ABSTRACT
【Objective】 To reduce the occurrence of adverse reactions to blood donation during platelet collection in female blood donors with low body weight and high platelet count, so as to improve the comfortableness during platelet collection and increase the proportion of repeated blood donors. 【Methods】 The control group and observation group were compared to explore the causes that may cause adverse reactions in the blood collection cycle using blood collection process program software in MCS+, and the incidence of blood donation reaction was compared and observed by increasing the times of oral administrations of calcium gluconate by 10%, increasing the number of collection cycles and reducing the peak plasma volume of the last cycle. 【Results】 After comparing the two groups, it was found that the incidence of adverse reactions in the observation group and the control group was 16.7%(3/18) and 81.2%(26/32), the proportion of repeated donors in the observation group and the control group was 77.7%(14/18) and 31.2%(10/32). 【Conclusion】 Female platelet donors with low body weight and high platelet count should be given more care during the collection process. It is suggested that giving more times of oral administrations of calcium gluconate by 10% and one more collection cycle to reduce the collection peak in each cycle, as well as the supplement of saline, which can effectively reduce the occurrence of adverse reactions to blood donation, thus improving blood donation satisfaction and increasing the proportion of repeated blood donors.
ABSTRACT
【Objective】 To investigate the high-risk groups and scenarios of adverse reactions to blood donation(ARBD) through statistical analysis of the incidence and distribution of ARBD in Beijing from 2017 to 2020, and discuss the preventive measures, so as to retain more regular blood donors with better service and blood donation experience. 【Methods】 The data of 1 047 036 voluntary blood donors during 2017 to 2020 were reviewed. The incidence of blood donation reactions was counted, and factors as gender, blood collection sites, blood group and number of blood donations were collected, the influencing factors of ARBD were analyzed to put forward targeted solutions. 【Results】 Among 1 047 036 blood donations in Beijing from 2017 to 2020, 2 163 (0.21%) developed ARBD. The incidence of ARBD in women was twice that in men, and was highest in age group 18 to 25 years old (47.8%, 1 034/2 163). In terms of blood donation sites, the incidence of ARBD was close under different blood donation environments, but ARBD occurred in mobile donation sites accounted for 65.51% (1 417/2 163). The incidence of ARBD in different blood types was basically the same, that of repeated blood donors was the lowest, and that of first-time blood donors accounted for 66.07% (1 429/2 163). The incidence of ARBD occurred within 30 minutes after blood donation was 43.64% (944/2 163), and it was dominated by systemic manifestations (Class B) (73.05%, 1 580 / 2 163). 【Conclusion】 Gender, age, blood donation sites, number of blood donations, occurrence time and ARBD categories were the influencing factors of ARBD. It is suggested to pay more attention to women, young and first-time blood donors, improve blood donation environment, and stay for 30 minutes after blood donation.
ABSTRACT
【Objective】 To investigate the establishment of multi-center haemovigilance (HV) and the monitoring of adverse reactions to blood donation (ARBD), in order to provide basis for the management of blood donors. 【Methods】 The operation of HV was investigated by questionnaire. The total number of blood donations (including plateletpheresis) and ARBD cases occurred in each blood center from 2014 to 2018 were analyzed. 【Results】 Among the 24 blood centers in this survey, only nine got HV operated. The incidence of ARBD of 19 blood centers that fulfilled the questionnaire was in the range of (0.003~1.151) %. The change trend of number and incidence of ARBD cases were indeterminate. 【Conclusion】 Most blood centers did not got HV established. The incidence of ARBD varied greatly and was indeterminate. The application of HV should be further improved to strengthen ARBD management.
