The influence of psychological readiness of athletes when returning to sport after injury

Background: Injuries are a common occurrence in sports participation; however, they have the potential to be accompanied by negative thoughts and feelings, which may play a part in the athletes' state of mind when they return to their sport. Assessing the degree to which this occurs provides an opportunity to evaluate and address athletes' state of mind before their return to play. Objectives: To determine if athletes are psychologically ready to return to play after an injury and if there are differences in fear avoidance behaviour between those who were and were not ready to return. Methods: Eighty-eight athletes participated in this descriptive survey. Athletes' confidence to return to play was measured by the Injury-Psychological Readiness to Return to Play (I-PRRS) questionnaire and their fear avoidance was measured by the Athlete Fear Avoidance Questionnaire (AFAQ). Results: Fifty injured athletes with a mean age of 23.3±4.0 years old responded to the I-PRRS and the AFAQ questionnaires. The average I-PRRS score was 46.5±9.1 AU. The evidence suggests that 60% of the athletes were not ready to return to sport (41.0±7.5 AU), whereas 40% were ready to return (54.8±3.1 AU). The difference in scores was not significant. The relationship between the AFAQ scores and the I-PRRS score for the 'ready' and 'not ready' groups was not significant (p=0.066). The mean AFAQ score (26.1±8.6 AU) for the 'not ready' group is marginally greater than the mean AFAQ score (21.6±7.5 AU) for the 'ready' group. There was a negative correlation between psychological readiness to return to sport and athletic fear avoidance (r =-0.508, p<0.001). Conclusion: There needs to be a greater utilisation of psychological assessment tools like the Injury-Psychological Readiness to Return to Play (I-PRRS) questionnaire, which can assist the athlete's support team, who can help identify athletes who are apprehensive about returning to sport after injury.

Experiential Avoidance and Hyperreflexivity as Variables Associated with Depression: A Process-Based Approach

La depresión es un problema importante de salud pública que afecta a una proporción significativa de adultos jóvenes, como los estudiantes universitarios. Para su estudio se ha propuesto un enfoque basado en procesos, que busca identificar variables psicológicas transdiagnósticas que puedan ser objeto de cambio en las intervenciones psicoterapéuticas. El propósito de este trabajo fue analizar la interrelación entre un conjunto de variables de proceso (fusión cognitiva, rumia y evitación experiencial), así como examinar la relación entre cada una de estas variables y la depresión en 368 estudiantes universitarios de entre 18 y 29 años (M = 21.35, DE = 2.36, 77.7 % mujeres). Se halló que la fusión cognitiva y la rumia conformaban una variable global denominada hiperreflexividad, mientras que la evitación experiencial constituía un constructo diferente. Al analizar un modelo de ecuaciones estructurales, se encontró que solo la hiperreflexividad predecía significativamente la depresión. Se discuten estos resultados y sus posibles implicaciones para la práctica clínica. Se recomienda seguir estudiando la hiperreflexividad como una variable supraordinada de relevancia para la psicopatologia.

Depression is a major public health problem that affects a significant proportion of young adults, such as college students. A process-based approach has been proposed for its study, which seeks to identify transdiagnostic psychological variables that can be the target of change in psychotherapeutic interventions. The purpose of this paper was to analyze the interrelation between a set of process variables (cognitive fusion, rumination, and experiential avoidance), as well as to examine the relationship between each of these variables and depression in 368 college students aged 18-29 years (M = 21.35, SD = 2.36, 77.7% female). Cognitive fusion and rumination were found to comprise an overarching variable termed hyperreflexivity, while experiential avoidance constituted a different construct. By analyzing a structural equation model, it was found that only hyperreflexivity predicted depression significantly. These findings and their possible implications for clinical practice are discussed. Further study of hyperreflexivity as a superordinate variable of relevance to psychopathology is recommended.

