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Aim: To determine the relationship between maternal serum 25(OH) D concentrations and development of preeclampsia.Study Design:A cross sectional comparative study.Place and Duration of Study:Department of Obstetrics and Gynaecology, University of Abuja Teaching Hospital, Abuja, between March 2016 and February 2017.Methodology: We included 55 women with preeclampsiaand 55 healthywomen. Data obtained includedsociodemographic characteristics, clothing style and duration of exposure to sun light. ELISA method was used for evaluation of serum vitamin D levels.Original Research Article Results:The prevalence of VD deficiency in the population was 15%, while 16.8% and 73% of the participants had insufficient and normal levels respectively. The prevalence of VD deficiency in women withpreeclampsia was 20.4% while that in healthy pregnant women was 9.4% (P=.19). The mean serum 25-OH-D level of women with pre-eclampsia was significantly lower than that of healthy women (34.5±14.9 vs. 43.5±15.1, P = .003). Preeclamptic women with vitamin D insufficiency delivered at a higher gestational age than those with vitamin D deficiency (37.67(2.77) weeks vs. 33.55(2.38) weeks respectively, P=.007). In the adjusted analysis of cases with vitamin D defficiency, the odds of developing preeclampsia was not statistically significant [odds ratio (OR) = 3.27, CI = 0.99-10.83,P=.05]. However, the odds of developing preeclampsia in women with Vitamin D insufficiency wasstatistically significant (OR = 3.20, CI = 1.02–10.06, = 0.046).Conclusion: In conclusion, an association between vitamin D deficiency and preeclampsia was not demonstrated in this study. The results however suggest that maternal vitamin D insufficiency in late pregnancy is an independent risk factor for preeclampsia.
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To evaluate the Vitamin D status in patients with pulmonary tuberculosis and normal healthy adults. Methods: Total of 48 subjects 24 (14 male and 10 female) newly diagnosed pulmonary tuberculosis and 24 (16 male and 8 female) healthy controls) was selected through non-probability purposive sampling according to inclusion and exclusion criteria. Result: Significant differences were observed for the obesity and smoking p-value 0.032 and 0.021 respectively. Chest x ray revealed cavitary in 9 (37.5%) of cases. Hemoglobin, RBC counts and Platelet counts revealed statistically significant difference between cases and controls. Conclusion: Patients with tuberculosis are significantly Vitamin D deficient as compared to normal individuals.
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OBJECTIVES: Although the number of laboratory workers is constantly increasing every year, few studies have been conducted on the health and nutritional status of these research workers. This study determined the health status of laboratory workers by analyzing their anthropometric indices, dietary life, vitamin D status and blood clinical indices. METHODS: The subjects consisted of 100 female laboratory workers. This study investigated their diet, anthropometric indices, vitamin D status and blood clinical indices. The subjects were divided into two groups according to their duration of working in a laboratory (<1 year,≥1 year). RESULTS: The average age and body mass index (BMI) of subjects were 23.18 years and 21.51 kg/m2, respectively Those subjects with over 1 year employment (≥1 year) had a significantly higher waist-hip ratio than that of the subjects with the less than 1 year employment (<1 year). The mean serum vitamin D level of all the subjects was 10.04 ng/mL, which is close to a level of vitamin D deficiency. There was a significantly higher average intake of calories in the over 1 year employment group as compared to that of the less than 1 year employment group. The frequency of eating sweet snacks was significantly higher for the over 1 year employment group. The correlation analysis showed a significant positive correlation between the serum 25-(OH)-vitamin D level and the time of exposure to sunlight, while dietary intake of vitamin D did not show correlation with the serum 25-(OH)-vitamin D level. However, the serum 25-(OH)-vitamin D level was also negatively correlated with both the percentage of body fat and visceral fat. CONCLUSIONS: Laboratory workers are a very high risk group in terms of their nutritional status of vitamin D. Therefore, they need greater time of exposure to sunlight as well as increasing their dietary consumption of vitamin D. In addition, it is important for laboratory worker to practice regular and balanced dietary habits in order to maintain a healthy life.
