ABSTRACT
Objective: It was investigated to enlighten the phytochemical screening and antihyperlipidemic activity of seeds of Canavalia ensiformis (L.) in High fat diet Streptozotocin-induced diabetic rats. Methods: The ethanolic seed extract of Canavalia ensiformis (EECE) at a dose of 400 mg/kg and 200 mg/kg was administered to diabetic rats. Simvastatin (4 mg/kg) is used as a standard drug. Results: The statistics were assessed by using one way ANOVA followed by Dunnet’s multiple comparison tests. To unfold the mechanism we studied all the biochemical parameters like Total cholesterol (TC), Triglycerides (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL) and histopathological examination of Liver tissue section. The ethanolic extracts of seeds of Canavalia ensiformis showed significant reduce of the level of cholesterol, triglycerides, LDL, VLDL and a significant increase in the serum level of HDL at 400 mg/kg rather than 200 mg/kg. Conclusion: Further the characterization and isolation of the constituents could be done to know the exact mechanism of hyperlipidemic activity. Statistical analysis of this screening method conforms that the proposed method is appropriate and it can be useful, gives the basic idea to the researcher who is working in an area like Antihyperlipidemic activity.
ABSTRACT
Acute myocardial infarction is one of the important reasons of death and unhealthiness in the world. The present study was undertaken to investigate the changes in serum lipids and lipoproteins in patients with acute myocardial infarction. The levels of lipid profile were significantly changed in the acute myocardial infarction patients. Acute myocardial infarction patients had significantly higher levels of total cholesterol, LDL-cholesterol, TG, Lipoprotein and lower level of HDL-cholesterol, as compared to the control subjects. We found a significant association of lipid profiles with acute myocardial infarction. Reduced serum HDL-cholesterol and increased Serum LDL, Serum TG, Lipoprotein (a), in our study subjects may be the effective reasonable lipid disorders in AMI patients.
ABSTRACT
This study was designed to investigate the effects of pyroligneous liquor on lipid metaboilsm in serum of SPF/VAF Cri/ Bgi CD rats. Male CD rats were fed basic diet prepared in our Lab., and PL-0 ( control) , PL-1, PL-25, PL-50, PL-75 groups were prepared with pyroligneous liquor ( 35% of Choa Co. Ltd.) of 0%, 1%, 25%, 50% and 75% in purified water per day for 8 weeks. Body weights and food intakes almost did not change in these five groups, and triglyceride ( TG) levels were significantly decreased ( 20.5% and 19.5%, respectively) in these PL-25 and PL-50 groups compared with control group. Total and LDL-cholesterol levels were markedly decreased ( 20.7%, 16.3% and 20.3 %, 116.9%, respecti-vely) in these PL-25 and PL-50% groups, but HDL-cholesterol levels were significantly increased about 36.4% and 25.5% in serum of PL-25 and PL-50 groups compared with control group. Atherogenic indices were also remarkedly decreased ( 63.0%, and 50%, respectively) in these PL-25 and PL-50 groups compared with control group. These results suggest that long term administration orally of pyroligneous liquor in 25 to 50% may inhibit chronic degenerative disease through improving of lipid metabolism of lower TG & LDL-cholesterol and higher HDL-cholesterol, and lower AJ.