Effect of amitriptyline on learning and memory consolidation in the male Wistar rats with an experimental model of pentylenetetrazole-induced seizure

Abstract Amitriptyline (AMT) was developed for the treatment of chronic and neuropathic pain. There is also evidence it may be useful in the treatment of neurodegenerative disorders. In this regard, the effect of on the experimental model of seizures and memory impairment caused by seizures in rats is investigated in the present study. Seizures in Wistar rats (200-250 g) were induced by pentylenetetrazole (PTZ, 60 mg/kg, intraperitoneally (i.p.)). The anticonvulsant effect of AMT (10 and 20 mg/kg, i.p.) was evaluated in the seizure model. The effect on memory was assessed using passive avoidance (PA) learning and memory test. After behavioral tests, the animals underwent deep anesthesia and were put down painlessly. Animal serum was isolated for oxidant/antioxidant assays (malondialdehyde (MDA), and glutathione peroxidase (GPx)). Intraperitoneal injection of AMT decreased the mean number of myoclonic jerks and generalized tonic-clonic seizure (GTCS) duration and increased the mean latency of myoclonic jerk and GTCS compared to the PTZ group. Moreover, in the PA test, AMT caused a significant increase in retention latency (RL) and total time spent in the light compartment (TLC) compared to the PTZ group. Biochemical tests showed that AMT was able to significantly increase GPx serum levels and significantly reduce MDA serum levels compared to the PTZ group. Overall, this study suggests the potential neuroprotective effects of the AMT drug in a model of memory impairment caused by seizures via the mechanism of inhibition of the oxidative stress pathway.

Grupos de riesgo por COVID-19 y sus estrategias para enfrentar la sobrecarga informativa en el primer año de la pandemia en Chile / COVID-19 risk groups and their strategies for navigating information overload during the first year of the pandemic in Chile

RESUMEN Este artículo se enmarca en el proyecto EIS-COVID sobre acceso y uso de información en el contexto de la pandemia de COVID-19 en Chile. Su objetivo fue conocer cómo se constituyó el entorno informativo de las personas en la primera etapa de la pandemia. El artículo muestra los resultados de un estudio cualitativo enfocado en personas pertenecientes a grupos de riesgo por COVID-19: personas mayores de 18 y menores de 65 años con enfermedades crónicas (hipertensión y diabetes) y personas de 65 años y más. Se realizaron 90 entrevistas semiestructuradas en las regiones Metropolitana y de Valparaíso entre septiembre de 2020 y enero de 2021. Se identifica la problemática de la sobrecarga informativa para estos grupos y las estrategias que utilizaron para enfrentarla: a) la evitación de información, b) la corroboración de contenidos y búsqueda activa de fuentes confiables, o c) el uso diferenciado de medios.

ABSTRACT As a part of the EIS-COVID project on the access and use of information during the COVID-19 pandemic in Chile, the objective of this paper was to ascertain how people's informational environment was constructed during the first stage of the pandemic. It discusses the results of a qualitative study of people belonging to risk groups for COVID-19: people over 18 and under 65 with chronic diseases (hypertension and diabetes) and people 65 and over. Ninety semi-structured interviews were conducted in the Metropolitan and Valparaíso regions between September 2020 and January 2021. The results reveal the problematic nature of the information overload encountered by these groups and the strategies they used to navigate it: a) information avoidance; b) content corroboration and active search for reliable sources; and c) differentiated media use.

N-methyl-D-aspartic acid receptor/MAPK/cAMP-response element binding protein pathway mediating pain-related aversion in anterior cingulate cortex / 解剖学报

Objective To explore the mechanism of N-methyl-D-aspartic acid ( NMDA) receptor/MAPK/cAMPresponse element binding protein ( CREB) pathway involved in pain-related aversion mediated by anterior cingulate cortex. Methods A total of 42 healtlry SD rats were randomly divided into control group (Ctrl) , normal saline(NS) injection group (NS) , complete freund adjuvant (CFA) model group ( CFA ) , injected CFA into the soles of the foot and injected NS into rostral part of anterior cingulate cortex (rACC)group (CFA+NS) , injected NS into the soles of the foot and injected NS into rACC group (NS+NS) , injected CFA into the soles of the foot and injected NMDA receptor antagonist ( APV ) into rACC group (CFA+APV) , injected NS into the soles of the foot and injected APV into rACC group ( NS + APV ) with 6 rats in each group. Rats avoidance score was analysised and rat thermal foot contraction latency ( PWL) ws alserved, the expression of NMDA receptor in rACC region was detected by immunohistochemical staining, the expression of NMDA receptor, phosphorylated ERK( p-ERK) and phosphorylated CREB ( p - CREB ) in rACC region was detected by immunofluorescent staining, the number of Nissl bodies in rACC region was observed by Nissl staining, and the expression of NMDA receptor, MAPK, CREB, ERK, p-ERK, p-CREB, synaptosomal-associated protein 25 interaction protein 30 (SIP30) protein in rACCregion was detected by Western blotting, and Real-time PCR was used to detect the mRNA expression of NMDA receptor, MAPK, CREB and ERK in the rACC region. Results Compared with the Ctrl group, the avoidance score and PWL decreased significantly and the expression of NMDA receptor, MAPK and CREB increased significantly in the CFA group (P<0. 05). Compared with the CFA+NS group, the number of Nissl bodies in CFA+APV and NS+APV groups increased significantly, while the expression of NMDA receptor, MAPK, CREB, p-ERK and p-CREB decreased significantly in NS+NS and NS+APV groups (P<0. 05). Conclusion NMDA receptor-MAPK-CREB signal pathway in rACC is involved in painrelated aversion, and inhibition of NMDA can reduce pain-related negative aversion.

