Research progress of transient receptor potential ion channels and psoriasis / 中国临床药理学与治疗学

The occurrence of psoriasis mainly involves abnormal cellular immune system and the abnormal proliferation and differentiation of keratinocytes. Recent studies have found that transient receptor potential (TRP) ion channels are related to the etiology of psoriasis and play an important role in the pathophysiological process of psoriasis. Using inhibitors or activators of partial TRP channels can improve or alleviate the symptoms of psoriasis, suggesting that partial TRP channels may be new targets for psoriasis treatment. This article mainly reviews the relationship between TRP channels and etiology of psoriasis, and the research advancement of TRP channels as treatment targets for psoriasis.

Role and mechanism of TRP ion channels in pruritus / 中国药理学通报

Pruritus is an unpleasant noxious sensation induced by a variety of causes. Although pruritus does not cause death directly, long-term chronic pruritus severely reduces the quality of life of patients. TRP (transient receptor potential ion channels) participate in the physiological process from the sensation to skin balance. A large number of studies have confirmed that many itch media are involved in signal transduction related to TRP ion channels. We review the difference between itch and pain, and the role and mechanism of TRP in itch, so as to provide new research targets for treatment of pruritus.