In vitro Cytotoxic Activity of New Triphenyltin (IV) Alkyl-isopropyl-di-thiocarbamate Compounds on Human Acute T-Lymphoblastic Cell Line.

Cancer is one of the leading causes of mortality and morbidity worldwide. Various new metal-based compounds including organotin (IV) compounds have been actively synthesised due to their good cytotoxicity in cancerous cells. In this study, we tested the cytotoxicity of new triphenyltin (IV) dithiocarbamate compounds (triphenyltin (IV) benzylisopropyldithiocarbamate, compound 1; triphenyltin (IV) methylisopropyldithiocarbamate, compound 2; and triphenyltin (IV) ethylisopropyldithiocarbamate, compound 3) on the human acute T-lymphoblastic cell line, Jurkat E6.1 by MTT assay at three periods of time. The triphenyltin (IV) methylisopropyldithiocarbamate compound showed the lowest IC50 values (0.03 μM) after 24 h of treatment on Jurkat E6.1 cell lines. The IC50 values obtained for the three compounds for 24 h of treatment were 0.18 μM, 0.03 μM, and 0.42 μM, respectively. Next, for 48 h and 72 h of treatment, the IC50 values were 0.15 μM, 0.18 μM, and 0.40 μM and 0.18 μM, 0.19 μM, and 0.41 μM, respectively. These tested compounds were found to give cytotoxic activity against Jurkat E6.1 cell lines at micromolar doses. Observation on morphological changes of Jurkat E6.1 cell lines treated with IC50 values at 24 h of treatment showed morphological changes such as cell shrinkage and membrane blebbing, characterising the mode of cell death as apoptosis. Thus, further studies on the specific mechanisms of action of these compounds in human cells should be carried out to elucidate their potential as anticancer agents.

Triorganotin as a compound with potential reproductive toxicity in mammals

Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

Signal transduction in trialkyltin compounds-induced tumor cell apoptosis mechanism trialkyltin compounds-induced tumor cell apoptosis / 中国药理学通报

Aim Organotin compounds are important organometallic chemicals with a variety of technical applications.Of these compounds,the trialkyltins,especially tributyltin,triphenyltin and trimethyltin,have been proved to have the distinct ability to induce tumor cell apoptosis and significant antitumor activity.They can induce tumor cell apoptosis through Fas receptor,mitochondrial,Ca 2+,MAPKs,p53,NF-?B and caspase/p38/ROS pathway.This paper reviewed recent progress in the studies on signal transduction in tumor cell apoptosis induced by trialkyltin compounds.