Avoidance of Asari Radix et Rhizoma Toxicity in Classical Prescriptions Based on Ancient and Modern Literature / 中国实验方剂学杂志

ObjectiveThrough the review of the literature about Asari Radix et Rhizoma， we extracted the key information affecting the toxicity of Asari Radix et Rhizoma， aiming to provide a basis for the rational application of Asari Radix et Rhizoma in the classical prescriptions. MethodThe bibliometric method was employed to analyze the ancient and modern literature and thus reveal the relationship of Asari Radix et Rhizoma toxicity with the medicinal plants， medicinal part， processing method， dosage form， prescription compatibility， medication method， and patients' physical factors. ResultThe dosage of Asari Radix et Rhizoma in Danggui Sinitang and Houpo Mahuangtang was 9 g and 6 g， respectively， and the decocting time should be longer than 120 min. The single dosage of Asari Radix et Rhizoma in Xinyisan， Sanbitang， Daqinjiao Tang， and Qingshang Juantongtang were 0.8， 1.2， 0.9， and 1.1 g， respectively. The rhizome of Asarum heterotropoides var. mandshuricum or A. sieboldii var. seou1ense should be selected for Danggui Sinitang， Houpo Mahuangtang， and Qingshang Juantongtang， while that of A. siebodii var. seou1ense should be selected for Xinyisan. In terms of processing， Asari Radix et Rhizoma can be processed with wine when being used in Danggui Sinitang， Houpo Mahuangtang， Sanbitang， and Daqinjiaotang， and it can be stir-fried when being used in Xinyisan and Qingshang Juantongtang. In addition， the toxicity of Asari Radix et Rhizoma is associated with the compatibility of drugs and the physical conditions of patients. ConclusionBy reviewing the literature on Asari Radix et Rhizoma toxicity， we obtained the key information affecting the toxicity of Asari Radix et Rhizoma and explored the effective ways to avoid the toxicity. This study provides a sufficient basis for the rational development and safe application of the classical prescriptions containing Asari Radix et Rhizoma.

8-Hydroxyquinolylnitrones as multifunctional ligands for the therapy of neurodegenerative diseases

We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase-hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases. We identified QN 19, a simple, low molecular weight nitrone, that is readily synthesized from commercially available 8-hydroxyquinoline-2-carbaldehyde. Quinolylnitrone 19 has no typical pharmacophoric element to suggest ChE or MAO inhibition, yet unexpectedly showed potent inhibition of hBChE (IC50 = 1.06 ± 0.31 nmol/L) and hMAO-B (IC50 = 4.46 ± 0.18 μmol/L). The crystal structures of 19 with hBChE and hMAO-B provided the structural basis for potent binding, which was further studied by enzyme kinetics. Compound 19 acted as a free radical scavenger and biometal chelator, crossed the blood-brain barrier, was not cytotoxic, and showed neuroprotective properties in a 6-hydroxydopamine cell model of Parkinson's disease. In addition, in vivo studies showed the anti-amnesic effect of 19 in the scopolamine-induced mouse model of AD without adverse effects on motoric function and coordination. Importantly, chronic treatment of double transgenic APPswe-PS1δE9 mice with 19 reduced amyloid plaque load in the hippocampus and cortex of female mice, underscoring the disease-modifying effect of QN 19.