Subject(s)
Female , Humans , Adipose Tissue , Body Mass Index , Diet , Eating , Employment , Feeding Behavior , Intra-Abdominal Fat , Nutritional Status , Snacks , Sunlight , Vitamin D Deficiency , Vitamin D , Vitamins , Waist-Hip RatioABSTRACT
The relationship between vitamin D deficiency and idiopathic central precocious puberty (ICPP) has been recently documented. In this study, 280 girls diagnosed with ICPP and 188 normal puberty control girls of similar ages were enrolled and retrospectively studied. The ICPP group had significantly lower serum 25-hydroxyvitamin D (25[OH]D) levels than the control group. Furthermore, a nonlinear relationship was found between serum 25[OH]D and ICPP, and a cut-off point for serum 25[OH]D was found at 31.8 ng/ml for ICPP with and without adjusting the different confounding factors. Girls with serum 25[OH]D ≥ 31.8 ng/ml had a lower odds ratio (unadjusted: OR 0.36, 95% CI 0.15 to 0.83, P < 0.05; height and weight adjusted: OR 0.44, 95% CI 0.18 to 1.08, P = 0.072; BMI adjusted: OR 0.36, 95% CI 0.16 to 0.84, P < 0.05). The ICPP subjects with 25[OH]D deficiency had a higher body mass index (BMI) than the subjects from the two other subgroups. Correlation analysis showed that vitamin D level is correlated with BMI and some metabolic parameters in the ICPP group. Our study suggested that vitamin D status may be associated with ICPP risk and may have a threshold effect on ICPP.
Subject(s)
Child , Female , Humans , Body Mass Index , China , Linear Models , Logistic Models , Multivariate Analysis , Puberty, Precocious , Blood , Retrospective Studies , Vitamin D , Blood , Vitamin D Deficiency , EpidemiologyABSTRACT
La obesidad se relaciona con valores más bajos de 25-hidroxivitamina D [25 (OH)] en suero, pero no está claro si esta relación difiere según la raza u origen étnico. Este estudio examina la relación entre la 25 (OH)D en suero y el índice de masa corporal (IMC) según la raza y el origen étnico en 3 461 mujeres (1 291 de raza blanca, 1 189 de raza negra y 981 mujeres estadounidenses de origen mexicano) de 20 a 49 años de edad provenientes de la encuesta National Health and Nutrition Examination Survey (NHANES III, 1988-94). Se midieron los valores de 25 (OH)D en suero con un equipo de radioinmuno ensayo, mientras que el IMC se calculó a partir de la altura y el peso medidos. El IMC se relacionó negativamente con la 25(OH)D en suero en los tres grupos, pero la relación fue notablemente más fuerte en las mujeres de raza blanca que en las afroamericanas o en las de origen mexicano. El ajuste para las variables de confusión redujo estas diferencias en la fuerza de la relación pero no las eliminó. En conclusión, la relación entre 25 (OH)D en suero e IMC en mujeres adultas jóvenes varía según raza y origen étnico, y es más fuerte en las de raza blanca que en las de raza negra o estadounidenses de origen mexicano. Es necesario investigar mejor la base de esta variación.
Obesity has been linked to lower serum 25 hydroxyvitaminD [25(OH)D] values, but whether this relationship differsby race/ethnicity is not clear. This study examines therelationship between serum 25(OH)D and body massindex (BMI) by race and ethnicity in 3 461 women (1 291non-Hispanic whites, 1 189 non-Hispanic blacks, 981Mexican Americans) ages 20-49 years from the thirdNational Health and Nutrition Examination Survey(NHANES III, 1988-94). Serum 25(OH)D values weremeasured with an RIA kit (DiaSorin, Stillwater OK), whileBMI was calculated from measured height and weight.BMI was negatively related to serum 25(OH)D in all threegroups, but the relationship was noticeably stronger inwhites than in blacks or Mexican Americans. Adjustingfor confounders reduced, but did not remove, thesedifferences in relationship strength. In conclusion, theserum 25(OH)D-BMI relationship in young adult womenvaries by race and ethnicity, being stronger in whites thanin blacks or Mexican Americans. The basis for this variationrequires further investigation.