ABSTRACT
[Objective]We established a model of Lung-Yang Deficiency.[Methods]The factors such as smoking(exogenous evil effect on lung),swimming in ice water(cold body and exhaustion),swimming in common water(exhaustion),and taking the methimazole ice solution(immune suppression and inhale cold)were adopted to establish this Lung-Yang Deficiency model.SD rats were treated for 35 days,and their physical signs(diet changes,drinking and other typical symptoms)were observed.The hemorheological parameters of the treated animals were measured.[Results]At the later period,rats in the Lung-Yang Deficiency model showed several symptoms,such as wheeze,breathlessness,meanwhile,accompanied with dullness,drinking less water,chill.Compared with the normal group,the body weight and the back temperature of the treated rats were decreased significantly.The whole blood viscosity(WBV)and whole blood reduced viscosity(WBRV)on the low shear rate were significantly increased from the normal.So was found the rigidity finger,deformed finger and electrophoresis finger of RBC parameters.[Conclusion]This model is fit to the clinical investigation of Lung-Yang Deficiency,resulting in that our method for model establishment is feasible.
ABSTRACT
Objective To observe the effects of extracts of ginkgo leaves (EGL) on acute myocardial infarction, acute myocardial ischemia and blood hemorheology.Methods The effects of EGL on acute myocardial infarction were observed in dogs model induced by the ligation of anterior descending branch of left coronary artery; effects on acute myocardial ischemia were observed on rats model caused by intravenous injection of pituitrin and effects on blood hemorheology were observed in rabbits. Results EGL significantly reduced the myocardial infarction area, decreased the activities of lactate dehydrogenase and creatine phosphokinase in dogs, reduced the elevation of ST segment of electrocardiogram in rats with myocardial ischemia and decreased whole blood viscosity and plasma viscosity in rabbits. Conclusion EGL has protective effect against myocardial ischemic injury and can improve the parameters of blood hemorheology in rabbits. Its mechanism may be concerned with the reduction of the myocardial infarction area and infarction degree and the relief of acute myocardial ischemia.