ABSTRACT
【Objective】 To systematically evaluate the characteristics of adverse reactions to blood donation(ARBD) among whole blood donors in China, so as to provide scientific basis for the prevention and control of adverse reactions related to blood donation. 【Methods】 PubMed, EMbase, CNKI, VIP and WanFang Data were retrieved to collect research literature concerning ARBD among whole blood donors in mainland China with observation time≥6 months. The retrieval time was set from the time of database establishment to June 2020. The literature was supplemented by reference tracing and manual retrieval. Two reviewers independently screened the literature, extracted the data, and evaluated the methodological quality of the included studies according to the inclusion and exclusion criteria. Then Review Manager 5.3 software was used for Meta analysis. 【Results】 A total of 36 literature were included, involving 3 769 415 blood donors and 38 403 cases of ARBD. Meta-analysis results showed that the overall incidence of ARBD among whole blood donors was 1.36% [95%CI (1.19, 1.54)], and 1.52% [(95%CI (1.26, 1.78)] in the eastern, 1.26% [(95%CI (0.87, 1.70)] in the central, and 0.76% [(95%CI (0.74, 1.21)] in the western China when stratifying by geographic distribution, with statistically significant differences (P<0.01). The incidence of ARBD in male and female whole blood donors was 1.19% [(95%CI (0.99, 1.39)] and 1.26% [(95%CI (1.05, 1.48)), respectively, which was more commonly reported by women than by men (P<0.01). The incidence of ARBD was 2.17% [(95%CI (1.82, 2.52)], 0.98% [(95%CI (0.82, 1.14)] and 0.76% [(95%CI (0.61, 0.91)] in the age groups of 18~24, 25~40, and 41~55, respectively, and the incidence in donors aged 18~24 years was significantly higher than that in other two age ranges (P<0.01). The incidence of ARBD in first-time and repeat blood donors was 1.57% [(95%CI (1.35, 1.79)] and 0.63% [(95%CI (0.56, 0.70)), respectively(P<0.01). The incidence of ARBD with blood donation <400 mL and 400 mL was 1.10% [(95%CI (0.90, 1.30), P<0.001] and 0.87% [(95%CI (0.71, 1.03), P<0.001], respectively(P<0.01). 【Conclusion】 In order to improve the effectiveness of ARBD monitoring, it is necessary to unify the standards for ARBD, strengthen the knowledge training of ARBD, and accelerate the information construction to explore the national ARBD monitoring mode.
ABSTRACT
【Objective】 To investigate the management of adverse reactions to blood donation(ARBD) in blood services, so as to promote the surveillance of ARBD and improve the quality of blood donation service in Chongqing. 【Methods】 A questionnaire, involving the staff and facilities in blood donation sites as well as the prevention and treatment, the record and report, the following up and data related to ARBD was developed by Chongqing Society of Blood Transfusion in February 2019, and was issued to 18 blood services(1 blood center and its sub-center, 6 central blood stations and 11 hospital blood banks) in the Chongqing via email. The questionnaire was filled in and submitted before March 31 by management personnel participating in the investigation, and the data was collected, collated, revised and analyzed by Excel 2011. 【Results】 A total 19 questionnaires were collected, with the valid rate at 100%(19/19). 78.95%(15/19) of the blood services met the requirements of medical personnel allocation(>6 medical staff) when the number of daily blood collection was more than 60, and 100%(19/19)met the requirements of medical personnel allocation(2 to 6 medical staff) when the number of daily blood collection was less than 60. 89.47%(17/19) of the blood services were equipped with epinephrine hydrochloride, and 84.21%(16/19) with dexamethasone(an anti-allergic drug). There were significant differences in the allocation of other types of drugs. 100.00%(19/19) of the blood services formulated prevention and treatment measures concerning ARBD. In 2019, the incidence of ARBD in Chongqing was reported to be 0.54%(1 958 / 359 871), with the highestas [1.35%(223/16 543)] in subcenters and the lowest [0.32%(179/56 299)] in central blood centers (P<0.05). There was statistical significances in the incidences of ARBD reported by different blood stations(P<0.05). 【Conclusion】 The monitoring and management of ARBD among blood services in Chongqing should be further standardized in terms of staffing allocation, emergency drugs allocation and reporting, so as to gradually realize regional homogenization and ensure blood safety.