methyl-1, 3, 4, 4a, 5, 6, 7, 7a-octahydro-cyclopenta [c] pyran-4β-carboxylic- p-hydroxyphenethyl ester (1). Conclusion: Compound 1 is a new compound, named syringopicrogenin F.