ABSTRACT
Objective To observe the clinical effect of small dose mifepristone combined with traditional Chinese medicine in the treatment of uterine gland disease.Methods 76 patients with uterine gland disease were selected,they were divided into the observation group(n =38) and control group(n =38) by using random number table method.The control group was treated with small dose of mifepristone,while the observation group was treated with small dose of mifepristone combined with traditional Chinese medicine.The clinical curative effects of the two groups were compared.Results After treatment,in the observation group,the pain degree of patients [(21.30 ± 6.70) points],influence activity level [(17.30 ± 12.00) points],activity loss [(1.80 ± 0.70) spots] and grades of dysmenorrheal [(0.60 ± 0.20) stages] were lower than those in the control group,the differences were statistically significant (t =5.645,7.023,4.932,3.994,all P ＜ 0.05).After treatment,in the observation group,the uterine volume [(56.20 ± 2.00) mm3],CA125 level [(32.10 ± 2.10) U/mL] were lower than those of the control group (t =4.024,4.413,all P ＜ 0.05).The incidence rate of adverse reaction of the observation group was 7.89％,which was significandy lower than that of the control group,the difference was statistically significant (x2 =14.757,P ＜ 0.05).The patients were followed up for 8 months,the recurrence rate of the observation group was 5.26％,which was lower than 26.32％ of the control group,the difference was statistically significant (x2 =16.678,P =0.000).The menstrual recovery ratio less than or equal to three months of the control group was 81.58％,which was signifi candy higher than 63.16％ of the control group,the difference was statistically significant (x2 =8.484,P =0.003).Conclusion In the treatment process of adenomyosis,the small dose of mifepristone combined with traditional Chinese medicine can alleviate the clinical symptoms,reduce the pain and reduce the volume of uterus,and it has less adverse reaction,safe and reliable,it is worth of clinical application.
ABSTRACT
The histology and the ultrastructure of the uterine glands of the lesser bushbaby (Galago senegalensis) were studied in six specimens (5 pregnant and one non pregnant) which were fixed partly with bouin's fixative and part with 2.5% glutaraldehyde in 0.1 M cacodylate buffer. An overview of the main results revealed uterine glands in the non-pregnant uterus are rudimentary and scarce within the mucosa. In early pregnancy (first trimester) the uterine glands profiles appear in clusters. In late stage pregnancy (third trimester) the uterine gland profiles appear opposite chorionic vesicles. In the later stages of gestation maternal glandular epithelium consisted mainly of simple columnar epithelium. The cells had abundant flattened cisternae of granular endoplasmic reticulum usually with an apical-basal orientation. Their nuclei had abundant euchromatin relative to the amount of heterochromatin. They also had a prominent Golgi apparatus quite characteristic of protein synthesizing cells. The basal plasmalemma was thrown into infoldings that have the effect of increasing the surface area across which nutrients could pass from the maternal circulation and are secreted by the cell as histiotrophe. Both physiologic hypertrophy and hyperplasia of the uterine glands are observed to occur with advancement of pregnancy.
La histología y ultraestructura de las glándulas uterinas de la gálago menor (Galago senegalensis) fueron estudiadas en seis ejemplares (5 preñadas y 1 no preñada). Una parte de las glándula se fijó con Bouin y otra con glutaraldehído al 2,5% en tampón cacodilato 0,1 M. Una visión general de los principales resultados reveló que las glándulas uterinas en el útero no gestante son rudimentarias y escasas dentro de la mucosa. Al principio de la preñez (primer trimestre) las glándulas uterinas aparecen en racimos. En la última etapa de la preñez (tercer trimestre) las glándulas uterinas aparecen opuestas a las vesículas coriónicas. En las últimas etapas de gestación el epitelio glandular materno consiste principalmente en epitelio cilíndrico simple. Las células tenían abundantes cisternas aplanadas en el retículo endoplásmico rugoso, por lo general con una orientación apico-basal. Sus núcleos tenían abundante eucromatina en relación con la cantidad de heterocromatina. También tenían un aparato de Golgi prominente bastante característico de células que sintetizan proteínas. El plasmalema basal fue rechazado en repliegues que psoeen el efecto de aumentar el área de superficie a través del cual los nutrientes podrían pasar desde la circulación materna y son secretadas por las célula como histiotrofo. Hipertrofia fisiológica e hiperplasia de las glándulas uterinas se observaron con el avance de la preñez.