Phase II trial of hippocampal avoidance whole-brain irradiation with simultaneous integrated boost for treatment of brain metastases of lung cancer / 中华放射肿瘤学杂志

Objective:To evaluate the efficacy and safety of hippocampal avoidance whole-brain irradiation with simultaneous integrated boost in the treatment of brain metastases of lung cancer.Methods:Forty lung cancer patients with brain metastases who received whole-brain radiotherapy with simultaneous integrated boost and hippocampal avoidance in Cancer Hospital, Chinese Academy of Medical Sciences from 2014 to 2020 were enrolled in this study. Brain MRI, survival follow-up and evaluation of side effects were performed before radiotherapy and at 1, 3, 6 and 12 months after radiotherapy, respectively. Overall survival (OS), progression-free survival (PFS) and changes in cognitive function were analyzed. Continuous data were described as Mean ± SD. Categorical data were described by frequency and composition ratio or percentage. Survival analysis was conducted by Kaplan-Meier method. Influencing factors of survival were identified by univariate and multivariate Cox's regression analyses.Results:A total of 40 patients were enrolled in the study. The median follow-up time was 14.2 months and the median OS, PFS and intracranial PFS of all patients were 14.8 months, 6.7 months and 14.8 months, respectively. Multivariate analysis showed that male gender and newly diagnosed stage Ⅳ disease were associated with worse OS and PFS, respectively. The Hopkins verbal learning test-revised (HVLT-R) scores at baseline and 1, 3 and 6 months after radiotherapy were 21.94±2.99, 20.88±3.12, 20.03±3.14, and 19.78±2.98, respectively. The HVLT-R score at 6 months after radiotherapy was decreased by approximately 9.8% compared with the baseline. No grade 3 or above toxic and side effect occurred in the entire cohort.Conclusion:Hippocampal avoidance whole-brain irradiation with simultaneous integrated boost is a safe and effective treatment for brain metastases of lung cancer, which is expected to reduce the impact of radiotherapy on cognitive function.

Chain mediating effect of experience avoidance and emotional eating between intolerable uncertainty and life satisfaction in college students / 中华行为医学与脑科学杂志

Objective:To explore the mediating effect of experiential avoidance and emotional eating between intolerable uncertainty and life satisfaction of college students.Methods:From October to December 2021, a total of 890 college students in the Beijing-Tianjin-Hebei region were tested by the intolerable uncertainty scale (simplified version), the acceptance action scale second edition, the Dutch eating behavior questionnaire and the life satisfaction scale. All data processing and analysis were preformed by SPSS 22.0 software, and the mediating effect was tested by Pearson correlation analysis and Bootstrap analysis.Results:The intolerable uncertainty score was (26.43±7.64), the experiential avoidance score was (22.63±9.67), the emotional eating score was (26.43 ±11.83), and the life satisfaction score was (16.74±6.03). Intolerable uncertainty was significantly and negatively correlated with life satisfaction( r=-0.76, P<0.01), and was significantly and positively correlated with experience avoidance and emotional eating( r=0.66, 0.78, both P<0.01). Experience avoidance was significantly and positively correlated with emotional eating( r=0.70, P<0.01), and was significantly and negatively correlated with life satisfaction( r=-0.62, P<0.01). Emotional eating was significantly and negatively correlated with life satisfaction( r=-0.68, P<0.01). Intolerable uncertainty affects life satisfaction through four paths.The direct effect value of intolerable uncertainty on life satisfaction was -0.53, accounting for 70.23% of the total effect. The separate mediating effect value of experience avoidance was -0.11, accounting for 50.00% of the total indirect effect.The separate mediating effect value of emotional eating was -0.08, accounting for 36.36% of the total indirect effect, and the chain mediating effect value of experience avoidance and emotional eating was -0.03, accounting for 13.64% of the total indirect effect. Conclusion:Intolerable uncertainty can directly affect life satisfaction of college students and indirectly through experiencing avoidance and emotional eating.

Childhood trauma and non-suicidal self-injury in college students: chain mediating effects of rejection sensitivity and experiential avoidance / 中华行为医学与脑科学杂志

Objective:To explore the effect of childhood trauma on non-suicidal self-injury and the chain mediating effect of rejection sensitivity and experiential avoidance.Methods:From June 2021 to April 2022, totally 1 130 college students were investigated with childhood trauma questionnaire-short form(CTQ-SF), the tendency to expect rejection scale, acceptance and action questionnaire-2nd edition(AAQ-Ⅱ) and Ottwa self-injury inventory(OSI). SPSS 25.0 and Mplus 8.0 software were used for descriptive analysis, Spearman correlation analysis, structural equation model construction and Bootstrap mediation effect test.Results:Correlation analysis showed that childhood trauma (34.64±8.25), rejection sensitivity (58.02±9.54), experiential avoidance (23.90±7.96) and non-suicidal self-injury (0(0, 1)) were all significantly positively correlated with each other( r=0.163-0.532, all P<0.01). Structural equation model showed that empirical avoidance played a partial mediating effect between childhood trauma and non-suicidal self-injury in college students, with an effect size of 0.045(95% CI=0.013-0.084). Rejection sensitivity and experiential avoidance played a chain mediating effect between childhood trauma and non-suicidal self-injury in college students, with an effect size of 0.017(95% CI=0.005-0.035). Conclusion:Childhood trauma can directly predict non-suicidal self-injury in college students, and it can also indirectly predict non-suicidal self-injury through the partial mediation effect of experiential avoidance and the chain mediation effect of rejection sensitivity and experiential avoidance.

