ABSTRACT
Objective To evaluate the efficacy of percutaneous drug penetration in the treatment of young patients with relapsed positive pulmonary tuberculosis. Methods From June 2013 to May 2016,eighty-four cases of with relapsed bacterias and pulmonary tuberculosis treated in Hebei Chest Hospital were enrolled in the study and were randomly divided into the observation group and the control group, 42 cases in each group. Both groups were treated with conventional anti tuberculosis drug 2HRZES/6HRE, the patients in the observation group were treated with ultrasound conductometric instrument and ultrasound conductive gel patch (isoniazid 0. 1 g) for 1 time /d,20 min each time. The course lasted for 3 months. Results At the end of 1,3 and 8 months treatment,the rates of sputum negative conversion in the observation group were 45. 24%( 19/42),66. 07%( 28/42), 92. 86%( 39/42), which were significantly higher than those of the control group ((23. 81%( 10/42), 40. 48%( 17/42), 73. 81%( 31/42 )), the difference between the two groups was statistically significant (x 2＝4. 27,5. 79,5. 49,P＜0. 05). At the end of the 8 months,the obvious absorption rate of the lesion was 94. 48%(38/42),and the control group was 69. 05%(29/42). The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). At the end of 8 months,the curative rate of the observation group was 90. 48%, while that of the control group was 64. 29%. The difference between the two groups was statistically significant (x 2＝5. 97,P＜0. 05). Conclusion Percutaneous drug penetration has good safety. Combined with systemic chemotherapy,it can improve the treatment effect of young patients with relapsed bacterias positive pulmonary tuberculosis,and is worthy of promotion.
ABSTRACT
Objective@#To investigate the effects of transrectal ultrasound conductance (TRUSC)-guided administration of traditional Chinese medicine on histological prostatitis in men with small-size BPH and low urinary tract symptoms (LUTS) after transurethral resection of the prostate (TURP).@*METHODS@#This study included 167 BPH patients without surgical contraindications. We randomized the patients into an experimental group (n = 84) and a control group (n = 83), with no statistically significant differences between the two groups in age, prostate volume, International Prostate Symptom Score (IPSS), and quality of life (QoL) (P >0.05). The patients of the experimental group received TRUSC-guided administration of traditional Chinese medicine, qd, for 7 days before TURP, while those of the control group underwent TURP only. After treatment, we compared the results of postoperative pathological examination of the prostate tissue, the histological grade of inflammation, IPSS, and QoL scores between the two groups of patients.@*RESULTS@#In the experimental group, there were 12 cases of non-inflammation (14.3%), 43 cases of mild inflammation (51.2%), 28 cases of moderate inflammation (33.3%), and 1 case of severe inflammation (1.2%), as compared with 8 cases of non-inflammation (9.6%), 28 cases of mild inflammation (33.7%), 45 cases of moderate inflammation (51.8%), and 2 cases of severe inflammation (2.4%) in the control group (P <0.05). Compared with the baseline, both the experimental and control groups showed significant improvement at 4 weeks after surgery in IPSS (22.20±4.14 vs 4.26±2.64 and 23.05±4.11 vs 7.02±4.15, P <0.05) and QoL scores (4.33±0.83 vs 1.25±1.64 and 4.25±0.91 vs 2.05±1.95, P <0.05).@*CONCLUSIONS@#TRUSC-guided administration of traditional Chinese medicine can significantly alleviate histological inflammation and improve QoL in men with small-size BPH and LUTS after TURP.