ABSTRACT
With the understanding of the development and pro-gress of the cancer,the research of targeted cancer drug devel-opment reaches into a new era.p53 is an important tumor sup-pressor gene,the protein coded by p53 plays a critical role in tumor suppression mainly by inducing cell cycle regulation, DNA repair and apoptosis.Nowadays,p53 becomes a relatively attractive target for anti-cancer drug development and there are some drugs targeting p53,moreover,APR-246 which targets mutant p53 is in Phase II clinical trial.In addition,it facilitates drugs discovery programmes in the challenging area of protein-protein interactions and mutant protein conformational change. The review discusses the research progress of drugs which target p53 and elucidates the characteristics and mechanisms of these compounds.
ABSTRACT
Non-surgical method plays a very important role in the treatment of hepatocellular carcinoma(HCC). The related evidence-based medical research findings such as the therapeutic effect differences in different technical methods, materials of ablation therapy and interventional therapy, and in the survival benefits of differential anti-tumor drugs etc, have attracted more and more attention.