Mediating role of psychological resilience between family intimacy and adaptability and experiential avoidance among undergraduate nursing students / 中国职业医学

Objective: To investigate the mediating role of psychological resilience in the relationship between family intimacy and adaptability and experiential avoidance among undergraduate nursing students (hereafter referred as nursing undergraduates). Methods: A total of 725 nursing undergraduates from six colleges in Guangdong Province were selected as the research subjects using convenience sampling method. The Acceptance Action Questionnaire-2nd Edition, Conner-Davidson Resilience Scale and Family Intimacy and Adaptability Scale were used to evaluate the experiential avoidance, psychological resilience, and family intimacy and adaptability, respectively. Results: The mean scores of experiential avoidance, psychological resilience and family intimacy and adaptability among nursing undergraduates were (23.4±7.7), (58.8±8.9) and (99.7±20.3), respectively. The results of the mediation analysis indicated that the total effect of family intimacy and adaptability on experiential avoidance was -0.16 (P<0.01), with a direct effect of -0.05 (P>0.05). Psychological resilience played a significant mediating role in the relationship between family intimacy and adaptability and experiential avoidance among nursing undergraduates (P<0.01). The standardized mediation effect was -0.11, accounting for 68.8% of the total effect. Conclusion: Resilience plays a mediating role between family intimacy and adaptability and experiential avoidance among nursing undergraduates.

Análisis del Modelo de Miedo-Evitación (Fear-avoidance model) del Dolor Crónico / Analysis of the Fear-avoidance model of Chronic Pain

Se han propuesto diversos modelos para entender la experiencia dolorosa, dentro de los que destaca el "fear-avoidance model" o modelo de miedo-evitación. Este ensayo presenta y discute los principales postulados de los artículos más relevantes para entender el desarrollo y evolución de este modelo. Esta evolución nos permite comprender nuestra propia evolución como kinesiólogos musculoesqueléticos, visualizando una concepción fenomenológica del dolor, comprendiendo su complejidad y multidimensionalidad.

Several models have been proposed to understand the painful experience, among which the "fear-avoidance model" stands out. This essay presents and discusses the main postulates of the most relevant articles to understand the development and evolution of this model. This evolution allows us to understand our own evolution as musculoskeletal physical therapists, visualizing a phenomenological conception of pain, understanding its complexity and multidimensionality.

The effect of sub-threshold autistic traits on social avoidance and distress in high school freshmen: the role of perspective taking and an intervention study / 中华行为医学与脑科学杂志

