ABSTRACT
Objective To investigate the effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness,blood viscosity and prognosis in the patients with high-risk chronic obstructive pulmonary disease (COPD).Methods A total of 240 patients with high-risk COPD and risk factors of cardiovascular disease were divided into the statin group(A),Yiqi H uoxue H uatan group(B),combined group(C) and control group(D),60 cases in each group.All groups were treated with routine therapy.On this basis,the group A was combined with low-dose atorvastatin,the group B was combined with Yiqi Huoxue Huatan Formula.On the basis of the group A,the group C was combined with Yiqi Huoxue Huatan Formula.All groups were treated for 6 months.The changes of TCM syndrome scores,arterial stiffness index and blood rheological indexes in 4 groups were observed and compared between before and after treatment.The situation of adverse reactions occurrence and prognosis were recorded.Results After 6 months of treatment,the TCM syndrome scores and carotid artery-femoral artery pulse wave velocity (PWV)in 4 groups were significantly decreased compared with those before treatment,which in the group C,A,B and D was gradually increased (P＜ 0.05).After 6 months of treatment,there was no significant change of whole blood viscosity and hematocrit in the group D (P＞ 0.05),which in the other 3 groups were significantly decreased compared with those before treatment,moreover the group C was significantlylower than the group A and B (P＜0.05),while there was no statistically significant difference between the group A and B (P＞0.05).The incidence rate of adverse reactions had no statistically significant difference among the four groups (P＞ 0.05).The BODE index showed gradual increase ih the group C,A,B and D (P＜0.05).Conclusion Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin has an positive effect in regulating the blood rheological state and promoting the prognostic recovery in the patients with high-risk COPD and risk factors of cardiovascular disease.
ABSTRACT
Objective To investigate the effect of Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin on arterial stiffness,blood viscosity and prognosis in the patients with high-risk chronic obstructive pulmonary disease (COPD).Methods A total of 240 patients with high-risk COPD and risk factors of cardiovascular disease were divided into the statin group(A),Yiqi H uoxue H uatan group(B),combined group(C) and control group(D),60 cases in each group.All groups were treated with routine therapy.On this basis,the group A was combined with low-dose atorvastatin,the group B was combined with Yiqi Huoxue Huatan Formula.On the basis of the group A,the group C was combined with Yiqi Huoxue Huatan Formula.All groups were treated for 6 months.The changes of TCM syndrome scores,arterial stiffness index and blood rheological indexes in 4 groups were observed and compared between before and after treatment.The situation of adverse reactions occurrence and prognosis were recorded.Results After 6 months of treatment,the TCM syndrome scores and carotid artery-femoral artery pulse wave velocity (PWV)in 4 groups were significantly decreased compared with those before treatment,which in the group C,A,B and D was gradually increased (P＜ 0.05).After 6 months of treatment,there was no significant change of whole blood viscosity and hematocrit in the group D (P＞ 0.05),which in the other 3 groups were significantly decreased compared with those before treatment,moreover the group C was significantlylower than the group A and B (P＜0.05),while there was no statistically significant difference between the group A and B (P＞0.05).The incidence rate of adverse reactions had no statistically significant difference among the four groups (P＞ 0.05).The BODE index showed gradual increase ih the group C,A,B and D (P＜0.05).Conclusion Yiqi Huoxue Huatan Formula combined with low-dose atorvastatin has an positive effect in regulating the blood rheological state and promoting the prognostic recovery in the patients with high-risk COPD and risk factors of cardiovascular disease.
ABSTRACT
Objective To investigate the effect of Yiqi Huoxue Huatan Decoction(YHHD) on gene expression of vascular endothelial growth factor(VEGF), intercellular adhesion molecule 1(ICAM-1) in the colonic mucosa of ulcerative colitis rats. Methods Sixty rats were divided into six groups, namely normal control group, model control group, low-, middle- and high-dose Y HHD group(gastric gavage of YHHD in the dosage of 13, 26, 52 g·kg-1·d-1 respectively) , and Mesalazine(0.5 g·kg-1·d-1 ) group. T he rat model of ulcerative colitis was established by enema with 2, 4, 6-trinitrobenzene sulfonic acid(TNBS)mixture(2.5%TNBS and 50% ethanol). The changes in rat body weight were monitored. After treatment, pathological features of the colonic mucosa were observed under light microscope, and VEGF and ICAM-1 gene expression levels in the colonic mucosa were measured by reverse t ranscripti on polymerase chai n reaction(RT-PCR). Results Body weight was lighter, and relative gene expression levels of VEGF and ICAM-1 in the model group were significantly higher than those in the normal control group, and pathological features of the colonic mucosa was obvious, the differences being significant between the two groups(P<0.01). Compared with the model group, body weight was increased , pathological features of the colonic mucosa were relieved, and relative gene expression levels of VEGF and ICAM-1 were significantly decreased in YHHD groups(P<0.01), and high-dose YHHD showed the strongest effect. Conclusion YHHD can down-regulate the gene expression of VEGF and ICAM-1, which may be one of its therapeutic mechanisms for ulcerative colitis.