Objective:To explore the influence of sub-threshold autistic traits on social avoidance and distress of senior high school freshmen, as well as the mediating effect of perspective taking, and to investigate the intervention effect of perspective taking intervention project on improving the ability of perspective taking and reducing social avoidance and distress behavior of high sub-threshold autistic traits individuals.Methods:A total of 1 401 subjects were investigated with the autism-spectrum quotient (AQ), interpersonal reactivity index-C (IRI-C) and social avoidance and distress (SAD) from September 1st to September 30th, 2018. According to the screening criteria of 27% statistically, totally 378 subjects were selected according to the scores of autistic spectrum quotient scale from high to low as the high sub-threshold autistic traits group. The top 32 subjects with high scores of autistic spectrum quotient scale were selected and randomly divided into intervention group and control group with 16 subjects in each group. The modified viewpoint selection group counseling program was used to conduct intervention research on 16 subjects with high sub-threshold autistic traits. SPSS 26.0 was used for common method deviation test, descriptive analysis, correlation analysis and repeated measurement variance analysis, and SPSS 26.0 PROCESS plug-in was used for intermediary effect analysis.Results:(1) The scores of sub-threshold autistic traits, perspective taking, social avoidance and distress of freshmen in senior high school were (113.26±11.35), (12.34±3.95) and (10.84±6.42) respectively. (2) Sub-threshold autistic traits, perspective taking, social avoidance and distress were significantly correlated with each other( r=-0.11-0.52, all P<0.01). (3) Sub-threshold autistic traits had a significant direct effect on social avoidance and distress, with a direct effect value of 0.28, accounting for 96.55% of the total effect.The total indirect effect of perspective taking on social avoidance and distress was significant, with the total indirect effect value of 0.01, accounting for 3.45% of the total effect. (4) In the intervention group, the perspective taking score of the post-test (15.69±3.86) was significantly higher than that of the pre-test (10.56±4.18) ( P<0.01). In the control group, there was no significant difference in the scores of perspective taking before and after the test((10.63±3.69), (11.44±3.03)) ( P>0.05). (5) In the intervention group, the scores of social avoidance and distress in the post-test (6.38±5.01) were significantly lower than that in the pre-test (15.00±6.07) ( P<0.001). In the control group, the score of social avoidance and distress in the post-test (15.81±6.33) was lower than that in the pre-test (19.00 ±5.38) ( P<0.05), but the scores of social avoidance and distress in the intervention group decreased even more. Conclusion:Perspective taking plays an mediating role between sub-threshold autistic traits and social avoidance and distress. Group counseling based on perspective taking was helpful to improve the perspective taking ability of people with high sub-threshold autistic traits and reduce social avoidance and distress behaviors.

Assessment of the level of health anxiety among college students in a private higher educational institution during COVID-19

BACKGROUND@#Worldwide, people who were exposed to the virus reported heightened health anxiety compared to the individuals with the absence of exposure related to the COVID-19 during the pandemic. Young adults reported higher levels of health anxiety when compared to other groups. To a certain extent, health anxiety serves a protective role until it becomes perseverate and dysfunctional. The researchers aim to describe the level of anxiety of college students by utilizing the COVID-19 Anxiety Syndrome Scale to form a foundation for programs and policies that would address dysfunctional health anxiety@*METHODS@#The researchers used a quantitative, non-experimental, descriptive online survey research design to describe the level of COVID-19 health anxiety among college students in a private higher educational institution in Central Luzon, Philippines.@*RESULTS@#A total of 378 college students completed the survey. Analysis revealed that participants checked for symptoms of COVID-19 and were worried about possibly contracting COVID-19 for more than 7 days within two weeks (M=3.9; SD=1.5). It also revealed that the participants avoided situations that put them at risk for COVID-19 at a similar frequency (M=4.1; SD=0.4).@*CONCLUSION@#The study reveals the sampled college students manifested COVID-19 anxiety for more than 7 days in a 2-week timeframe. This means that the students spend a significant amount of their time, in a two-week timeframe, worrying, checking, and avoiding situations that may put them at risk for COVID-19. These anxiety-induced behaviors may hinder the accomplishment of their activities of daily living or productive pursuits.

Analysis and prospect of platelet compatible transfusion / 中国输血杂志

Platelet compatible transfusion can effectively solve the immune mediated platelet transfusion refractoriness (PTR), save platelet resources and improve blood safety. This paper comments and prospects the compatibility modes of HLA, HPA and CD36, HLA antibody titer, antigen immunogenicity and the development of platelet compatible transfusion. The pattern of HLA compatible platelets involves the matching in the alleles, antigens and epitopes levels, respectively, as well as avoidance donor specificity antibody (DSA) method. While setting the mean fluorescence intensity (MFI) threshold of avoidance DSA needs to be explored when using the DSA prediction method. Allele specific HLA antibodies can be found in the patients with PTR. Therefore, the patients and donors should be genotyped for HLA-A, -B loci at high-resolution level in order to avoid allele specific HLA antibodies. The immunogenicity of various antigens or epitopes at HLA-A and -B loci are different. Selecting donor platelets with low antigen expression or low immunogenicity may be a way of HLA compatible platelets. As the probability and type of HPA antibody production are different in the various populations, the approaching of compatibility HPA involves allele matching and avoidance DSA. As to CD36, the compatibility mode mainly refers to avoidance DSA, which means blood donors with CD36 antigen type Ⅰdeficiency are preferentially selected, and then those with CD36 antigen type Ⅱ deficiency. In the future, more attention should be paid to the scale up of database capacity and update of the information construction. The time waiting for compatible platelets transfusion in clinical could be significantly shortened if the requiring and matching are only conducted within the inventory and candidate platelets.

Relación entre el uso problemático de Facebook y la evitación experiencial en jóvenes colombianos / Relationship between the Problematic Use of Facebook and Experiential Avoidance in Young Colombians

Resumen Las tecnologias facilitan la comunicación y la interacción e influyen en los comportamientos y actitudes. Sin embargo, pueden causar impacto negativo cuando interneren en las actividades cotidianas y afectan la salud mental, física y social. El objetivo del estudio fue analizar la relación entre el uso problemático de Facebook, la evitación experiencial y los componentes de la teoría biopsicosocial. Estudio de tipo correlacional con diseno transversal no experimental. En total participaron 677 jóvenes colombianos, que diligenciaron de manera voluntaria los cuestionarios de datos sociodemográficos, la escala de Aceptación y Acción-II (AAQ-II) y la escala de Adicción a Facebook de Bergen (BFAS). Los resultados muestran que los hombres presentaron mayor uso problemático de la red social y puntuaron más alto en los componentes de abstinencia y conflicto. Se encontró una relación positiva significativa entre el uso problemático, la evitación experiencial y todos los componentes de la teoría biopsicosocial. En conclusión, la evitación experiencial aporta a la comprensión del uso problemático de Facebook desde el análisis funcional y la teoría Biopsicosocial que orienta en la identificación de la sintomatología adictiva; estos hallazgos permiten direccionar futuras intervenciones.

Abstract Technologies facilitate communication and interaction, and influence behavior and attitudes. However, they can have a negative impact when they interfere with everyday activities that affect mental, physical, and social health. The objective of the study was to analyze the relationship between the problematic use Facebook, experiential avoidance, and components of the biopsychosocial theory. This study was of a correlational type with a non-experimental cross-sectional design. A total of 677 young Colombians participated, who voluntarily filled out the socio-demographic data questionnaires, the Acceptance and Action-II scale (AAQ-II), and the Bergen Facebook Addiction Scale (BFAS). The results show that men present more problematic use of the social network and scored higher on the abstinence and conflict components. A significant positive relationship was found between the problematic use, experiential avoidance, and all components of the biopsychosocial theory. In conclusion, the experiential avoidance contributes to the understanding of the problematic use Facebook from the functional analysis, and the biopsychosocial theory guides in the identification of the addictive symptomatology. These findings allow directing future interventions.

Association of insight, avoidance behavior, indecisiveness, and inflated responsibility with other clinical characteristics in children and adolescents with obsessive-compulsive disorder

Objectives: Although the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) includes ancillary symptom dimensions - insight, avoidance, degree of indecisiveness, inflated sense of responsibility, pervasive slowness/disturbance of inertia, and pathological doubting -, we know little about their clinical/scientific utility. We examined these ancillary dimensions in childhood obsessive-compulsive disorder (OCD), and tested their associations with clinical characteristics. Methods: Treatment-seeking children and adolescents (n=173) with a DSM-5 OCD diagnosis were recruited from six centers in India and evaluated with a semi-structured proforma for sociodemographic/clinical details, the Structured Clinical Interview for DSM-5, the CY-BOCS, the Children's Depression Rating Scale, and the Family Interview for Genetic Studies. Regression analysis was used to study the associations between ancillary dimensions (independent variables) and clinical variables (dependent variables). Results: 87.9% of the sample reported at least a mild-moderate severity of ancillary dimensions, which were highly intercorrelated. Multiple ancillary dimensions were correlated with illness severity on the CY-BOCS. On regression analysis, only insight and avoidance retained significance. There were few differential associations between OCD symptom and ancillary dimensions. Conclusion: Ancillary dimensions are more a feature of illness severity than differentially associated with individual symptom dimensions in childhood OCD. Insight and avoidance should be considered for inclusion in the assessment of illness severity in childhood OCD.

Validity evidence of the Brazilian version of the Young-Rygh Avoidance Inventory (YRAI) for the population of Rio Grande do Sul / Evidências de validade do inventário de evitação de Young-Rygh (YRAI) para a população do Rio Grande do Sul / Evidencia de validez de la versión Brasileña del inventario de evasión de Young-Rygh (YRAI) para la población de Rio Grande do Sul

This study examines the factorial structure, internal consistency, and convergent validity of the Young-Rygh Avoidance Inventory (YRAI). Five hundred and four adults from the state of Rio Grande do Sul participated, with an average age of 34.2 (SD = 12.9), who completed the Young Scheme Questionnaire (YSQ-S3), the Symptom Assessment Scale (SCL-90-R), and YRAI, through an online platform. An exploratory factor analysis was made to verify the distribution of items in common factors and convergent analysis with Spearman's non-parametric correlation to verify associations with psychopathological symptoms (SCL-90-R) and schemes (YSQ-S3). Three factors were found: Somatization and Search for Stimulation (α = 0,84), Cognitive Avoidance (α = 0,78), and Emotional Withdrawal (α = 0,62), with an omega value between 0,75 and 0,87. It was concluded that the Brazilian version of YRAI has appropriate psychometric properties, being valid for the concerned population. In addition, the interpretation of the construct validity was consistent with the theory.

Este estudo examina a estrutura fatorial, consistência interna e a validade convergente do Inventário de Evitação de Young-Rygh (YRAI). Participaram 504 adultos do estado do Rio Grande do Sul, com média de idade de 34,2 anos (DP = 12,9), que preencheram o Questionário de Esquemas de Young (YSQ-S3), a Escala de Avaliação dos Sintomas (SCL-90-R) e o YRAI, através de uma plataforma online. Realizaram-se a análise fatorial exploratória para verificar a distribuição dos itens em fatores comuns e a análise convergente com correlação não paramétrica de Spearman para verificar associações com sintomas psicopatológicos (SCL-90-R) e esquemas (YSQ-S3). Três fatores foram interpretados: Somatização e Busca por Estimulação (α = 0,84), Evitação Cognitiva (α = 0,78) e Retraimento Emocional (α = 0,62), com valor de ômega entre 0,75 e 0,87. Concluiu-se que a versão brasileira do YRAI possui propriedades psicométricas adequadas, sendo válida para a população em questão. Além disso, a interpretação da validade de constructo mostrou-se condizente com a teoria.

Este estudio examina la estructura factorial, consistencia interna y validez convergente del Inventario de Evitación de Young-Rygh (YRAI). Participaron 504 adultos de Rio Grande do Sul con edad media de 34,2 años (DE = 12,9), que completaron el Cuestionario de Esquemas de Young (YSQ-S3), Escala de Evaluación de Síntomas (SCL-90-R) y YRAI, por una plataforma online. El análisis factorial exploratorio se realizó para verificar la distribución de ítems en factores comunes. El análisis convergente con la correlación no paramétrica de Spearman para verificar las asociaciones con los síntomas (SCL-90-R) y esquemas psicopatológicos (YSQ-S3). Se encontraron tres factores: Somatización y Búsqueda de Estimulación (α = 0,84), Evitación Cognitiva (α = 0,78) y Retracción Emocional (α = 0,62). Com un valor omega entre 0,75 y 0,87. Se concluyó que la versión brasileña de YRAI tiene adecuadas propiedades psicométricas, siendo válida para esta población. Además, la validez de constructo fue consistente con la teoría.

Reduced Firing of Nucleus Accumbens Parvalbumin Interneurons Impairs Risk Avoidance in DISC1 Transgenic Mice / 神经科学通报·英文版

A strong animal survival instinct is to approach objects and situations that are of benefit and to avoid risk. In humans, a large proportion of mental disorders are accompanied by impairments in risk avoidance. One of the most important genes involved in mental disorders is disrupted-in-schizophrenia-1 (DISC1), and animal models in which this gene has some level of dysfunction show emotion-related impairments. However, it is not known whether DISC1 mouse models have an impairment in avoiding potential risks. In the present study, we used DISC1-N terminal truncation (DISC1-N

Research progress on hippocampal-avoidance whole brain radiotherapy / 中华放射肿瘤学杂志

With the advancement of imaging diagnosis and the development of modern radiotherapy, the survival of cancer patients has been prolonged and the incidence rate of brain metastases (BM) has been significantly increased. The quality of life of patients and potential radiotherapy-induced neurocognitive impairment have gradually captivated widespread attention. Whole brain radiotherapy (WBRT) is one of the common local therapies for BM patients. However, the application of WBRT is controversial because it may lead to neurocognitive impairment. The incidence of metastatic tumors in hippocampus and radiation-induced neurocognitive impairment can accelerate the implementation of hippocampal-avoidance WBRT (HA-WBRT). In this article, the feasibility of HA-WBRT was discussed and research progress in recent years was reviewed.